TY  - CONF
AU  - Bozic Cvijan, Bojana
AU  - Korać Jačić, Jelena
AU  - Stanković, Dalibor
AU  - Stanić, Marina
AU  - Popovic Bijelic, Ana
AU  - Bogdanović Pristov, Jelena
AU  - Spasojević, Ivan
AU  - Bajcetic, Milica
PY  - 2019
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/2847
AB  - Toxic effects of unconjugated bilirubin (BR) in neonatal hyperbilirubinemia have been related to redox and/or
coordinate interactions with Cu2+. However, the development and mechanisms of such interactions at physiological
pH have not been resolved. This study shows that BR reduces Cu2+ to Cu1+ in 1:1 stoichiometry.
Apparently, BR undergoes degradation, i.e. BR and Cu2+ do not form stable complexes. The binding of Cu2+ to
inorganic phosphates, liposomal phosphate groups, or to chelating drug penicillamine, impedes redox interactions
with BR. Cu1+ undergoes spontaneous oxidation by O2 resulting in hydrogen peroxide accumulation and
hydroxyl radical production. In relation to this, copper and BR induced synergistic oxidative/damaging effects
on erythrocytes membrane, which were alleviated by penicillamine. The production of reactive oxygen species
by BR and copper represents a plausible cause of BR toxic effects and cell damage in hyperbilirubinemia. Further
examination of therapeutic potentials of copper chelators in the treatment of severe neonatal hyperbilirubinemia
is needed.
PB  - Srpsko farmakološko društvo Beograd, Novi Sad
C3  - 14th Serbian Congress of Farmacologists and 4th Serbian Congress of Clinical Pharmacology with international participation
T1  - Penicillamine prevents damaging redox in vitro interactions of bilirubin and copper
EP  - 242
SP  - 240
UR  - https://hdl.handle.net/21.15107/rcub_rimsi_2847
ER  - 

@conference{
author = "Bozic Cvijan, Bojana and Korać Jačić, Jelena and Stanković, Dalibor and Stanić, Marina and Popovic Bijelic, Ana and Bogdanović Pristov, Jelena and Spasojević, Ivan and Bajcetic, Milica",
year = "2019",
abstract = "Toxic effects of unconjugated bilirubin (BR) in neonatal hyperbilirubinemia have been related to redox and/or
coordinate interactions with Cu2+. However, the development and mechanisms of such interactions at physiological
pH have not been resolved. This study shows that BR reduces Cu2+ to Cu1+ in 1:1 stoichiometry.
Apparently, BR undergoes degradation, i.e. BR and Cu2+ do not form stable complexes. The binding of Cu2+ to
inorganic phosphates, liposomal phosphate groups, or to chelating drug penicillamine, impedes redox interactions
with BR. Cu1+ undergoes spontaneous oxidation by O2 resulting in hydrogen peroxide accumulation and
hydroxyl radical production. In relation to this, copper and BR induced synergistic oxidative/damaging effects
on erythrocytes membrane, which were alleviated by penicillamine. The production of reactive oxygen species
by BR and copper represents a plausible cause of BR toxic effects and cell damage in hyperbilirubinemia. Further
examination of therapeutic potentials of copper chelators in the treatment of severe neonatal hyperbilirubinemia
is needed.",
publisher = "Srpsko farmakološko društvo Beograd, Novi Sad",
journal = "14th Serbian Congress of Farmacologists and 4th Serbian Congress of Clinical Pharmacology with international participation",
title = "Penicillamine prevents damaging redox in vitro interactions of bilirubin and copper",
pages = "242-240",
url = "https://hdl.handle.net/21.15107/rcub_rimsi_2847"
}

Bozic Cvijan, B., Korać Jačić, J., Stanković, D., Stanić, M., Popovic Bijelic, A., Bogdanović Pristov, J., Spasojević, I.,& Bajcetic, M.. (2019). Penicillamine prevents damaging redox in vitro interactions of bilirubin and copper. in 14th Serbian Congress of Farmacologists and 4th Serbian Congress of Clinical Pharmacology with international participation
Srpsko farmakološko društvo Beograd, Novi Sad., 240-242.
https://hdl.handle.net/21.15107/rcub_rimsi_2847

Bozic Cvijan B, Korać Jačić J, Stanković D, Stanić M, Popovic Bijelic A, Bogdanović Pristov J, Spasojević I, Bajcetic M. Penicillamine prevents damaging redox in vitro interactions of bilirubin and copper. in 14th Serbian Congress of Farmacologists and 4th Serbian Congress of Clinical Pharmacology with international participation. 2019;:240-242.
https://hdl.handle.net/21.15107/rcub_rimsi_2847 .

Bozic Cvijan, Bojana, Korać Jačić, Jelena, Stanković, Dalibor, Stanić, Marina, Popovic Bijelic, Ana, Bogdanović Pristov, Jelena, Spasojević, Ivan, Bajcetic, Milica, "Penicillamine prevents damaging redox in vitro interactions of bilirubin and copper" in 14th Serbian Congress of Farmacologists and 4th Serbian Congress of Clinical Pharmacology with international participation (2019):240-242,
https://hdl.handle.net/21.15107/rcub_rimsi_2847 .