MEMBRANE CURRENTS OF C6 CELLS IN PHARMACOLOGICAL INVESTIGATION
Samo za registrovane korisnike
2022
Autori
Nikolic, LjiljanaSavic, Danijela
Korać Jačić, Jelena
Petkovic, Branka
Stojadinovic, Gordana
Martac, Ljiljana
Bogdanović Pristov, Jelena
Konferencijski prilog (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Living cells exhibit multiple ion channel proteins and malfunction of these channels underlies
numerous diseases. Channelopathies include diseases of the nervous, cardiovascular, respiratory,
endocrine, urinary, and immune system. Currently, ion channels represent the second-largest target for existing drugs. Here, using the whole-cell patch-clamp technique, we explored the epinephrine effect on membrane ionic currents in glioma C6 cells. We demonstrate that epinephrine specifically evokes an increase of C6 cells outward ionic currents that is stable within 10 min, while it does not affect inward currents. Our results thus provide fine resolution and time frame for targeting ion channel activity that is crucial in pharmacological investigations.
Ključne reči:
Ion channels / whole-cell patch-clamp technique / glioma / epinephrine / pharmacologyIzvor:
PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings), 2022, 2, 589-592Izdavač:
- Society of Physical Chemists of Serbia
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200007 (Univerzitet u Beogradu, Institut za biološka istraživanja 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200053 (Univerzitet u Beogradu, Institut za multidisciplinarna istraživanja) (RS-MESTD-inst-2020-200053)
Napomena:
- kategorija M33
Institucija/grupa
Institut za multidisciplinarna istraživanjaTY - CONF AU - Nikolic, Ljiljana AU - Savic, Danijela AU - Korać Jačić, Jelena AU - Petkovic, Branka AU - Stojadinovic, Gordana AU - Martac, Ljiljana AU - Bogdanović Pristov, Jelena PY - 2022 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/2010 AB - Living cells exhibit multiple ion channel proteins and malfunction of these channels underlies numerous diseases. Channelopathies include diseases of the nervous, cardiovascular, respiratory, endocrine, urinary, and immune system. Currently, ion channels represent the second-largest target for existing drugs. Here, using the whole-cell patch-clamp technique, we explored the epinephrine effect on membrane ionic currents in glioma C6 cells. We demonstrate that epinephrine specifically evokes an increase of C6 cells outward ionic currents that is stable within 10 min, while it does not affect inward currents. Our results thus provide fine resolution and time frame for targeting ion channel activity that is crucial in pharmacological investigations. PB - Society of Physical Chemists of Serbia C3 - PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings) T1 - MEMBRANE CURRENTS OF C6 CELLS IN PHARMACOLOGICAL INVESTIGATION EP - 592 SP - 589 VL - 2 UR - https://hdl.handle.net/21.15107/rcub_rimsi_2010 ER -
@conference{ author = "Nikolic, Ljiljana and Savic, Danijela and Korać Jačić, Jelena and Petkovic, Branka and Stojadinovic, Gordana and Martac, Ljiljana and Bogdanović Pristov, Jelena", year = "2022", abstract = "Living cells exhibit multiple ion channel proteins and malfunction of these channels underlies numerous diseases. Channelopathies include diseases of the nervous, cardiovascular, respiratory, endocrine, urinary, and immune system. Currently, ion channels represent the second-largest target for existing drugs. Here, using the whole-cell patch-clamp technique, we explored the epinephrine effect on membrane ionic currents in glioma C6 cells. We demonstrate that epinephrine specifically evokes an increase of C6 cells outward ionic currents that is stable within 10 min, while it does not affect inward currents. Our results thus provide fine resolution and time frame for targeting ion channel activity that is crucial in pharmacological investigations.", publisher = "Society of Physical Chemists of Serbia", journal = "PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings)", title = "MEMBRANE CURRENTS OF C6 CELLS IN PHARMACOLOGICAL INVESTIGATION", pages = "592-589", volume = "2", url = "https://hdl.handle.net/21.15107/rcub_rimsi_2010" }
Nikolic, L., Savic, D., Korać Jačić, J., Petkovic, B., Stojadinovic, G., Martac, L.,& Bogdanović Pristov, J.. (2022). MEMBRANE CURRENTS OF C6 CELLS IN PHARMACOLOGICAL INVESTIGATION. in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings) Society of Physical Chemists of Serbia., 2, 589-592. https://hdl.handle.net/21.15107/rcub_rimsi_2010
Nikolic L, Savic D, Korać Jačić J, Petkovic B, Stojadinovic G, Martac L, Bogdanović Pristov J. MEMBRANE CURRENTS OF C6 CELLS IN PHARMACOLOGICAL INVESTIGATION. in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings). 2022;2:589-592. https://hdl.handle.net/21.15107/rcub_rimsi_2010 .
Nikolic, Ljiljana, Savic, Danijela, Korać Jačić, Jelena, Petkovic, Branka, Stojadinovic, Gordana, Martac, Ljiljana, Bogdanović Pristov, Jelena, "MEMBRANE CURRENTS OF C6 CELLS IN PHARMACOLOGICAL INVESTIGATION" in PHYSICAL CHEMISTRY 2022, 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry (Proceedings), 2 (2022):589-592, https://hdl.handle.net/21.15107/rcub_rimsi_2010 .