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Raspberry seeds extract selectively inhibits the growth of human lung cancer cells in vitro
dc.creator | Simonović, Mladen | |
dc.creator | Kojić, Vesna | |
dc.creator | Jakimov, Dimitar | |
dc.creator | Glumac, Miodrag | |
dc.creator | Pejin, Boris | |
dc.date.accessioned | 2022-04-05T15:39:32Z | |
dc.date.available | 2022-04-05T15:39:32Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1478-6419 | |
dc.identifier.uri | http://rimsi.imsi.bg.ac.rs/handle/123456789/1513 | |
dc.description.abstract | This study was focused on in vitro cytotoxicity screening of the raspberry seeds methanol extract towards a number of cancer cell lines of human origin. The tested extract at the preferred concentrations (IC50 lt 30 mu g/mL) inhibited only the growth of the lung cancer A-549 cells (IC50 = 14.07 +/- 0.96 mu g/mL). At the same time, it was practically inactive (IC50 >300 mu g/mL) and non-mutagenic towards normal MRC-5 lung cells. Finally, the extract potently scavenged both OH center dot (IC50 = 20.11 +/- 1.77 mu g/mL) and O2-center dot (IC50 = 47.23 +/- 3.82 mu g/mL), the free radicals of proved relevance for cancer pathophysiology. Though seeds were enriched with phenolic compounds (TPC = 5.21 +/- 0.07 mg GAE/g), anthocyanins were present in traces only (TAC = 0.07 +/- 0.003 mg cyn-3-glu/g), while flavonoids were not detected at all. This is the first report on anti-lung cancer potential of the seeds of any soft fruit. | en |
dc.publisher | Taylor & Francis Ltd, Abingdon | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/31093/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS// | |
dc.rights | restrictedAccess | |
dc.source | Natural Product Research | |
dc.subject | Soft fruit | en |
dc.subject | ROS | en |
dc.subject | phenolics | en |
dc.subject | MRC-5 cells | en |
dc.subject | extract | en |
dc.subject | comet assay | en |
dc.subject | A-549 cells | en |
dc.title | Raspberry seeds extract selectively inhibits the growth of human lung cancer cells in vitro | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 2256 | |
dc.citation.issue | 13 | |
dc.citation.other | 35(13): 2253-2256 | |
dc.citation.rank | M22~ | |
dc.citation.spage | 2253 | |
dc.citation.volume | 35 | |
dc.identifier.doi | 10.1080/14786419.2019.1666391 | |
dc.identifier.pmid | 31526150 | |
dc.identifier.scopus | 2-s2.0-85073999925 | |
dc.identifier.wos | 000486742800001 | |
dc.type.version | publishedVersion |
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