TY  - JOUR
AU  - Antonijević, Marko
AU  - Avdović, Edina
AU  - Simijonović, Dušica
AU  - Milanović, Žiko
AU  - Žižić, Milan
AU  - Marković, Zoran
PY  - 2024
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/3163
AB  - Pharmaceutical and industrial utilization of synthetic chemicals has an immerse impact
on the environment. In that sense, novel chemicals with potential for industrial
application should be investigated for their behavior in reactions with hydroxyl radical,
simulating AOPs (Advanced Oxidation Processes). AOPs are known for being highly
effective in wastewater management and natural water remediation. In this paper,
exhaustive research on the radical scavenging activity of a newly synthesized
coumarin derivative (4HCBH), as a representative of the series of coumarin-
benzohydrazides with high antioxidative potential was conducted. This study took into
consideration the pH value range significant for practically all living organisms (pH=7.0-
8.5). According to the experimentally obtained results, the 4HCBH showed an increase
in radical scavenging activity, following the slight increase in pH values, which
suggested that the formation of anionic form of 4HCBH is responsible for its antiradical
activity. Further investigations led to the postulation of a novel mechanistic approach
called Sequential Proton Loss Electron Transfer – Radical-Radical Coupling (SPLET-
RRC), in which, by a series of steps, a new, stable compound was formed.
Furthermore, it was demonstrated that the product generated through SPLET-RRC
showed lower toxicity than the parent molecule.
PB  - Elsevier
T2  - Science of the Total Environment
T1  - Investigation of Novel Radical Scavenging Mechanisms in the Alkaline Environment: Green, Sustainable and Environmentally Friendly Antioxidative Agent(s)
EP  - 160319
SP  - 169307
VL  - 912
DO  - 10.1016/j.scitotenv.2023.169307
ER  - 

@article{
author = "Antonijević, Marko and Avdović, Edina and Simijonović, Dušica and Milanović, Žiko and Žižić, Milan and Marković, Zoran",
year = "2024",
abstract = "Pharmaceutical and industrial utilization of synthetic chemicals has an immerse impact
on the environment. In that sense, novel chemicals with potential for industrial
application should be investigated for their behavior in reactions with hydroxyl radical,
simulating AOPs (Advanced Oxidation Processes). AOPs are known for being highly
effective in wastewater management and natural water remediation. In this paper,
exhaustive research on the radical scavenging activity of a newly synthesized
coumarin derivative (4HCBH), as a representative of the series of coumarin-
benzohydrazides with high antioxidative potential was conducted. This study took into
consideration the pH value range significant for practically all living organisms (pH=7.0-
8.5). According to the experimentally obtained results, the 4HCBH showed an increase
in radical scavenging activity, following the slight increase in pH values, which
suggested that the formation of anionic form of 4HCBH is responsible for its antiradical
activity. Further investigations led to the postulation of a novel mechanistic approach
called Sequential Proton Loss Electron Transfer – Radical-Radical Coupling (SPLET-
RRC), in which, by a series of steps, a new, stable compound was formed.
Furthermore, it was demonstrated that the product generated through SPLET-RRC
showed lower toxicity than the parent molecule.",
publisher = "Elsevier",
journal = "Science of the Total Environment",
title = "Investigation of Novel Radical Scavenging Mechanisms in the Alkaline Environment: Green, Sustainable and Environmentally Friendly Antioxidative Agent(s)",
pages = "160319-169307",
volume = "912",
doi = "10.1016/j.scitotenv.2023.169307"
}

Antonijević, M., Avdović, E., Simijonović, D., Milanović, Ž., Žižić, M.,& Marković, Z.. (2024). Investigation of Novel Radical Scavenging Mechanisms in the Alkaline Environment: Green, Sustainable and Environmentally Friendly Antioxidative Agent(s). in Science of the Total Environment
Elsevier., 912, 169307-160319.
https://doi.org/10.1016/j.scitotenv.2023.169307

Antonijević M, Avdović E, Simijonović D, Milanović Ž, Žižić M, Marković Z. Investigation of Novel Radical Scavenging Mechanisms in the Alkaline Environment: Green, Sustainable and Environmentally Friendly Antioxidative Agent(s). in Science of the Total Environment. 2024;912:169307-160319.
doi:10.1016/j.scitotenv.2023.169307 .

Antonijević, Marko, Avdović, Edina, Simijonović, Dušica, Milanović, Žiko, Žižić, Milan, Marković, Zoran, "Investigation of Novel Radical Scavenging Mechanisms in the Alkaline Environment: Green, Sustainable and Environmentally Friendly Antioxidative Agent(s)" in Science of the Total Environment, 912 (2024):169307-160319,
https://doi.org/10.1016/j.scitotenv.2023.169307 . .