Effects of 5-fluorouracil on erythrocytes in relation to its cardiotoxicity: Membrane structure and functioning
Само за регистроване кориснике
2005
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In the present study, we showed that the antineoplastic drug 5-fluorouracil (5-FU) induces in vitro exposure-time/dose-dependent changes on the level of an erythrocyte's morphology, ionic balance, and membrane fluidity. These changes are partially or fully irreversible, and we suggest that they are provoked by an irreversible depletion of ATP. Because of these changes that could also occur in vivo during 5-FU infusion, a certain amount of erythrocytes with echinocytic shape and diminished ability to deliver oxygen is present in blood for longer periods of time. This renders oxygen transport and delivery more difficult, leaving the heart with an insufficient supply of oxygen, thus leading to cardiotoxicity.
Кључне речи:
5-fluorouracil / cytostatic / cardiotoxicity / membrane fluidity / EPR / spin labelИзвор:
Journal of Chemical Information and Modeling, 2005, 45, 6, 1680-1685Издавач:
- Amer Chemical Soc, Washington
DOI: 10.1021/ci0501746
ISSN: 1549-9596
PubMed: 16309273
WoS: 000233689400031
Scopus: 2-s2.0-28944432545
Институција/група
Institut za multidisciplinarna istraživanjaTY - JOUR AU - Spasojević, Ivan AU - Maksimović, Vuk AU - Zakrzewska, Joanna AU - Bačić, Goran PY - 2005 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/140 AB - In the present study, we showed that the antineoplastic drug 5-fluorouracil (5-FU) induces in vitro exposure-time/dose-dependent changes on the level of an erythrocyte's morphology, ionic balance, and membrane fluidity. These changes are partially or fully irreversible, and we suggest that they are provoked by an irreversible depletion of ATP. Because of these changes that could also occur in vivo during 5-FU infusion, a certain amount of erythrocytes with echinocytic shape and diminished ability to deliver oxygen is present in blood for longer periods of time. This renders oxygen transport and delivery more difficult, leaving the heart with an insufficient supply of oxygen, thus leading to cardiotoxicity. PB - Amer Chemical Soc, Washington T2 - Journal of Chemical Information and Modeling T1 - Effects of 5-fluorouracil on erythrocytes in relation to its cardiotoxicity: Membrane structure and functioning EP - 1685 IS - 6 SP - 1680 VL - 45 DO - 10.1021/ci0501746 ER -
@article{ author = "Spasojević, Ivan and Maksimović, Vuk and Zakrzewska, Joanna and Bačić, Goran", year = "2005", abstract = "In the present study, we showed that the antineoplastic drug 5-fluorouracil (5-FU) induces in vitro exposure-time/dose-dependent changes on the level of an erythrocyte's morphology, ionic balance, and membrane fluidity. These changes are partially or fully irreversible, and we suggest that they are provoked by an irreversible depletion of ATP. Because of these changes that could also occur in vivo during 5-FU infusion, a certain amount of erythrocytes with echinocytic shape and diminished ability to deliver oxygen is present in blood for longer periods of time. This renders oxygen transport and delivery more difficult, leaving the heart with an insufficient supply of oxygen, thus leading to cardiotoxicity.", publisher = "Amer Chemical Soc, Washington", journal = "Journal of Chemical Information and Modeling", title = "Effects of 5-fluorouracil on erythrocytes in relation to its cardiotoxicity: Membrane structure and functioning", pages = "1685-1680", number = "6", volume = "45", doi = "10.1021/ci0501746" }
Spasojević, I., Maksimović, V., Zakrzewska, J.,& Bačić, G.. (2005). Effects of 5-fluorouracil on erythrocytes in relation to its cardiotoxicity: Membrane structure and functioning. in Journal of Chemical Information and Modeling Amer Chemical Soc, Washington., 45(6), 1680-1685. https://doi.org/10.1021/ci0501746
Spasojević I, Maksimović V, Zakrzewska J, Bačić G. Effects of 5-fluorouracil on erythrocytes in relation to its cardiotoxicity: Membrane structure and functioning. in Journal of Chemical Information and Modeling. 2005;45(6):1680-1685. doi:10.1021/ci0501746 .
Spasojević, Ivan, Maksimović, Vuk, Zakrzewska, Joanna, Bačić, Goran, "Effects of 5-fluorouracil on erythrocytes in relation to its cardiotoxicity: Membrane structure and functioning" in Journal of Chemical Information and Modeling, 45, no. 6 (2005):1680-1685, https://doi.org/10.1021/ci0501746 . .