Coordinate and redox interactions of epinephrine with ferric and ferrous iron at physiological pH
2018
Преузимање 🢃
Аутори
Korać Jačić, JelenaStanković, Dalibor M.
Stanić, Marina
Bajuk-Bogdanović, Danica
Žižić, Milan
Bogdanović Pristov, Jelena
Grguric-Sipka, Sanja
Popovic-Bijelic, Ana
Spasojević, Ivan
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Coordinate and redox interactions of epinephrine (Epi) with iron at physiological pH are essential for understanding two very different phenomena - the detrimental effects of chronic stress on the cardiovascular system and the cross-linking of catecholamine-rich biopolymers and frameworks. Here we show that Epi and Fe3+ form stable high-spin complexes in the 1:1 or 3:1 stoichiometry, depending on the Epi/Fe3+ concentration ratio (low or high). Oxygen atoms on the catechol ring represent the sites of coordinate bond formation within physiologically relevant bidentate 1:1 complex. Redox properties of Epi are slightly impacted by Fe3+. On the other hand, Epi and Fe2+ form a complex that acts as a strong reducing agent, which leads to the production of hydrogen peroxide via O-2 reduction, and to a facilitated formation of the Epi-Fe3+ complexes. Epi is not oxidized in this process, i.e. Fe2+ is not an electron shuttle, but the electron donor. Epi-catalyzed oxidation of Fe2+ represents a pl...ausible chemical basis of stress-related damage to heart cells. In addition, our results support the previous findings on the interactions of catecholamine moieties in polymers with iron and provide a novel strategy for improving the efficiency of cross-linking.
Кључне речи:
epinephrine / iron complex / redox interaction / physiological pHИзвор:
Scientific Reports, 2018, 8Издавач:
- Nature Publishing Group, London
Финансирање / пројекти:
- Испитивања односа структура-функција у ћелијском зиду биљака и измене структуре зида ензимским инжењерингом (RS-MESTD-Basic Research (BR or ON)-173017)
- Magbiovin project [621375]
DOI: 10.1038/s41598-018-21940-7
ISSN: 2045-2322
PubMed: 29476145
WoS: 000425934200018
Scopus: 2-s2.0-85042549576
Институција/група
Institut za multidisciplinarna istraživanjaTY - JOUR AU - Korać Jačić, Jelena AU - Stanković, Dalibor M. AU - Stanić, Marina AU - Bajuk-Bogdanović, Danica AU - Žižić, Milan AU - Bogdanović Pristov, Jelena AU - Grguric-Sipka, Sanja AU - Popovic-Bijelic, Ana AU - Spasojević, Ivan PY - 2018 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/1138 AB - Coordinate and redox interactions of epinephrine (Epi) with iron at physiological pH are essential for understanding two very different phenomena - the detrimental effects of chronic stress on the cardiovascular system and the cross-linking of catecholamine-rich biopolymers and frameworks. Here we show that Epi and Fe3+ form stable high-spin complexes in the 1:1 or 3:1 stoichiometry, depending on the Epi/Fe3+ concentration ratio (low or high). Oxygen atoms on the catechol ring represent the sites of coordinate bond formation within physiologically relevant bidentate 1:1 complex. Redox properties of Epi are slightly impacted by Fe3+. On the other hand, Epi and Fe2+ form a complex that acts as a strong reducing agent, which leads to the production of hydrogen peroxide via O-2 reduction, and to a facilitated formation of the Epi-Fe3+ complexes. Epi is not oxidized in this process, i.e. Fe2+ is not an electron shuttle, but the electron donor. Epi-catalyzed oxidation of Fe2+ represents a plausible chemical basis of stress-related damage to heart cells. In addition, our results support the previous findings on the interactions of catecholamine moieties in polymers with iron and provide a novel strategy for improving the efficiency of cross-linking. PB - Nature Publishing Group, London T2 - Scientific Reports T1 - Coordinate and redox interactions of epinephrine with ferric and ferrous iron at physiological pH VL - 8 DO - 10.1038/s41598-018-21940-7 ER -
@article{ author = "Korać Jačić, Jelena and Stanković, Dalibor M. and Stanić, Marina and Bajuk-Bogdanović, Danica and Žižić, Milan and Bogdanović Pristov, Jelena and Grguric-Sipka, Sanja and Popovic-Bijelic, Ana and Spasojević, Ivan", year = "2018", abstract = "Coordinate and redox interactions of epinephrine (Epi) with iron at physiological pH are essential for understanding two very different phenomena - the detrimental effects of chronic stress on the cardiovascular system and the cross-linking of catecholamine-rich biopolymers and frameworks. Here we show that Epi and Fe3+ form stable high-spin complexes in the 1:1 or 3:1 stoichiometry, depending on the Epi/Fe3+ concentration ratio (low or high). Oxygen atoms on the catechol ring represent the sites of coordinate bond formation within physiologically relevant bidentate 1:1 complex. Redox properties of Epi are slightly impacted by Fe3+. On the other hand, Epi and Fe2+ form a complex that acts as a strong reducing agent, which leads to the production of hydrogen peroxide via O-2 reduction, and to a facilitated formation of the Epi-Fe3+ complexes. Epi is not oxidized in this process, i.e. Fe2+ is not an electron shuttle, but the electron donor. Epi-catalyzed oxidation of Fe2+ represents a plausible chemical basis of stress-related damage to heart cells. In addition, our results support the previous findings on the interactions of catecholamine moieties in polymers with iron and provide a novel strategy for improving the efficiency of cross-linking.", publisher = "Nature Publishing Group, London", journal = "Scientific Reports", title = "Coordinate and redox interactions of epinephrine with ferric and ferrous iron at physiological pH", volume = "8", doi = "10.1038/s41598-018-21940-7" }
Korać Jačić, J., Stanković, D. M., Stanić, M., Bajuk-Bogdanović, D., Žižić, M., Bogdanović Pristov, J., Grguric-Sipka, S., Popovic-Bijelic, A.,& Spasojević, I.. (2018). Coordinate and redox interactions of epinephrine with ferric and ferrous iron at physiological pH. in Scientific Reports Nature Publishing Group, London., 8. https://doi.org/10.1038/s41598-018-21940-7
Korać Jačić J, Stanković DM, Stanić M, Bajuk-Bogdanović D, Žižić M, Bogdanović Pristov J, Grguric-Sipka S, Popovic-Bijelic A, Spasojević I. Coordinate and redox interactions of epinephrine with ferric and ferrous iron at physiological pH. in Scientific Reports. 2018;8. doi:10.1038/s41598-018-21940-7 .
Korać Jačić, Jelena, Stanković, Dalibor M., Stanić, Marina, Bajuk-Bogdanović, Danica, Žižić, Milan, Bogdanović Pristov, Jelena, Grguric-Sipka, Sanja, Popovic-Bijelic, Ana, Spasojević, Ivan, "Coordinate and redox interactions of epinephrine with ferric and ferrous iron at physiological pH" in Scientific Reports, 8 (2018), https://doi.org/10.1038/s41598-018-21940-7 . .