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Liposomal integration method for assessing antioxidative activity of water insoluble compounds towards biologically relevant free radicals: example of avarol
dc.creator | Nakarada, Dura | |
dc.creator | Pejin, Boris | |
dc.creator | Tommonaro, Giuseppina | |
dc.creator | Mojović, Miloš | |
dc.date.accessioned | 2022-04-05T15:27:44Z | |
dc.date.available | 2022-04-05T15:27:44Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0898-2104 | |
dc.identifier.uri | http://rimsi.imsi.bg.ac.rs/handle/123456789/1340 | |
dc.description.abstract | The liposomal integration method, in conjunction with electron paramagnetic resonance (EPR) spectroscopy, has been presented for the investigation of antioxidant activity of selected water-insoluble compound towards biologically relevant free radicals. This method was applied to avarol, a sesquiterpenoid hydroquinone isolated from the marine sponge Dysidea avara. The antioxidant activity of water-insoluble avarol towards (OH)-O-center dot, O-2(center dot-) and NO center dot radicals was attained by its incorporation into the DPPC liposomes bilayer, and towards ascorbyl radicals in the organic solvent. Avarol's activity towards (OH)-O-center dot, O-2(center dot-), NO center dot and ascorbyl radicals was 86.2%, 50.9%, 23.6% and 61.8%, respectively, showing its significant radical scavenging potential. | en |
dc.publisher | Taylor & Francis Ltd, Abingdon | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41005/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Liposome Research | |
dc.subject | Liposomes | en |
dc.subject | EPR | en |
dc.subject | Dysidea avara | en |
dc.subject | avarol | en |
dc.subject | antioxidant | en |
dc.title | Liposomal integration method for assessing antioxidative activity of water insoluble compounds towards biologically relevant free radicals: example of avarol | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 226 | |
dc.citation.issue | 3 | |
dc.citation.other | 30(3): 218-226 | |
dc.citation.rank | M22 | |
dc.citation.spage | 218 | |
dc.citation.volume | 30 | |
dc.identifier.doi | 10.1080/08982104.2019.1625378 | |
dc.identifier.pmid | 31146614 | |
dc.identifier.scopus | 2-s2.0-85067698469 | |
dc.identifier.wos | 000472436900001 | |
dc.type.version | publishedVersion |
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