A contribution to pharmaceutical biology of freshwater sponges
Abstract
In vitro anti-tumour and anti-radical activities of the acetone extract of the freshwater sponge Ochridaspongia rotunda were the subject of this study. The extract was found to be highly cytotoxic to human lung tumour cell line A-549 reaching IC50 value of 5.01 +/- 0.21 mu g/mL. Indeed, it displayed only 2-fold less anti-tumour activity than doxorubicin (IC50 value 2.42 +/- 0.13 mu g/mL) used as a positive control. The same extract was also found to be almost 37-fold more selective against A-549 vs. MRC-5 (normal) lung cells, in difference to weak selectivity of doxorubicin (less than 3-fold). Its profound anti-DPPH radical activity comparable to that of quercetin (IC50 values 3.68 +/- 0.19 and 3.14 +/- 0.09 mu g/mL, respectively) coupled with no signs of genotoxicity in the comet assay (MRC-5 cell line, vs. doxorubicin) has actually implicated the importance of this animal bioresource in searching for pharmaceutically useful bioactive compounds of natural origin. [GRAPHICS] .
Keywords:
Ochridaspongia rotunda / no genotoxicity / Malawispongiidae / Lake Ohrid / crude extract / anti-DPPH radical activity / A-549Source:
Natural Product Research, 2018, 32, 5, 568-571Publisher:
- Taylor & Francis Ltd, Abingdon
Funding / projects:
- Rufford Small Grants Foundation (RSG) [16062-1]
DOI: 10.1080/14786419.2017.1315719
ISSN: 1478-6419
PubMed: 28403652
WoS: 000426941200011
Scopus: 2-s2.0-85017448871
Collections
Institution/Community
Institut za multidisciplinarna istraživanjaTY - JOUR AU - Talevska, Aleksandra AU - Pejin, Boris AU - Kojić, Vesna AU - Berić, Tanja AU - Stanković, Slaviša PY - 2018 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/1149 AB - In vitro anti-tumour and anti-radical activities of the acetone extract of the freshwater sponge Ochridaspongia rotunda were the subject of this study. The extract was found to be highly cytotoxic to human lung tumour cell line A-549 reaching IC50 value of 5.01 +/- 0.21 mu g/mL. Indeed, it displayed only 2-fold less anti-tumour activity than doxorubicin (IC50 value 2.42 +/- 0.13 mu g/mL) used as a positive control. The same extract was also found to be almost 37-fold more selective against A-549 vs. MRC-5 (normal) lung cells, in difference to weak selectivity of doxorubicin (less than 3-fold). Its profound anti-DPPH radical activity comparable to that of quercetin (IC50 values 3.68 +/- 0.19 and 3.14 +/- 0.09 mu g/mL, respectively) coupled with no signs of genotoxicity in the comet assay (MRC-5 cell line, vs. doxorubicin) has actually implicated the importance of this animal bioresource in searching for pharmaceutically useful bioactive compounds of natural origin. [GRAPHICS] . PB - Taylor & Francis Ltd, Abingdon T2 - Natural Product Research T1 - A contribution to pharmaceutical biology of freshwater sponges EP - 571 IS - 5 SP - 568 VL - 32 DO - 10.1080/14786419.2017.1315719 ER -
@article{ author = "Talevska, Aleksandra and Pejin, Boris and Kojić, Vesna and Berić, Tanja and Stanković, Slaviša", year = "2018", abstract = "In vitro anti-tumour and anti-radical activities of the acetone extract of the freshwater sponge Ochridaspongia rotunda were the subject of this study. The extract was found to be highly cytotoxic to human lung tumour cell line A-549 reaching IC50 value of 5.01 +/- 0.21 mu g/mL. Indeed, it displayed only 2-fold less anti-tumour activity than doxorubicin (IC50 value 2.42 +/- 0.13 mu g/mL) used as a positive control. The same extract was also found to be almost 37-fold more selective against A-549 vs. MRC-5 (normal) lung cells, in difference to weak selectivity of doxorubicin (less than 3-fold). Its profound anti-DPPH radical activity comparable to that of quercetin (IC50 values 3.68 +/- 0.19 and 3.14 +/- 0.09 mu g/mL, respectively) coupled with no signs of genotoxicity in the comet assay (MRC-5 cell line, vs. doxorubicin) has actually implicated the importance of this animal bioresource in searching for pharmaceutically useful bioactive compounds of natural origin. [GRAPHICS] .", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Natural Product Research", title = "A contribution to pharmaceutical biology of freshwater sponges", pages = "571-568", number = "5", volume = "32", doi = "10.1080/14786419.2017.1315719" }
Talevska, A., Pejin, B., Kojić, V., Berić, T.,& Stanković, S.. (2018). A contribution to pharmaceutical biology of freshwater sponges. in Natural Product Research Taylor & Francis Ltd, Abingdon., 32(5), 568-571. https://doi.org/10.1080/14786419.2017.1315719
Talevska A, Pejin B, Kojić V, Berić T, Stanković S. A contribution to pharmaceutical biology of freshwater sponges. in Natural Product Research. 2018;32(5):568-571. doi:10.1080/14786419.2017.1315719 .
Talevska, Aleksandra, Pejin, Boris, Kojić, Vesna, Berić, Tanja, Stanković, Slaviša, "A contribution to pharmaceutical biology of freshwater sponges" in Natural Product Research, 32, no. 5 (2018):568-571, https://doi.org/10.1080/14786419.2017.1315719 . .