TY  - JOUR
AU  - Žižić, Milan
AU  - Atlagić, Kristina
AU  - Karaman, Maja
AU  - Živić, Miroslav
AU  - Stanić, Marina
AU  - Maksimović, Vuk
AU  - Zakrzewska, Joanna
PY  - 2024
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/3165
AB  - BACKGROUND
Fungi absorb and solubilize a broad spectrum of heavy metals such as vanadium (V), which makes them a main route of its entry into the biosphere. V as vanadate (V5+) is a potential medical agent due to its many metabolic actions such as interaction with phosphates in the cell, and especially its insulin-mimetic activity. Antidiabetic activity of V-enriched fungi has been studied in recent years, but the biological and chemical bases of vanadium action and status in fungi in general are poorly understood, with almost no information on edible fungi. 
METHODS
This manuscript gives a deeper insight into the interaction of V5+ with Coprinellus truncorum, an edible autochthonous species widely distributed in Europe and North America. Vanadium uptake and accumulation as V5+ was studied by 51V NMR, while the reducing abilities of the mycelium were determined by EPR. 31P NMR was used to determine its effects on the metabolism of phosphate compounds, with particular focus on phosphate sugars identified using HPLC.
RESULTS
Vanadate enters the mycelium in monomeric form and shows no immediate detrimental effects on intracellular pH or polyphosphate (PPc) levels, even when applied at physiologically high concentrations (20 mM Na3VO4). Once absorbed, it is partially reduced to less toxic vanadyl (V4+) with notable unreduced portion, which leads to a large increase in phosphorylated sugar levels, especially glucose-1-phosphate (G1P) and fructose-6-phosphate (F6P).
CONCLUSIONS
Preservation of pH and especially PPc reflects maintenance of the energy status of the mycelium, i.e., its tolerance to high V5+ concentrations. Rise in G1P and F6P levels implies that the main targets of V5+ are most likely phosphoglucomutase and phosphoglucokinase(s), enzymes involved in early stages of G6P transformation in glycolysis and glycogen metabolism. This study recommends C. truncorum for further investigation as a potential antidiabetic agent.
PB  - Elsevier Gmbh, Munich
T2  - Journal of Trace Elements in Biology and Medicine
T1  - Uptake of vanadium and its intracellular metabolism by Coprinellus truncorum mycelial biomass
EP  - 127386
SP  - 127381
VL  - 83
DO  - 10.1016/j.jtemb.2024.127381
ER  - 

@article{
author = "Žižić, Milan and Atlagić, Kristina and Karaman, Maja and Živić, Miroslav and Stanić, Marina and Maksimović, Vuk and Zakrzewska, Joanna",
year = "2024",
abstract = "BACKGROUND
Fungi absorb and solubilize a broad spectrum of heavy metals such as vanadium (V), which makes them a main route of its entry into the biosphere. V as vanadate (V5+) is a potential medical agent due to its many metabolic actions such as interaction with phosphates in the cell, and especially its insulin-mimetic activity. Antidiabetic activity of V-enriched fungi has been studied in recent years, but the biological and chemical bases of vanadium action and status in fungi in general are poorly understood, with almost no information on edible fungi. 
METHODS
This manuscript gives a deeper insight into the interaction of V5+ with Coprinellus truncorum, an edible autochthonous species widely distributed in Europe and North America. Vanadium uptake and accumulation as V5+ was studied by 51V NMR, while the reducing abilities of the mycelium were determined by EPR. 31P NMR was used to determine its effects on the metabolism of phosphate compounds, with particular focus on phosphate sugars identified using HPLC.
RESULTS
Vanadate enters the mycelium in monomeric form and shows no immediate detrimental effects on intracellular pH or polyphosphate (PPc) levels, even when applied at physiologically high concentrations (20 mM Na3VO4). Once absorbed, it is partially reduced to less toxic vanadyl (V4+) with notable unreduced portion, which leads to a large increase in phosphorylated sugar levels, especially glucose-1-phosphate (G1P) and fructose-6-phosphate (F6P).
CONCLUSIONS
Preservation of pH and especially PPc reflects maintenance of the energy status of the mycelium, i.e., its tolerance to high V5+ concentrations. Rise in G1P and F6P levels implies that the main targets of V5+ are most likely phosphoglucomutase and phosphoglucokinase(s), enzymes involved in early stages of G6P transformation in glycolysis and glycogen metabolism. This study recommends C. truncorum for further investigation as a potential antidiabetic agent.",
publisher = "Elsevier Gmbh, Munich",
journal = "Journal of Trace Elements in Biology and Medicine",
title = "Uptake of vanadium and its intracellular metabolism by Coprinellus truncorum mycelial biomass",
pages = "127386-127381",
volume = "83",
doi = "10.1016/j.jtemb.2024.127381"
}

Žižić, M., Atlagić, K., Karaman, M., Živić, M., Stanić, M., Maksimović, V.,& Zakrzewska, J.. (2024). Uptake of vanadium and its intracellular metabolism by Coprinellus truncorum mycelial biomass. in Journal of Trace Elements in Biology and Medicine
Elsevier Gmbh, Munich., 83, 127381-127386.
https://doi.org/10.1016/j.jtemb.2024.127381

Žižić M, Atlagić K, Karaman M, Živić M, Stanić M, Maksimović V, Zakrzewska J. Uptake of vanadium and its intracellular metabolism by Coprinellus truncorum mycelial biomass. in Journal of Trace Elements in Biology and Medicine. 2024;83:127381-127386.
doi:10.1016/j.jtemb.2024.127381 .

Žižić, Milan, Atlagić, Kristina, Karaman, Maja, Živić, Miroslav, Stanić, Marina, Maksimović, Vuk, Zakrzewska, Joanna, "Uptake of vanadium and its intracellular metabolism by Coprinellus truncorum mycelial biomass" in Journal of Trace Elements in Biology and Medicine, 83 (2024):127381-127386,
https://doi.org/10.1016/j.jtemb.2024.127381 . .

TY  - JOUR
AU  - Armaković,Sanja J.
AU  - Jovanoski Kostić,Aleksandra
AU  - Bilić,Andrijana
AU  - Savanović,Maria M.
AU  - Tomić,Nataša
AU  - Kremenović,Aleksandar
AU  - Šćepanović,Maja
AU  - Grujić-Brojčin,Mirjana
AU  - Ćirković, Jovana
AU  - Armaković,Stevan
PY  - 2023
AB  - Due to the inability of conventional wastewater treatment procedures to remove organic
pharmaceutical pollutants, active pharmaceutical components remain in wastewater and even reach
tap water. In terms of pharmaceutical pollutants, the scientific community focuses on  -blockers due
to their extensive (over)usage and moderately high solubility. In this study, the photocatalytic activity
of V2O5 was investigated through the degradation of nadolol (NAD), pindolol (PIN), metoprolol
(MET), and their mixture under ultraviolet (UV) irradiation in water. For the preparation of V2O5,
facile hydrothermal synthesis was used. The structural, morphological, and surface properties
and purity of synthesized V2O5 powder were investigated by scanning electron microscopy (SEM),
X-ray, and Raman spectroscopy. SEM micrographs showed hexagonal-shaped platelets with welldefined
morphology of materials with diameters in the range of 10–65 μm and thickness of around
a few microns. X-ray diffraction identified only one crystalline phase in the sample. The Raman
scattering measurements taken on the catalyst confirmed the result of XRPD. Degradation kinetics
were monitored by ultra-fast liquid chromatography with diode array detection. The results showed
that in individual solutions, photocatalytic degradation of MET and NAD was relatively insignificant
(<10%). However, in the PIN case, the degradation was significant (64%). In the mixture, the
photodegradation efficiency of MET and NAD slightly increased (15% and 13%). Conversely, it
reduced the PIN to the still satisfactory value of 40%. Computational analysis based on molecular and
periodic density functional theory calculations was used to complement our experimental findings.
Calculations of the average local ionization energy indicate that the PIN is the most reactive of all
three considered molecules in terms of removing an electron from it.
PB  - MDPI
T2  - Molecules
T1  - Photocatalytic Activity of the V2O5 Catalyst toward Selected
Pharmaceuticals and Their Mixture: Influence of the Molecular
Structure on the Efficiency of the Process
EP  - 18
SP  - 1
VL  - 28
DO  - 10.3390/molecules28020655
ER  - 

@article{
author = "Armaković,Sanja J. and Jovanoski Kostić,Aleksandra and Bilić,Andrijana and Savanović,Maria M. and Tomić,Nataša and Kremenović,Aleksandar and Šćepanović,Maja and Grujić-Brojčin,Mirjana and Ćirković, Jovana and Armaković,Stevan",
year = "2023",
abstract = "Due to the inability of conventional wastewater treatment procedures to remove organic
pharmaceutical pollutants, active pharmaceutical components remain in wastewater and even reach
tap water. In terms of pharmaceutical pollutants, the scientific community focuses on  -blockers due
to their extensive (over)usage and moderately high solubility. In this study, the photocatalytic activity
of V2O5 was investigated through the degradation of nadolol (NAD), pindolol (PIN), metoprolol
(MET), and their mixture under ultraviolet (UV) irradiation in water. For the preparation of V2O5,
facile hydrothermal synthesis was used. The structural, morphological, and surface properties
and purity of synthesized V2O5 powder were investigated by scanning electron microscopy (SEM),
X-ray, and Raman spectroscopy. SEM micrographs showed hexagonal-shaped platelets with welldefined
morphology of materials with diameters in the range of 10–65 μm and thickness of around
a few microns. X-ray diffraction identified only one crystalline phase in the sample. The Raman
scattering measurements taken on the catalyst confirmed the result of XRPD. Degradation kinetics
were monitored by ultra-fast liquid chromatography with diode array detection. The results showed
that in individual solutions, photocatalytic degradation of MET and NAD was relatively insignificant
(<10%). However, in the PIN case, the degradation was significant (64%). In the mixture, the
photodegradation efficiency of MET and NAD slightly increased (15% and 13%). Conversely, it
reduced the PIN to the still satisfactory value of 40%. Computational analysis based on molecular and
periodic density functional theory calculations was used to complement our experimental findings.
Calculations of the average local ionization energy indicate that the PIN is the most reactive of all
three considered molecules in terms of removing an electron from it.",
publisher = "MDPI",
journal = "Molecules",
title = "Photocatalytic Activity of the V2O5 Catalyst toward Selected
Pharmaceuticals and Their Mixture: Influence of the Molecular
Structure on the Efficiency of the Process",
pages = "18-1",
volume = "28",
doi = "10.3390/molecules28020655"
}

Armaković, S. J., Jovanoski Kostić, A., Bilić, A., Savanović, M. M., Tomić, N., Kremenović, A., Šćepanović, M., Grujić-Brojčin, M., Ćirković, J.,& Armaković, S.. (2023). Photocatalytic Activity of the V2O5 Catalyst toward Selected
Pharmaceuticals and Their Mixture: Influence of the Molecular
Structure on the Efficiency of the Process. in Molecules
MDPI., 28, 1-18.
https://doi.org/10.3390/molecules28020655

Armaković SJ, Jovanoski Kostić A, Bilić A, Savanović MM, Tomić N, Kremenović A, Šćepanović M, Grujić-Brojčin M, Ćirković J, Armaković S. Photocatalytic Activity of the V2O5 Catalyst toward Selected
Pharmaceuticals and Their Mixture: Influence of the Molecular
Structure on the Efficiency of the Process. in Molecules. 2023;28:1-18.
doi:10.3390/molecules28020655 .

Armaković,Sanja J., Jovanoski Kostić,Aleksandra, Bilić,Andrijana, Savanović,Maria M., Tomić,Nataša, Kremenović,Aleksandar, Šćepanović,Maja, Grujić-Brojčin,Mirjana, Ćirković, Jovana, Armaković,Stevan, "Photocatalytic Activity of the V2O5 Catalyst toward Selected
Pharmaceuticals and Their Mixture: Influence of the Molecular
Structure on the Efficiency of the Process" in Molecules, 28 (2023):1-18,
https://doi.org/10.3390/molecules28020655 . .

TY  - JOUR
AU  - Ristic, Predrag
AU  - Filipović, Nenad
AU  - Blagojević, Vladimir
AU  - Ćirković, Jovana
AU  - Hollo, Berta Barta
AU  - Dokic, Veljko R.
AU  - Donnard, Morgan
AU  - Gulea, Mihaela
AU  - Marjanović, Ivana
AU  - Klisuric, Olivera R.
AU  - Todorović, Tamara R.
PY  - 2021
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1461
AB  - Four silver-based coordination polymers, {[Ag(L1)(2)]NO3}(infinity) (1), {[Ag(L1)(2)]ClO4}(infinity) (2), {[Ag(L2)(2)]NO3 center dot H2O}(infinity) (3) and {[Ag(L2)(2)]ClO4}(infinity) (4), were synthesized using the thiomorpholine-4-carbonitrile (L1) and piperazine-1,4-dicarbonitrile (L2) ligands. Compounds 1 and 2 are two-dimensional, while 3 and 4 are three-dimensional. L1 and L2 are 1,4-bis-monodentate ligands in all compounds, while Ag(i) ions are four-coordinated in a slightly distorted tetrahedral geometry. Topological analysis in standard representations suggests that underlying nets in 1 and 2 have an sql topology, while 3 and 4 exhibit a dia topology. Thermal analysis shows that 3 loses crystalline water at room temperature, while other compounds show good thermal stability. All compounds show good photocatalytic activity for photocatalytic degradation of the mordant blue 9 dye, with reaction rates in the range 0.029 to 0.061 min(-1). The best result was obtained for compound 4, which can be correlated to its largest lattice volume.
PB  - Royal Soc Chemistry, Cambridge
T2  - Crystengcomm
T1  - 2D and 3D silver-based coordination polymers with thiomorpholine-4-carbonitrile and piperazine-1,4-dicarbonitrile: structure, intermolecular interactions, photocatalysis, and thermal behavior
EP  - 4815
IS  - 27
SP  - 4799
VL  - 23
DO  - 10.1039/d1ce00394a
ER  - 

@article{
author = "Ristic, Predrag and Filipović, Nenad and Blagojević, Vladimir and Ćirković, Jovana and Hollo, Berta Barta and Dokic, Veljko R. and Donnard, Morgan and Gulea, Mihaela and Marjanović, Ivana and Klisuric, Olivera R. and Todorović, Tamara R.",
year = "2021",
abstract = "Four silver-based coordination polymers, {[Ag(L1)(2)]NO3}(infinity) (1), {[Ag(L1)(2)]ClO4}(infinity) (2), {[Ag(L2)(2)]NO3 center dot H2O}(infinity) (3) and {[Ag(L2)(2)]ClO4}(infinity) (4), were synthesized using the thiomorpholine-4-carbonitrile (L1) and piperazine-1,4-dicarbonitrile (L2) ligands. Compounds 1 and 2 are two-dimensional, while 3 and 4 are three-dimensional. L1 and L2 are 1,4-bis-monodentate ligands in all compounds, while Ag(i) ions are four-coordinated in a slightly distorted tetrahedral geometry. Topological analysis in standard representations suggests that underlying nets in 1 and 2 have an sql topology, while 3 and 4 exhibit a dia topology. Thermal analysis shows that 3 loses crystalline water at room temperature, while other compounds show good thermal stability. All compounds show good photocatalytic activity for photocatalytic degradation of the mordant blue 9 dye, with reaction rates in the range 0.029 to 0.061 min(-1). The best result was obtained for compound 4, which can be correlated to its largest lattice volume.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Crystengcomm",
title = "2D and 3D silver-based coordination polymers with thiomorpholine-4-carbonitrile and piperazine-1,4-dicarbonitrile: structure, intermolecular interactions, photocatalysis, and thermal behavior",
pages = "4815-4799",
number = "27",
volume = "23",
doi = "10.1039/d1ce00394a"
}

Ristic, P., Filipović, N., Blagojević, V., Ćirković, J., Hollo, B. B., Dokic, V. R., Donnard, M., Gulea, M., Marjanović, I., Klisuric, O. R.,& Todorović, T. R.. (2021). 2D and 3D silver-based coordination polymers with thiomorpholine-4-carbonitrile and piperazine-1,4-dicarbonitrile: structure, intermolecular interactions, photocatalysis, and thermal behavior. in Crystengcomm
Royal Soc Chemistry, Cambridge., 23(27), 4799-4815.
https://doi.org/10.1039/d1ce00394a

Ristic P, Filipović N, Blagojević V, Ćirković J, Hollo BB, Dokic VR, Donnard M, Gulea M, Marjanović I, Klisuric OR, Todorović TR. 2D and 3D silver-based coordination polymers with thiomorpholine-4-carbonitrile and piperazine-1,4-dicarbonitrile: structure, intermolecular interactions, photocatalysis, and thermal behavior. in Crystengcomm. 2021;23(27):4799-4815.
doi:10.1039/d1ce00394a .

Ristic, Predrag, Filipović, Nenad, Blagojević, Vladimir, Ćirković, Jovana, Hollo, Berta Barta, Dokic, Veljko R., Donnard, Morgan, Gulea, Mihaela, Marjanović, Ivana, Klisuric, Olivera R., Todorović, Tamara R., "2D and 3D silver-based coordination polymers with thiomorpholine-4-carbonitrile and piperazine-1,4-dicarbonitrile: structure, intermolecular interactions, photocatalysis, and thermal behavior" in Crystengcomm, 23, no. 27 (2021):4799-4815,
https://doi.org/10.1039/d1ce00394a . .