TY  - JOUR
AU  - Martać, Ljiljana
AU  - Kesić, Srđan Ž.
AU  - Ćulić, Milka
AU  - Grbić, Gordana
AU  - Spasić, Slađana
AU  - Sekulić, Slobodan
AU  - Lalošević, Dušan
PY  - 2006
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/2877
AB  - The aim of our study was to investigate the electrophysiological effects of aluminium neurotoxicity. This animal model of neurodegenerative dementia was induced by chronic treatment of Wistarrats with aluminum chloride for 4 weeks - 2mg Al/kg, i.p, per day. Electrophysiological recordings of left and right somatosensory cortical areas of animals treated by aluminium and the control rats were done under Nembutal anesthesia. Analog to the digital one conversion of the recorded signals was performed at the sampling rate of 256 Hz. Spectral analysis of electrocortical activity during sequences of 120 s (divided in epochs of 8s) was obtained by Fast Fourier Transformation while fractal dimension (FD) of these signals was calculated by Higuchi's algorithm. The relative power spectra of cerebral activity were increased in delta frequency range and decreased in (8.1-32.0 Hz) range in aluminium treated animals compared to the controls. The average fractal dimension of electrocortical activity in aluminium treated animals was lower - 1.290 than the average fractal dimension of electrocortical activity in the control rats - 1.377. Spectral and fractal characteristics of brain activity could bean electrophysiological sign of developing neurodegenerative process similar to the Alzheimer's dementia.
T2  - Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica
T1  - Efekat neurotoksičnosti aluminijuma na elektrokortikalnu aktivnost mozga pacova
T1  - Effect of aluminium neurotoxicity on the rat brain electrocortical activity
EP  - 225
IS  - 3
SP  - 219
VL  - 42
UR  - https://hdl.handle.net/21.15107/rcub_rimsi_2877
ER  - 

@article{
author = "Martać, Ljiljana and Kesić, Srđan Ž. and Ćulić, Milka and Grbić, Gordana and Spasić, Slađana and Sekulić, Slobodan and Lalošević, Dušan",
year = "2006",
abstract = "The aim of our study was to investigate the electrophysiological effects of aluminium neurotoxicity. This animal model of neurodegenerative dementia was induced by chronic treatment of Wistarrats with aluminum chloride for 4 weeks - 2mg Al/kg, i.p, per day. Electrophysiological recordings of left and right somatosensory cortical areas of animals treated by aluminium and the control rats were done under Nembutal anesthesia. Analog to the digital one conversion of the recorded signals was performed at the sampling rate of 256 Hz. Spectral analysis of electrocortical activity during sequences of 120 s (divided in epochs of 8s) was obtained by Fast Fourier Transformation while fractal dimension (FD) of these signals was calculated by Higuchi's algorithm. The relative power spectra of cerebral activity were increased in delta frequency range and decreased in (8.1-32.0 Hz) range in aluminium treated animals compared to the controls. The average fractal dimension of electrocortical activity in aluminium treated animals was lower - 1.290 than the average fractal dimension of electrocortical activity in the control rats - 1.377. Spectral and fractal characteristics of brain activity could bean electrophysiological sign of developing neurodegenerative process similar to the Alzheimer's dementia.",
journal = "Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica",
title = "Efekat neurotoksičnosti aluminijuma na elektrokortikalnu aktivnost mozga pacova, Effect of aluminium neurotoxicity on the rat brain electrocortical activity",
pages = "225-219",
number = "3",
volume = "42",
url = "https://hdl.handle.net/21.15107/rcub_rimsi_2877"
}

Martać, L., Kesić, S. Ž., Ćulić, M., Grbić, G., Spasić, S., Sekulić, S.,& Lalošević, D.. (2006). Efekat neurotoksičnosti aluminijuma na elektrokortikalnu aktivnost mozga pacova. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42(3), 219-225.
https://hdl.handle.net/21.15107/rcub_rimsi_2877

Martać L, Kesić SŽ, Ćulić M, Grbić G, Spasić S, Sekulić S, Lalošević D. Efekat neurotoksičnosti aluminijuma na elektrokortikalnu aktivnost mozga pacova. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica. 2006;42(3):219-225.
https://hdl.handle.net/21.15107/rcub_rimsi_2877 .

Martać, Ljiljana, Kesić, Srđan Ž., Ćulić, Milka, Grbić, Gordana, Spasić, Slađana, Sekulić, Slobodan, Lalošević, Dušan, "Efekat neurotoksičnosti aluminijuma na elektrokortikalnu aktivnost mozga pacova" in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42, no. 3 (2006):219-225,
https://hdl.handle.net/21.15107/rcub_rimsi_2877 .