TY  - CONF
AU  - Milenković, Ivana
AU  - Algarra, Manuel
AU  - Spasić, Slađana
AU  - Mitrović, Aleksandra Lj.
AU  - Beškoski, Vladimir
AU  - Radotić, Ksenija
PY  - 2018
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1824
AB  - CeO2 nanoparticles (nCeO2) are popular because of unique redox property-transition between oxidation states (Ce3+ and Ce4+). Their tendency for agglomeration has led many researchers to coat nCeO2 with different polymers, but little is known about the impact of coated nanoparticles on plant metabolism. Increased nCeO2 application enhance risk for the environment due to their accumulation in soil, air and water. Metal toxicity cause abiotic stress and lead to overproduction of reactive oxygen species (ROS), damaging important biological molecules in plants.
In this research, we performed a three week treatment of seedlings of two agricultural plants in hydroponics with 200 mg/L uncoated and glucose-, levan- and pullulan coated nCeO2 (G-CeO2, L-CeO2 and P-CeO2). Our aim was to study the effect of nanoparticles coating on Ce uptake, and on changes in total antioxidant activity (TAA), the indicator of oxidative stress, in monocotyledonous and dicotyledonous crop species. Concentration of Ce in shoots of treated seedlings was determined using ICP-OES.
The uptake of Ce differed in the treated plant species. Coating of nCeO2 increased Ce uptake in pea, but decreased in wheat. However, Ce content was 20 fold higher in weat compared to pea plants, regardless of nanoparticles coating. Extremly high Ce content measured in wheat, coincided with the decrease in TAA. On the other hand, low Ce content measured in pea, coinceded with no changes in TAA. 
Presented results sugest the difference in nCeO2 uptake and its physiological effects between monocotyledonous and dicotyledonous plant species, but further research is necessary.
PB  - Serbian Plant Physiology Society
PB  - Institute for Biological Research “Siniša Stanković”, University of Belgrade
PB  - Faculty of Biology, University of Belgrade
C3  - 3rd International Conference of Plant Biology
T1  - Total antioxidant activity in wheat and pea seedlings treated with uncoated and polysaccharide coated CeO2 nanoparticles
SP  - 65
UR  - https://hdl.handle.net/21.15107/rcub_rimsi_1824
ER  - 

@conference{
author = "Milenković, Ivana and Algarra, Manuel and Spasić, Slađana and Mitrović, Aleksandra Lj. and Beškoski, Vladimir and Radotić, Ksenija",
year = "2018",
abstract = "CeO2 nanoparticles (nCeO2) are popular because of unique redox property-transition between oxidation states (Ce3+ and Ce4+). Their tendency for agglomeration has led many researchers to coat nCeO2 with different polymers, but little is known about the impact of coated nanoparticles on plant metabolism. Increased nCeO2 application enhance risk for the environment due to their accumulation in soil, air and water. Metal toxicity cause abiotic stress and lead to overproduction of reactive oxygen species (ROS), damaging important biological molecules in plants.
In this research, we performed a three week treatment of seedlings of two agricultural plants in hydroponics with 200 mg/L uncoated and glucose-, levan- and pullulan coated nCeO2 (G-CeO2, L-CeO2 and P-CeO2). Our aim was to study the effect of nanoparticles coating on Ce uptake, and on changes in total antioxidant activity (TAA), the indicator of oxidative stress, in monocotyledonous and dicotyledonous crop species. Concentration of Ce in shoots of treated seedlings was determined using ICP-OES.
The uptake of Ce differed in the treated plant species. Coating of nCeO2 increased Ce uptake in pea, but decreased in wheat. However, Ce content was 20 fold higher in weat compared to pea plants, regardless of nanoparticles coating. Extremly high Ce content measured in wheat, coincided with the decrease in TAA. On the other hand, low Ce content measured in pea, coinceded with no changes in TAA. 
Presented results sugest the difference in nCeO2 uptake and its physiological effects between monocotyledonous and dicotyledonous plant species, but further research is necessary.",
publisher = "Serbian Plant Physiology Society, Institute for Biological Research “Siniša Stanković”, University of Belgrade, Faculty of Biology, University of Belgrade",
journal = "3rd International Conference of Plant Biology",
title = "Total antioxidant activity in wheat and pea seedlings treated with uncoated and polysaccharide coated CeO2 nanoparticles",
pages = "65",
url = "https://hdl.handle.net/21.15107/rcub_rimsi_1824"
}

Milenković, I., Algarra, M., Spasić, S., Mitrović, A. Lj., Beškoski, V.,& Radotić, K.. (2018). Total antioxidant activity in wheat and pea seedlings treated with uncoated and polysaccharide coated CeO2 nanoparticles. in 3rd International Conference of Plant Biology
Serbian Plant Physiology Society., 65.
https://hdl.handle.net/21.15107/rcub_rimsi_1824

Milenković I, Algarra M, Spasić S, Mitrović AL, Beškoski V, Radotić K. Total antioxidant activity in wheat and pea seedlings treated with uncoated and polysaccharide coated CeO2 nanoparticles. in 3rd International Conference of Plant Biology. 2018;:65.
https://hdl.handle.net/21.15107/rcub_rimsi_1824 .

Milenković, Ivana, Algarra, Manuel, Spasić, Slađana, Mitrović, Aleksandra Lj., Beškoski, Vladimir, Radotić, Ksenija, "Total antioxidant activity in wheat and pea seedlings treated with uncoated and polysaccharide coated CeO2 nanoparticles" in 3rd International Conference of Plant Biology (2018):65,
https://hdl.handle.net/21.15107/rcub_rimsi_1824 .

TY  - CONF
AU  - Milenković, Ivana
AU  - Radotić, Ksenija
AU  - Matović, Branko
PY  - 2015
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1826
AB  - CeO2 (nanoceria) is the most important rare-earth oxide and potent free radical scavenger, due to coexistence of Ce3+ and Ce4+ ions and formation of oxygen vacancies on its surface. These nanoparticles can collect reactive oxygen species (ROS) and protect healthy cells from oxidative stress, but they also show cytotoxicity. This dual behavior of nanoceria represents a great pharmacological potential, such as improving the treatment of cancers, drug delivery and catalysis. We established the method for synthesizing these nanoparticles, which was particularly challenging because of their low solubility. To facilitate nanoparticle’s entry into the cells, we further coated these nanoparticles with the addition of carbohydrate (glucose, levan or pullulan) in the reaction mixture during and after the synthesis of nanoceria. We investigated by which of two applied methods of synthesis gave more soluble ceria nanoparticles.
PB  - Scientific association for development and affirmation of new technologies
C3  - 2nd International Conference ’’Modern methods of testing and evaluation in science’’
T1  - The methods for nanoceria’s coating in order to improve its solubility
SP  - 208
UR  - https://hdl.handle.net/21.15107/rcub_rimsi_1826
ER  - 

@conference{
author = "Milenković, Ivana and Radotić, Ksenija and Matović, Branko",
year = "2015",
abstract = "CeO2 (nanoceria) is the most important rare-earth oxide and potent free radical scavenger, due to coexistence of Ce3+ and Ce4+ ions and formation of oxygen vacancies on its surface. These nanoparticles can collect reactive oxygen species (ROS) and protect healthy cells from oxidative stress, but they also show cytotoxicity. This dual behavior of nanoceria represents a great pharmacological potential, such as improving the treatment of cancers, drug delivery and catalysis. We established the method for synthesizing these nanoparticles, which was particularly challenging because of their low solubility. To facilitate nanoparticle’s entry into the cells, we further coated these nanoparticles with the addition of carbohydrate (glucose, levan or pullulan) in the reaction mixture during and after the synthesis of nanoceria. We investigated by which of two applied methods of synthesis gave more soluble ceria nanoparticles.",
publisher = "Scientific association for development and affirmation of new technologies",
journal = "2nd International Conference ’’Modern methods of testing and evaluation in science’’",
title = "The methods for nanoceria’s coating in order to improve its solubility",
pages = "208",
url = "https://hdl.handle.net/21.15107/rcub_rimsi_1826"
}

Milenković, I., Radotić, K.,& Matović, B.. (2015). The methods for nanoceria’s coating in order to improve its solubility. in 2nd International Conference ’’Modern methods of testing and evaluation in science’’
Scientific association for development and affirmation of new technologies., 208.
https://hdl.handle.net/21.15107/rcub_rimsi_1826

Milenković I, Radotić K, Matović B. The methods for nanoceria’s coating in order to improve its solubility. in 2nd International Conference ’’Modern methods of testing and evaluation in science’’. 2015;:208.
https://hdl.handle.net/21.15107/rcub_rimsi_1826 .

Milenković, Ivana, Radotić, Ksenija, Matović, Branko, "The methods for nanoceria’s coating in order to improve its solubility" in 2nd International Conference ’’Modern methods of testing and evaluation in science’’ (2015):208,
https://hdl.handle.net/21.15107/rcub_rimsi_1826 .

TY  - CONF
AU  - Milenković, Ivana
AU  - Radotić, Ksenija
AU  - Matović, Branko
PY  - 2015
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1841
AB  - CeO2 (nanoceria) is the most important rare-earth oxide, which application is rapidly emerging. These nanoparticles are potent free radical scavengers, due to coexistence of Ce3+ and Ce4+ ions and formation of oxygen vacancies on their surface. These ions are promising candidates for improving the treatment of cancers, drug delivery and catalysis. First, they collect reactive oxygen species (ROS) and protect healthy cells from oxidative stress. Also, they show cytotoxicity, which can be manipulated for treatment of cancer cells by inducing targeted cell death with minimal toxicity to surrounding healthy cells. This dual behavior of nanoceria presents a great pharmacological potential. We established the method for synthesizing these nanoparticles. This was particularly challenging because of their low solubility. We further coated these nanoparticles with glucose to facilitate entry into the cells. Untill now, anticancer properties of nanoceria have been poorly characterized. Hence, the aim of this work was to investigate the cytotoxic effect of nanoceria in several cancer cell lines. Nanoceria can be beneficial for the improvement of cancer treatments and a promising candidate for further medical aplication.
PB  - International Max Planck Research School for Molecular Biology in Gottingen
C3  - 12th International PhD Student Symposium Horizons in Molecular Biology
T1  - Anticancer properties of nanoceria
SP  - 101
UR  - https://hdl.handle.net/21.15107/rcub_rimsi_1841
ER  - 

@conference{
author = "Milenković, Ivana and Radotić, Ksenija and Matović, Branko",
year = "2015",
abstract = "CeO2 (nanoceria) is the most important rare-earth oxide, which application is rapidly emerging. These nanoparticles are potent free radical scavengers, due to coexistence of Ce3+ and Ce4+ ions and formation of oxygen vacancies on their surface. These ions are promising candidates for improving the treatment of cancers, drug delivery and catalysis. First, they collect reactive oxygen species (ROS) and protect healthy cells from oxidative stress. Also, they show cytotoxicity, which can be manipulated for treatment of cancer cells by inducing targeted cell death with minimal toxicity to surrounding healthy cells. This dual behavior of nanoceria presents a great pharmacological potential. We established the method for synthesizing these nanoparticles. This was particularly challenging because of their low solubility. We further coated these nanoparticles with glucose to facilitate entry into the cells. Untill now, anticancer properties of nanoceria have been poorly characterized. Hence, the aim of this work was to investigate the cytotoxic effect of nanoceria in several cancer cell lines. Nanoceria can be beneficial for the improvement of cancer treatments and a promising candidate for further medical aplication.",
publisher = "International Max Planck Research School for Molecular Biology in Gottingen",
journal = "12th International PhD Student Symposium Horizons in Molecular Biology",
title = "Anticancer properties of nanoceria",
pages = "101",
url = "https://hdl.handle.net/21.15107/rcub_rimsi_1841"
}

Milenković, I., Radotić, K.,& Matović, B.. (2015). Anticancer properties of nanoceria. in 12th International PhD Student Symposium Horizons in Molecular Biology
International Max Planck Research School for Molecular Biology in Gottingen., 101.
https://hdl.handle.net/21.15107/rcub_rimsi_1841

Milenković I, Radotić K, Matović B. Anticancer properties of nanoceria. in 12th International PhD Student Symposium Horizons in Molecular Biology. 2015;:101.
https://hdl.handle.net/21.15107/rcub_rimsi_1841 .

Milenković, Ivana, Radotić, Ksenija, Matović, Branko, "Anticancer properties of nanoceria" in 12th International PhD Student Symposium Horizons in Molecular Biology (2015):101,
https://hdl.handle.net/21.15107/rcub_rimsi_1841 .