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dc.creatorOpačić, Miloš
dc.creatorStević, Zorica D
dc.creatorBaščarević, Vladimir
dc.creatorZivić, Miroslav
dc.creatorSpasić, Mihajlo
dc.creatorSpasojević, Ivan
dc.date.accessioned2022-04-05T15:12:43Z
dc.date.available2022-04-05T15:12:43Z
dc.date.issued2018
dc.identifier.issn1523-0864
dc.identifier.urihttp://rimsi.imsi.bg.ac.rs/handle/123456789/1115
dc.description.abstractThe monitoring of progression in amyotrophic lateral sclerosis (ALS) relies on clinical outcome measures that take months to interpret, such as revised ALS functional rating scale (ALSFRS-R) score, with no approved biomarkers. A number of clinical studies have documented the involvement of oxidative stress in ALS pathology. Pertinent to this, we propose to evaluate oxidation-reduction potential (ORP) of cerebrospinal fluid (CSF) as a potential indicator of ALS progression. The case-control study included 24 patients with neurological non-neurodegenerative disorders (controls) and 82 ALS patients with different degrees of disease (ALSFRS-R score: 21-47). ORP was significantly higher in ALS patients than controls. It was not dependent on age or gender. A strong negative correlation was found between ORP and ALSFRS-R score for all patients and patients with spinal onset. In other words, ORP increased with ALS progression. No correlation was found for the subset of patients with bulbar onset, most likely because of the physical distance between neurodegenerative loci and the site of CSF collection. These results lead to the hypothesis that ORP of CSF has a potential as monitoring biomarker in ALS, particularly in the cohort of patients with spinal onset. Antioxid. Redox Signal. 00, 000-000.en
dc.publisherMary Ann Liebert, Inc, New Rochelle
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173014/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41014/RS//
dc.rightsrestrictedAccess
dc.sourceAntioxidants & Redox Signaling
dc.subjectprogressionen
dc.subjectoxidative stressen
dc.subjectcerebrospinal fluiden
dc.subjectbiomarkeren
dc.subjectamyotrophic lateral sclerosisen
dc.titleCan Oxidation-Reduction Potential of Cerebrospinal Fluid Be a Monitoring Biomarker in Amyotrophic Lateral Sclerosis?en
dc.typearticle
dc.rights.licenseARR
dc.citation.epage1575
dc.citation.issue17
dc.citation.other28(17): 1570-1575
dc.citation.rankM21
dc.citation.spage1570
dc.citation.volume28
dc.identifier.doi10.1089/ars.2017.7433
dc.identifier.pmid29113448
dc.identifier.scopus2-s2.0-85046633968
dc.identifier.wos000417814300001
dc.type.versionpublishedVersion


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