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Comparative assessment of cardiac activity and DNA damage in haemocytes of the Mediterranean mussel Mytilus galloprovincialis in exposure to tributyltin chloride
dc.creator | Martinović, Rajko | |
dc.creator | Kolarević, Stoimir | |
dc.creator | Kracun-Kolarević, Margareta | |
dc.creator | Kostić-Vuković, Jovana | |
dc.creator | Jokanović, Sandra | |
dc.creator | Gačić, Zoran | |
dc.creator | Joksimović, Danijela | |
dc.creator | Durović, Mirko | |
dc.creator | Kljajic, Zoran | |
dc.creator | Vukovic-Gacic, Branka | |
dc.date.accessioned | 2022-04-05T15:05:39Z | |
dc.date.available | 2022-04-05T15:05:39Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1382-6689 | |
dc.identifier.uri | http://rimsi.imsi.bg.ac.rs/handle/123456789/1009 | |
dc.description.abstract | This study gives an insight in sensitivity of heart rate (Hr) of Mytilus galloprovincialis as a physiological biomarker. Impact of tributyltin chloride (TBT-Cl) on Hr was studied in parallel with evaluation of mutagenic, genotoxic and cytotoxic potential of TBT-Cl (10,100 and 1000 mu g/L) within 96 h treatment in static conditions. Mutagenic potential was assessed by SOS/umuC assay while genotoxicity was assessed in haemocytes of M. galloprovincialis by using the comet assay and the micronucleus test. Benzo(a)pyrene (B(a)P) was used as a positive control. Hr variations detected in TBT-Cl treatments can be linked to data obtained in the genotoxicological assays indicating that Hr can be considered and used as a reliable physiological biomarker for detecting the presence of organotin compounds. However despite the observed genotoxic potential of B(a)P, a noteworthy Hr response was not observed which further questions the potential of Hr in the detection of different types of pollutants. | en |
dc.publisher | Elsevier Science Bv, Amsterdam | |
dc.relation | bilateral project Serbia - Slovenia [BI-RS/14-15-013] | |
dc.rights | restrictedAccess | |
dc.source | Environmental Toxicology and Pharmacology | |
dc.subject | Tributyltin | en |
dc.subject | Mytilus galloprovincialis | en |
dc.subject | Heart rate | en |
dc.subject | DNA damage | en |
dc.title | Comparative assessment of cardiac activity and DNA damage in haemocytes of the Mediterranean mussel Mytilus galloprovincialis in exposure to tributyltin chloride | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 174 | |
dc.citation.other | 47: 165-174 | |
dc.citation.rank | M22 | |
dc.citation.spage | 165 | |
dc.citation.volume | 47 | |
dc.identifier.doi | 10.1016/j.etap.2016.09.019 | |
dc.identifier.pmid | 27694055 | |
dc.identifier.scopus | 2-s2.0-84989180801 | |
dc.identifier.wos | 000387936700021 | |
dc.type.version | publishedVersion |