TY  - JOUR
AU  - Kalauzi, Aleksandar
AU  - Spasić, Slađana
AU  - Petrović, Jelena
AU  - Ciric, Jelena
AU  - Šaponjić, Jasna
PY  - 2012
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/550
AB  - This study was aimed to explore the sleep/wake states related cortico-pontine theta carrier frequency phase shift following a systemically induced chemical axotomy of the monoaminergic afferents within a brain of the freely moving rats. Our experiments were performed in 14 adult, male Sprague Dawley rats, chronically implanted for sleep recording. We recorded sleep during baseline condition, following sham injection (saline i.p. 1 ml/kg), and every week for 5 weeks following injection of the systemic neurotoxins (DSP-4 or PCA; 1 ml/kg, i.p.) for chemical axotomy of the locus coeruleus (LC) and dorsal raphe (DR) axon terminals. After sleep/wake states identification, FFT analysis was performed on 5 s epochs. Theta carrier frequency phase shift (Delta Phi) was calculated for each epoch by averaging theta Fourier component phase shifts, and the Delta Phi values were plotted for each rat in control condition and 28 days following the monoaminergic lesions, as a time for permanently established DR or LC chemical axotomy. Calculated group averages have shown that Delta Phi increased between pons and cortex significantly in all sleep/wake states (Wake, NREM and REM) following the monoaminergic lesions, with respect to controls. Monoaminergic lesions established the pontine leading role in the brain theta oscillations during all sleep/wake states.
PB  - General Physiol And Biophysics, Bratislava
T2  - General Physiology and Biophysics
T1  - Cortico-pontine theta carrier frequency phase shift across sleep/wake states following monoaminergic lesion in rat
EP  - 171
IS  - 2
SP  - 163
VL  - 31
DO  - 10.4149/gpb_2012_018
ER  - 

@article{
author = "Kalauzi, Aleksandar and Spasić, Slađana and Petrović, Jelena and Ciric, Jelena and Šaponjić, Jasna",
year = "2012",
abstract = "This study was aimed to explore the sleep/wake states related cortico-pontine theta carrier frequency phase shift following a systemically induced chemical axotomy of the monoaminergic afferents within a brain of the freely moving rats. Our experiments were performed in 14 adult, male Sprague Dawley rats, chronically implanted for sleep recording. We recorded sleep during baseline condition, following sham injection (saline i.p. 1 ml/kg), and every week for 5 weeks following injection of the systemic neurotoxins (DSP-4 or PCA; 1 ml/kg, i.p.) for chemical axotomy of the locus coeruleus (LC) and dorsal raphe (DR) axon terminals. After sleep/wake states identification, FFT analysis was performed on 5 s epochs. Theta carrier frequency phase shift (Delta Phi) was calculated for each epoch by averaging theta Fourier component phase shifts, and the Delta Phi values were plotted for each rat in control condition and 28 days following the monoaminergic lesions, as a time for permanently established DR or LC chemical axotomy. Calculated group averages have shown that Delta Phi increased between pons and cortex significantly in all sleep/wake states (Wake, NREM and REM) following the monoaminergic lesions, with respect to controls. Monoaminergic lesions established the pontine leading role in the brain theta oscillations during all sleep/wake states.",
publisher = "General Physiol And Biophysics, Bratislava",
journal = "General Physiology and Biophysics",
title = "Cortico-pontine theta carrier frequency phase shift across sleep/wake states following monoaminergic lesion in rat",
pages = "171-163",
number = "2",
volume = "31",
doi = "10.4149/gpb_2012_018"
}

Kalauzi, A., Spasić, S., Petrović, J., Ciric, J.,& Šaponjić, J.. (2012). Cortico-pontine theta carrier frequency phase shift across sleep/wake states following monoaminergic lesion in rat. in General Physiology and Biophysics
General Physiol And Biophysics, Bratislava., 31(2), 163-171.
https://doi.org/10.4149/gpb_2012_018

Kalauzi A, Spasić S, Petrović J, Ciric J, Šaponjić J. Cortico-pontine theta carrier frequency phase shift across sleep/wake states following monoaminergic lesion in rat. in General Physiology and Biophysics. 2012;31(2):163-171.
doi:10.4149/gpb_2012_018 .

Kalauzi, Aleksandar, Spasić, Slađana, Petrović, Jelena, Ciric, Jelena, Šaponjić, Jasna, "Cortico-pontine theta carrier frequency phase shift across sleep/wake states following monoaminergic lesion in rat" in General Physiology and Biophysics, 31, no. 2 (2012):163-171,
https://doi.org/10.4149/gpb_2012_018 . .

TY  - JOUR
AU  - Spasić, Slađana
AU  - Kalauzi, Aleksandar
AU  - Kesic, Srdjan
AU  - Obradović, Milica
AU  - Šaponjić, Jasna
PY  - 2011
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/460
AB  - We used spectral analysis and Higuchi fractal dimension (FD) to correlate the EEG spectral characteristics of the sensorimotor cortex, hippocampus, and pons with their corresponding EEG signal complexities in anesthetized rats. We have explored the quantitative relationship between the mean FDs and EEG wide range high frequency (8-50 Hz) activity during ketamine/xylazine versus nembutal anesthesia at surgical plane. Using FD we detected distinct inter-structure complexity pattern and uncovered for the first time that the polygraphically and behaviorally defined anesthetized state at surgical plane as equal during experiment in two anesthetic regimens, is not the same with respect to the degree of neuronal activity (degree of generalized neuronal inhibition achieved) at different brain levels. Using the correlation of certain brain structure EEG spectral characteristics with their corresponding FDs, and the surrogate data modeling, we determined what particular frequency band contributes to EEG complexities in ketamine/xylazine versus nembutal anesthesia. In this study we have shown that the quantitative relationship between higher frequency EEG amplitude and EEG complexity is the best-modeled by surrogate data as a 3rd order polynomial. On the base of our EEG amplitude/EEG complexity relationship model, and the evidenced spectral differences in ketamine versus nembutal anesthesia we have proved that higher amplitudes of sigma, beta, and gamma frequency in ketamine anesthesia yields to higher FDs.
PB  - Academic Press Ltd- Elsevier Science Ltd, London
T2  - Journal of Theoretical Biology
T1  - Surrogate data modeling the relationship between high frequency amplitudes and Higuchi fractal dimension of EEG signals in anesthetized rats
EP  - 166
SP  - 160
VL  - 289
DO  - 10.1016/j.jtbi.2011.08.037
ER  - 

@article{
author = "Spasić, Slađana and Kalauzi, Aleksandar and Kesic, Srdjan and Obradović, Milica and Šaponjić, Jasna",
year = "2011",
abstract = "We used spectral analysis and Higuchi fractal dimension (FD) to correlate the EEG spectral characteristics of the sensorimotor cortex, hippocampus, and pons with their corresponding EEG signal complexities in anesthetized rats. We have explored the quantitative relationship between the mean FDs and EEG wide range high frequency (8-50 Hz) activity during ketamine/xylazine versus nembutal anesthesia at surgical plane. Using FD we detected distinct inter-structure complexity pattern and uncovered for the first time that the polygraphically and behaviorally defined anesthetized state at surgical plane as equal during experiment in two anesthetic regimens, is not the same with respect to the degree of neuronal activity (degree of generalized neuronal inhibition achieved) at different brain levels. Using the correlation of certain brain structure EEG spectral characteristics with their corresponding FDs, and the surrogate data modeling, we determined what particular frequency band contributes to EEG complexities in ketamine/xylazine versus nembutal anesthesia. In this study we have shown that the quantitative relationship between higher frequency EEG amplitude and EEG complexity is the best-modeled by surrogate data as a 3rd order polynomial. On the base of our EEG amplitude/EEG complexity relationship model, and the evidenced spectral differences in ketamine versus nembutal anesthesia we have proved that higher amplitudes of sigma, beta, and gamma frequency in ketamine anesthesia yields to higher FDs.",
publisher = "Academic Press Ltd- Elsevier Science Ltd, London",
journal = "Journal of Theoretical Biology",
title = "Surrogate data modeling the relationship between high frequency amplitudes and Higuchi fractal dimension of EEG signals in anesthetized rats",
pages = "166-160",
volume = "289",
doi = "10.1016/j.jtbi.2011.08.037"
}

Spasić, S., Kalauzi, A., Kesic, S., Obradović, M.,& Šaponjić, J.. (2011). Surrogate data modeling the relationship between high frequency amplitudes and Higuchi fractal dimension of EEG signals in anesthetized rats. in Journal of Theoretical Biology
Academic Press Ltd- Elsevier Science Ltd, London., 289, 160-166.
https://doi.org/10.1016/j.jtbi.2011.08.037

Spasić S, Kalauzi A, Kesic S, Obradović M, Šaponjić J. Surrogate data modeling the relationship between high frequency amplitudes and Higuchi fractal dimension of EEG signals in anesthetized rats. in Journal of Theoretical Biology. 2011;289:160-166.
doi:10.1016/j.jtbi.2011.08.037 .

Spasić, Slađana, Kalauzi, Aleksandar, Kesic, Srdjan, Obradović, Milica, Šaponjić, Jasna, "Surrogate data modeling the relationship between high frequency amplitudes and Higuchi fractal dimension of EEG signals in anesthetized rats" in Journal of Theoretical Biology, 289 (2011):160-166,
https://doi.org/10.1016/j.jtbi.2011.08.037 . .