An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1
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Pejin, BorisCiric, Ana
Dimitrić-Marković, Jasmina
Glamočlija, Jasmina
Nikolic, Milos
Soković, Marina
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Anti-biofilm activity of three anthocyanidins (pelargonidin, cyanidin and delphinidin) was evaluated for the first time at in vitro conditions. All the compounds reduced the formation of Pseudomonas aeruginosa PAO1 biofilm at low sub-MIC (0.125 MIC) with delphinidin (c 56.25g/mL) being the most active (43%). In comparison, ampicillin (c 93.75g/mL) and streptomycin (c 21.25g/mL) (used as positive controls) were considerably less effective at the same sub-MIC (8 and 12%, respectively). Furthermore, at 0.5 MIC (c 225g/mL) this anthocyanidin molecule partly reduced the bacterial protrusions. However, no any of the aforementioned compounds inhibited the production of pyocyanin by the bacterial strain P. aeruginosa PAO1. Taken all together, the delphinidin scaffold could be taken into consideration for the design of the novel and more effective anti-biofilm agents inspired by the anthocyanidins.
Keywords:
low sub-MIC / infectious diseases / Flavanone-7-O-glucoside / delphinidin / bacterial resistance / anti-biofilm activitySource:
Natural Product Research, 2017, 31, 10, 1177-1180Publisher:
- Taylor & Francis Ltd, Abingdon
Funding / projects:
- Characterization and application of fungal metabolites and assessment of new biofungicides potential (RS-MESTD-Basic Research (BR or ON)-173032)
- Dynamics of nonlinear physicochemical and biochemical systems with modeling and predicting of their behavior under nonequilibrium conditions (RS-MESTD-Basic Research (BR or ON)-172015)
- Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-MESTD-Basic Research (BR or ON)-172053)
DOI: 10.1080/14786419.2016.1222386
ISSN: 1478-6419
PubMed: 27539815
WoS: 000395151500011
Scopus: 2-s2.0-84982276502
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Institut za multidisciplinarna istraživanjaTY - JOUR AU - Pejin, Boris AU - Ciric, Ana AU - Dimitrić-Marković, Jasmina AU - Glamočlija, Jasmina AU - Nikolic, Milos AU - Soković, Marina PY - 2017 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/1090 AB - Anti-biofilm activity of three anthocyanidins (pelargonidin, cyanidin and delphinidin) was evaluated for the first time at in vitro conditions. All the compounds reduced the formation of Pseudomonas aeruginosa PAO1 biofilm at low sub-MIC (0.125 MIC) with delphinidin (c 56.25g/mL) being the most active (43%). In comparison, ampicillin (c 93.75g/mL) and streptomycin (c 21.25g/mL) (used as positive controls) were considerably less effective at the same sub-MIC (8 and 12%, respectively). Furthermore, at 0.5 MIC (c 225g/mL) this anthocyanidin molecule partly reduced the bacterial protrusions. However, no any of the aforementioned compounds inhibited the production of pyocyanin by the bacterial strain P. aeruginosa PAO1. Taken all together, the delphinidin scaffold could be taken into consideration for the design of the novel and more effective anti-biofilm agents inspired by the anthocyanidins. PB - Taylor & Francis Ltd, Abingdon T2 - Natural Product Research T1 - An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1 EP - 1180 IS - 10 SP - 1177 VL - 31 DO - 10.1080/14786419.2016.1222386 ER -
@article{ author = "Pejin, Boris and Ciric, Ana and Dimitrić-Marković, Jasmina and Glamočlija, Jasmina and Nikolic, Milos and Soković, Marina", year = "2017", abstract = "Anti-biofilm activity of three anthocyanidins (pelargonidin, cyanidin and delphinidin) was evaluated for the first time at in vitro conditions. All the compounds reduced the formation of Pseudomonas aeruginosa PAO1 biofilm at low sub-MIC (0.125 MIC) with delphinidin (c 56.25g/mL) being the most active (43%). In comparison, ampicillin (c 93.75g/mL) and streptomycin (c 21.25g/mL) (used as positive controls) were considerably less effective at the same sub-MIC (8 and 12%, respectively). Furthermore, at 0.5 MIC (c 225g/mL) this anthocyanidin molecule partly reduced the bacterial protrusions. However, no any of the aforementioned compounds inhibited the production of pyocyanin by the bacterial strain P. aeruginosa PAO1. Taken all together, the delphinidin scaffold could be taken into consideration for the design of the novel and more effective anti-biofilm agents inspired by the anthocyanidins.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Natural Product Research", title = "An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1", pages = "1180-1177", number = "10", volume = "31", doi = "10.1080/14786419.2016.1222386" }
Pejin, B., Ciric, A., Dimitrić-Marković, J., Glamočlija, J., Nikolic, M.,& Soković, M.. (2017). An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1. in Natural Product Research Taylor & Francis Ltd, Abingdon., 31(10), 1177-1180. https://doi.org/10.1080/14786419.2016.1222386
Pejin B, Ciric A, Dimitrić-Marković J, Glamočlija J, Nikolic M, Soković M. An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1. in Natural Product Research. 2017;31(10):1177-1180. doi:10.1080/14786419.2016.1222386 .
Pejin, Boris, Ciric, Ana, Dimitrić-Marković, Jasmina, Glamočlija, Jasmina, Nikolic, Milos, Soković, Marina, "An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1" in Natural Product Research, 31, no. 10 (2017):1177-1180, https://doi.org/10.1080/14786419.2016.1222386 . .