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Penicillamine prevents damaging redox in vitro interactions of bilirubin and copper
dc.creator | Bozic Cvijan, Bojana | |
dc.creator | Korać Jačić, Jelena | |
dc.creator | Stanković, Dalibor | |
dc.creator | Stanić, Marina | |
dc.creator | Popovic Bijelic, Ana | |
dc.creator | Bogdanović Pristov, Jelena | |
dc.creator | Spasojević, Ivan | |
dc.creator | Bajcetic, Milica | |
dc.date.accessioned | 2023-12-08T08:29:19Z | |
dc.date.available | 2023-12-08T08:29:19Z | |
dc.date.issued | 2019 | |
dc.identifier.isbn | 978-86-80244-01-3 | |
dc.identifier.uri | http://rimsi.imsi.bg.ac.rs/handle/123456789/2847 | |
dc.description.abstract | Toxic effects of unconjugated bilirubin (BR) in neonatal hyperbilirubinemia have been related to redox and/or coordinate interactions with Cu2+. However, the development and mechanisms of such interactions at physiological pH have not been resolved. This study shows that BR reduces Cu2+ to Cu1+ in 1:1 stoichiometry. Apparently, BR undergoes degradation, i.e. BR and Cu2+ do not form stable complexes. The binding of Cu2+ to inorganic phosphates, liposomal phosphate groups, or to chelating drug penicillamine, impedes redox interactions with BR. Cu1+ undergoes spontaneous oxidation by O2 resulting in hydrogen peroxide accumulation and hydroxyl radical production. In relation to this, copper and BR induced synergistic oxidative/damaging effects on erythrocytes membrane, which were alleviated by penicillamine. The production of reactive oxygen species by BR and copper represents a plausible cause of BR toxic effects and cell damage in hyperbilirubinemia. Further examination of therapeutic potentials of copper chelators in the treatment of severe neonatal hyperbilirubinemia is needed. | sr |
dc.language.iso | en | sr |
dc.publisher | Srpsko farmakološko društvo Beograd, Novi Sad | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | 14th Serbian Congress of Farmacologists and 4th Serbian Congress of Clinical Pharmacology with international participation | sr |
dc.subject | Penicillamine | |
dc.subject | bilirubin | |
dc.subject | copper | |
dc.title | Penicillamine prevents damaging redox in vitro interactions of bilirubin and copper | sr |
dc.type | conferenceObject | sr |
dc.rights.license | BY | sr |
dc.citation.epage | 242 | |
dc.citation.spage | 240 | |
dc.identifier.fulltext | http://rimsi.imsi.bg.ac.rs/bitstream/id/7271/bitstream_7271.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_rimsi_2847 | |
dc.type.version | publishedVersion | sr |