Inappropriately chelated iron in the cerebrospinal fluid of amyotrophic lateral sclerosis patients
Nema prikaza
Autori
Ignjatović, AleksandarStević, Zorica D
Lavrnic, Dragana S
Nikolić-Kokić, Aleksandra
Blagojević, Duško P
Spasić, Mihajlo
Spasojević, Ivan
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
ALS is characterized by oxidative damage in the brain and cerebrospinal fluid, which is exerted by pro-oxidative activity of iron. Such activity of iron can be drastically increased in the presence of inappropriate iron ligands that catalyze redox cycling of iron, thereby promoting hydroxyl radical generation. The aim of our study was to determine the relative level of inappropriate iron ligands in the cerebrospinal fluid of ALS patients. To determine the levels of inappropriate iron ligands and redox activity of iron in cerebrospinal fluid (10 samples from ALS patients and 10 controls), we applied electron paramagnetic resonance spectroscopy. We have shown that cerebrospinal fluid of ALS patients comprises twofold increased level of inappropriate iron ligands, proportionally increasing iron redox activity and hydroxyl radical production compared to controls. In conclusion, our results strongly support the pro-oxidative/detrimental role of inappropriately chelated iron in ALS pathophys...iology. The identification of biomolecules that form such iron complexes and their therapeutic targeting may represent the future of ALS treatment.
Ključne reči:
oxidative stress / ligands / iron / cerebrospinal fluid / Amyotrophic lateral sclerosisIzvor:
Amyotrophic Lateral Sclerosis, 2012, 13, 4, 357-362Izdavač:
- Informa Healthcare, London
Finansiranje / projekti:
- Ispitivanje molekularno-genetskih, patohistoloških i biohemijskih karakteristika neuromišićnih bolesti (RS-MESTD-Basic Research (BR or ON)-175083)
- Molekularni mehanizmi redoks signalinga u homeostazi, adaptaciji i patologiji (RS-MESTD-Basic Research (BR or ON)-173014)
DOI: 10.3109/17482968.2012.665929
ISSN: 1748-2968
PubMed: 22424123
WoS: 000304521600005
Scopus: 2-s2.0-84861640240
Institucija/grupa
Institut za multidisciplinarna istraživanjaTY - JOUR AU - Ignjatović, Aleksandar AU - Stević, Zorica D AU - Lavrnic, Dragana S AU - Nikolić-Kokić, Aleksandra AU - Blagojević, Duško P AU - Spasić, Mihajlo AU - Spasojević, Ivan PY - 2012 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/535 AB - ALS is characterized by oxidative damage in the brain and cerebrospinal fluid, which is exerted by pro-oxidative activity of iron. Such activity of iron can be drastically increased in the presence of inappropriate iron ligands that catalyze redox cycling of iron, thereby promoting hydroxyl radical generation. The aim of our study was to determine the relative level of inappropriate iron ligands in the cerebrospinal fluid of ALS patients. To determine the levels of inappropriate iron ligands and redox activity of iron in cerebrospinal fluid (10 samples from ALS patients and 10 controls), we applied electron paramagnetic resonance spectroscopy. We have shown that cerebrospinal fluid of ALS patients comprises twofold increased level of inappropriate iron ligands, proportionally increasing iron redox activity and hydroxyl radical production compared to controls. In conclusion, our results strongly support the pro-oxidative/detrimental role of inappropriately chelated iron in ALS pathophysiology. The identification of biomolecules that form such iron complexes and their therapeutic targeting may represent the future of ALS treatment. PB - Informa Healthcare, London T2 - Amyotrophic Lateral Sclerosis T1 - Inappropriately chelated iron in the cerebrospinal fluid of amyotrophic lateral sclerosis patients EP - 362 IS - 4 SP - 357 VL - 13 DO - 10.3109/17482968.2012.665929 ER -
@article{ author = "Ignjatović, Aleksandar and Stević, Zorica D and Lavrnic, Dragana S and Nikolić-Kokić, Aleksandra and Blagojević, Duško P and Spasić, Mihajlo and Spasojević, Ivan", year = "2012", abstract = "ALS is characterized by oxidative damage in the brain and cerebrospinal fluid, which is exerted by pro-oxidative activity of iron. Such activity of iron can be drastically increased in the presence of inappropriate iron ligands that catalyze redox cycling of iron, thereby promoting hydroxyl radical generation. The aim of our study was to determine the relative level of inappropriate iron ligands in the cerebrospinal fluid of ALS patients. To determine the levels of inappropriate iron ligands and redox activity of iron in cerebrospinal fluid (10 samples from ALS patients and 10 controls), we applied electron paramagnetic resonance spectroscopy. We have shown that cerebrospinal fluid of ALS patients comprises twofold increased level of inappropriate iron ligands, proportionally increasing iron redox activity and hydroxyl radical production compared to controls. In conclusion, our results strongly support the pro-oxidative/detrimental role of inappropriately chelated iron in ALS pathophysiology. The identification of biomolecules that form such iron complexes and their therapeutic targeting may represent the future of ALS treatment.", publisher = "Informa Healthcare, London", journal = "Amyotrophic Lateral Sclerosis", title = "Inappropriately chelated iron in the cerebrospinal fluid of amyotrophic lateral sclerosis patients", pages = "362-357", number = "4", volume = "13", doi = "10.3109/17482968.2012.665929" }
Ignjatović, A., Stević, Z. D., Lavrnic, D. S., Nikolić-Kokić, A., Blagojević, D. P., Spasić, M.,& Spasojević, I.. (2012). Inappropriately chelated iron in the cerebrospinal fluid of amyotrophic lateral sclerosis patients. in Amyotrophic Lateral Sclerosis Informa Healthcare, London., 13(4), 357-362. https://doi.org/10.3109/17482968.2012.665929
Ignjatović A, Stević ZD, Lavrnic DS, Nikolić-Kokić A, Blagojević DP, Spasić M, Spasojević I. Inappropriately chelated iron in the cerebrospinal fluid of amyotrophic lateral sclerosis patients. in Amyotrophic Lateral Sclerosis. 2012;13(4):357-362. doi:10.3109/17482968.2012.665929 .
Ignjatović, Aleksandar, Stević, Zorica D, Lavrnic, Dragana S, Nikolić-Kokić, Aleksandra, Blagojević, Duško P, Spasić, Mihajlo, Spasojević, Ivan, "Inappropriately chelated iron in the cerebrospinal fluid of amyotrophic lateral sclerosis patients" in Amyotrophic Lateral Sclerosis, 13, no. 4 (2012):357-362, https://doi.org/10.3109/17482968.2012.665929 . .