Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment
Samo za registrovane korisnike
2016
Autori
Spasojević, DragicaZmejkoski, Danica
Glamočlija, Jasmina
Nikolic, Milos
Soković, Marina
Milošević, Verica Lj.
Jaric, Ivana
Stojanović, Marijana
Marinković, Emilija
Barisani-Asenbauer, Talin
Prodanović, Radivoje
Jovanović, Milos
Radotić, Ksenija
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Nowadays bacterial resistance to known antibiotics is a serious health problem. In order to achieve more efficient treatment, lately there is an effort to find new substances, such as certain biomaterials, that are non-toxic to humans with antibiotic potential. Lignins and lignin-derived compounds have been proposed to be good candidates for use in medicine and health maintenance. In this study, the antibacterial activity of the lignin model polymer dehydrogenate polymer (DHP) in alginate hydrogel (Alg) was studied. The obtained results show that DHP-Alg has strong antimicrobial activity against several bacterial strains and biofilms and does not have a toxic effect on human epithelial cells. These results strongly suggest its application as a wound healing agent or as an adjunct substance for wound treatments.
Ključne reči:
Wound treatment / Lignin model polymer / Bacterial biofilm / Antimicrobial activity / AlginateIzvor:
International Journal of Antimicrobial Agents, 2016, 48, 6, 732-735Izdavač:
- Elsevier, Amsterdam
Finansiranje / projekti:
- Sinteza, procesiranje i karakterizacija nanostrukturnih materijala za primenu u oblasti energije, mehaničkog inženjerstva, zaštite životne stredine i biomedicine (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45012)
- Ispitivanja odnosa struktura-funkcija u ćelijskom zidu biljaka i izmene strukture zida enzimskim inženjeringom (RS-MESTD-Basic Research (BR or ON)-173017)
- Karakterizacija i primena metabolita gljiva i utvrđivanje potencijala novih biofungicida (RS-MESTD-Basic Research (BR or ON)-173032)
- Alergeni, antitela, enzimi i mali fiziološki značajni molekuli: dizajn, struktura, funkcija i značaj (RS-MESTD-Basic Research (BR or ON)-172049)
DOI: 10.1016/j.ijantimicag.2016.08.014
ISSN: 0924-8579
PubMed: 27742207
WoS: 000389520700024
Scopus: 2-s2.0-85000995852
Institucija/grupa
Institut za multidisciplinarna istraživanjaTY - JOUR AU - Spasojević, Dragica AU - Zmejkoski, Danica AU - Glamočlija, Jasmina AU - Nikolic, Milos AU - Soković, Marina AU - Milošević, Verica Lj. AU - Jaric, Ivana AU - Stojanović, Marijana AU - Marinković, Emilija AU - Barisani-Asenbauer, Talin AU - Prodanović, Radivoje AU - Jovanović, Milos AU - Radotić, Ksenija PY - 2016 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/983 AB - Nowadays bacterial resistance to known antibiotics is a serious health problem. In order to achieve more efficient treatment, lately there is an effort to find new substances, such as certain biomaterials, that are non-toxic to humans with antibiotic potential. Lignins and lignin-derived compounds have been proposed to be good candidates for use in medicine and health maintenance. In this study, the antibacterial activity of the lignin model polymer dehydrogenate polymer (DHP) in alginate hydrogel (Alg) was studied. The obtained results show that DHP-Alg has strong antimicrobial activity against several bacterial strains and biofilms and does not have a toxic effect on human epithelial cells. These results strongly suggest its application as a wound healing agent or as an adjunct substance for wound treatments. PB - Elsevier, Amsterdam T2 - International Journal of Antimicrobial Agents T1 - Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment EP - 735 IS - 6 SP - 732 VL - 48 DO - 10.1016/j.ijantimicag.2016.08.014 ER -
@article{ author = "Spasojević, Dragica and Zmejkoski, Danica and Glamočlija, Jasmina and Nikolic, Milos and Soković, Marina and Milošević, Verica Lj. and Jaric, Ivana and Stojanović, Marijana and Marinković, Emilija and Barisani-Asenbauer, Talin and Prodanović, Radivoje and Jovanović, Milos and Radotić, Ksenija", year = "2016", abstract = "Nowadays bacterial resistance to known antibiotics is a serious health problem. In order to achieve more efficient treatment, lately there is an effort to find new substances, such as certain biomaterials, that are non-toxic to humans with antibiotic potential. Lignins and lignin-derived compounds have been proposed to be good candidates for use in medicine and health maintenance. In this study, the antibacterial activity of the lignin model polymer dehydrogenate polymer (DHP) in alginate hydrogel (Alg) was studied. The obtained results show that DHP-Alg has strong antimicrobial activity against several bacterial strains and biofilms and does not have a toxic effect on human epithelial cells. These results strongly suggest its application as a wound healing agent or as an adjunct substance for wound treatments.", publisher = "Elsevier, Amsterdam", journal = "International Journal of Antimicrobial Agents", title = "Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment", pages = "735-732", number = "6", volume = "48", doi = "10.1016/j.ijantimicag.2016.08.014" }
Spasojević, D., Zmejkoski, D., Glamočlija, J., Nikolic, M., Soković, M., Milošević, V. Lj., Jaric, I., Stojanović, M., Marinković, E., Barisani-Asenbauer, T., Prodanović, R., Jovanović, M.,& Radotić, K.. (2016). Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment. in International Journal of Antimicrobial Agents Elsevier, Amsterdam., 48(6), 732-735. https://doi.org/10.1016/j.ijantimicag.2016.08.014
Spasojević D, Zmejkoski D, Glamočlija J, Nikolic M, Soković M, Milošević VL, Jaric I, Stojanović M, Marinković E, Barisani-Asenbauer T, Prodanović R, Jovanović M, Radotić K. Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment. in International Journal of Antimicrobial Agents. 2016;48(6):732-735. doi:10.1016/j.ijantimicag.2016.08.014 .
Spasojević, Dragica, Zmejkoski, Danica, Glamočlija, Jasmina, Nikolic, Milos, Soković, Marina, Milošević, Verica Lj., Jaric, Ivana, Stojanović, Marijana, Marinković, Emilija, Barisani-Asenbauer, Talin, Prodanović, Radivoje, Jovanović, Milos, Radotić, Ksenija, "Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment" in International Journal of Antimicrobial Agents, 48, no. 6 (2016):732-735, https://doi.org/10.1016/j.ijantimicag.2016.08.014 . .