KINETIC RELEASE STUDY OF SYNTHETIC LIGNIN (DHP) FROM CALCIUM ALGINATE BEADS
Само за регистроване кориснике
2022
Аутори
Spasojević, DragicaMutavdžić, Dragosav
Simonović Radosavljević, Jasna
Mitrović, Aleksandra Lj.
Đikanović, Daniela
Radotić, Ksenija
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Controlled drug delivery systems are of great interest in modern science and medicine. This study was oriented towards encapsulation of synthetic lignin (DHP) into alginate beads and investigation of its release kinetic. Encapsulation was achieved by the ionotropic gelation method. In vitro release profiles were fitted into four release kinetic models (zero-order, first-order, Higuchi, and Korsmeyer-Peppas). According to the in vitro release, data alginate beads showed initial burst release followed by prolonged release. The best correlation was found for the Korsmeyer-Peppas model (R2 = 0.948), with an n value lower than 0.43, indicating the DHP transport mechanism was controlled by quasi-Fickian diffusion. This delivery system could be promising for chronic wound care and antibacterial treatment.
Кључне речи:
synthetic lignin / alginate beads / kinetic modelsИзвор:
16th International Conference on Fundamental and Applied Aspects of Physical Chemistry, 2022, 2Издавач:
- Society of Physical Chemists of Serbia
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200053 (Универзитет у Београду, Институт за мултидисциплинарна истраживања) (RS-MESTD-inst-2020-200053)
Институција/група
Institut za multidisciplinarna istraživanjaTY - CONF AU - Spasojević, Dragica AU - Mutavdžić, Dragosav AU - Simonović Radosavljević, Jasna AU - Mitrović, Aleksandra Lj. AU - Đikanović, Daniela AU - Radotić, Ksenija PY - 2022 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/1749 AB - Controlled drug delivery systems are of great interest in modern science and medicine. This study was oriented towards encapsulation of synthetic lignin (DHP) into alginate beads and investigation of its release kinetic. Encapsulation was achieved by the ionotropic gelation method. In vitro release profiles were fitted into four release kinetic models (zero-order, first-order, Higuchi, and Korsmeyer-Peppas). According to the in vitro release, data alginate beads showed initial burst release followed by prolonged release. The best correlation was found for the Korsmeyer-Peppas model (R2 = 0.948), with an n value lower than 0.43, indicating the DHP transport mechanism was controlled by quasi-Fickian diffusion. This delivery system could be promising for chronic wound care and antibacterial treatment. PB - Society of Physical Chemists of Serbia C3 - 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry T1 - KINETIC RELEASE STUDY OF SYNTHETIC LIGNIN (DHP) FROM CALCIUM ALGINATE BEADS VL - 2 UR - https://hdl.handle.net/21.15107/rcub_rimsi_1749 ER -
@conference{ author = "Spasojević, Dragica and Mutavdžić, Dragosav and Simonović Radosavljević, Jasna and Mitrović, Aleksandra Lj. and Đikanović, Daniela and Radotić, Ksenija", year = "2022", abstract = "Controlled drug delivery systems are of great interest in modern science and medicine. This study was oriented towards encapsulation of synthetic lignin (DHP) into alginate beads and investigation of its release kinetic. Encapsulation was achieved by the ionotropic gelation method. In vitro release profiles were fitted into four release kinetic models (zero-order, first-order, Higuchi, and Korsmeyer-Peppas). According to the in vitro release, data alginate beads showed initial burst release followed by prolonged release. The best correlation was found for the Korsmeyer-Peppas model (R2 = 0.948), with an n value lower than 0.43, indicating the DHP transport mechanism was controlled by quasi-Fickian diffusion. This delivery system could be promising for chronic wound care and antibacterial treatment.", publisher = "Society of Physical Chemists of Serbia", journal = "16th International Conference on Fundamental and Applied Aspects of Physical Chemistry", title = "KINETIC RELEASE STUDY OF SYNTHETIC LIGNIN (DHP) FROM CALCIUM ALGINATE BEADS", volume = "2", url = "https://hdl.handle.net/21.15107/rcub_rimsi_1749" }
Spasojević, D., Mutavdžić, D., Simonović Radosavljević, J., Mitrović, A. Lj., Đikanović, D.,& Radotić, K.. (2022). KINETIC RELEASE STUDY OF SYNTHETIC LIGNIN (DHP) FROM CALCIUM ALGINATE BEADS. in 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry Society of Physical Chemists of Serbia., 2. https://hdl.handle.net/21.15107/rcub_rimsi_1749
Spasojević D, Mutavdžić D, Simonović Radosavljević J, Mitrović AL, Đikanović D, Radotić K. KINETIC RELEASE STUDY OF SYNTHETIC LIGNIN (DHP) FROM CALCIUM ALGINATE BEADS. in 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry. 2022;2. https://hdl.handle.net/21.15107/rcub_rimsi_1749 .
Spasojević, Dragica, Mutavdžić, Dragosav, Simonović Radosavljević, Jasna, Mitrović, Aleksandra Lj., Đikanović, Daniela, Radotić, Ksenija, "KINETIC RELEASE STUDY OF SYNTHETIC LIGNIN (DHP) FROM CALCIUM ALGINATE BEADS" in 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry, 2 (2022), https://hdl.handle.net/21.15107/rcub_rimsi_1749 .