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(Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines
| dc.creator | Todorović, Tamara | |
| dc.creator | Vukašinović, Jelena | |
| dc.creator | Portalone, Gustavo | |
| dc.creator | suleiman, sherif | |
| dc.creator | Gligorijević, Nevenka | |
| dc.creator | Bjelogrlic, Snezana K. | |
| dc.creator | Jovanovic, Katarina | |
| dc.creator | Radulović, Sinisa S | |
| dc.creator | Andjelkovic, Katarina | |
| dc.creator | Cassar, Analisse | |
| dc.creator | Filipović, Nenad | |
| dc.creator | Schembri-WIsmayer, Pierre | |
| dc.date.accessioned | 2023-08-02T09:26:23Z | |
| dc.date.available | 2023-08-02T09:26:23Z | |
| dc.date.issued | 2017 | |
| dc.identifier.issn | 2040-2511 | |
| dc.identifier.uri | http://rimsi.imsi.bg.ac.rs/handle/123456789/2027 | |
| dc.description.abstract | Cobaltcomplexeswithsemi-andthiosemicarbazonesof8-quinolinecarboxaldehydehavebeensynthesizedandcharacterizedbyX-raydiffractionanalysis.Thesenovelcomplexesandapreviouslysynthesized cobaltcomplexwithaselenium-basedselenosemicarbazoneligandshowedmyeloiddifferentiationactivity onalltransretinoicacidresistantHL-60acutemyeloidleukaemiacells.Theyalsoshowedvaryinglevelsof cytotoxicityonfivehumantumorcelllines:cervixcarcinomacells(HeLa),lungadenocarcinomacells (A549),colorectaladenocarcinomacells(LS-174),breastcarcinomacells(MDA-MB-361),andchronicmyeloidleukaemia(K562)aswellasonenormalhumancellline:fetallungfibroblastcells(MRC-5).Leukaemia differentiationwasmoststronglyinducedbyametal-freeoxygenligandandtheseleniumligand,whilst thelatterandthecobaltIJII)complexwithanoxygenligandshowedthestrongestdose-dependentcytotoxic activity.Infouroutoffiveinvestigatedtumorcelllines,itwasofthesameorderofmagnitudeascisplatin. Thesebestcompounds,however,hadlowertoxicityonnon-transformedMRC-5cellsthancisplatin. | sr |
| dc.language.iso | en | sr |
| dc.publisher | RSC Publishing | sr |
| dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS// | sr |
| dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS// | sr |
| dc.rights | openAccess | sr |
| dc.source | MedChemComm | sr |
| dc.subject | (Chalcogen)semicarbazones | sr |
| dc.subject | Cobalt complexes | sr |
| dc.subject | X-ray diffraction | sr |
| dc.subject | DNA | sr |
| dc.subject | Cytotoxic effect | sr |
| dc.title | (Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines | sr |
| dc.type | article | sr |
| dc.rights.license | ARR | sr |
| dc.citation.epage | 111 | |
| dc.citation.issue | 1 | |
| dc.citation.spage | 103 | |
| dc.citation.volume | 8 | |
| dc.identifier.doi | https://doi.org/10.1039/c6md00501b | |
| dc.identifier.fulltext | http://rimsi.imsi.bg.ac.rs/bitstream/id/5341/MedChemComm2017.pdf | |
| dc.type.version | acceptedVersion | sr |
