TY  - JOUR
AU  - Bogdanović Pristov, Jelena
AU  - Opačić, Miloš
AU  - Bajčetić, Milica
AU  - Mandic, Vesna
AU  - Maglic, Dragana
AU  - Miković, Zeljko
AU  - Spasojević, Ivan
PY  - 2020
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1316
AB  - Oxidative status of maternal blood represents an important parameter of pregnancy that is involved in both, regulation of physiological processes and (if significantly altered) development of different pregnancy complications. Inherited thrombophilias represent genetic disorders that increase the risk of thromboembolism in pregnancy. Little is known about the impact of thrombophilia on the oxidative status of maternal blood. In this study, we analyzed oxidative status of blood of 56 women with pregnancies burdened by inherited thrombophilias. The status was established at three different trimesters using biochemical assays and electrochemical measurements, and it was compared to 10 age- and trimester-matching controls. Activities of superoxide dismutase, catalase, and glutathione reductase in the 1(st)and the 2(nd)trimester of thrombophilic pregnancy were lower than controls. Also, there was less oxidation in the plasma, according to higher concentration of reduced thiols and lower oxidation-reduction potential. Therefore, it appears that thrombophilic mothers do not experience oxidative stress in the circulation in the first two trimesters. However, the rise in GPx, GR and SOD activities in the 3(rd)trimester of thrombophilic pregnancy implies that the risk of oxidative stress is increased during the late pregnancy. These results are important for developing antioxidative treatment that could tackle thrombophilia-related pregnancy complications.
PB  - Public Library Science, San Francisco
T2  - PLoS One
T1  - Oxidative status of maternal blood in pregnancies burdened by inherited thrombophilias
IS  - 6
VL  - 15
DO  - 10.1371/journal.pone.0234253
ER  - 

@article{
author = "Bogdanović Pristov, Jelena and Opačić, Miloš and Bajčetić, Milica and Mandic, Vesna and Maglic, Dragana and Miković, Zeljko and Spasojević, Ivan",
year = "2020",
abstract = "Oxidative status of maternal blood represents an important parameter of pregnancy that is involved in both, regulation of physiological processes and (if significantly altered) development of different pregnancy complications. Inherited thrombophilias represent genetic disorders that increase the risk of thromboembolism in pregnancy. Little is known about the impact of thrombophilia on the oxidative status of maternal blood. In this study, we analyzed oxidative status of blood of 56 women with pregnancies burdened by inherited thrombophilias. The status was established at three different trimesters using biochemical assays and electrochemical measurements, and it was compared to 10 age- and trimester-matching controls. Activities of superoxide dismutase, catalase, and glutathione reductase in the 1(st)and the 2(nd)trimester of thrombophilic pregnancy were lower than controls. Also, there was less oxidation in the plasma, according to higher concentration of reduced thiols and lower oxidation-reduction potential. Therefore, it appears that thrombophilic mothers do not experience oxidative stress in the circulation in the first two trimesters. However, the rise in GPx, GR and SOD activities in the 3(rd)trimester of thrombophilic pregnancy implies that the risk of oxidative stress is increased during the late pregnancy. These results are important for developing antioxidative treatment that could tackle thrombophilia-related pregnancy complications.",
publisher = "Public Library Science, San Francisco",
journal = "PLoS One",
title = "Oxidative status of maternal blood in pregnancies burdened by inherited thrombophilias",
number = "6",
volume = "15",
doi = "10.1371/journal.pone.0234253"
}

Bogdanović Pristov, J., Opačić, M., Bajčetić, M., Mandic, V., Maglic, D., Miković, Z.,& Spasojević, I.. (2020). Oxidative status of maternal blood in pregnancies burdened by inherited thrombophilias. in PLoS One
Public Library Science, San Francisco., 15(6).
https://doi.org/10.1371/journal.pone.0234253

Bogdanović Pristov J, Opačić M, Bajčetić M, Mandic V, Maglic D, Miković Z, Spasojević I. Oxidative status of maternal blood in pregnancies burdened by inherited thrombophilias. in PLoS One. 2020;15(6).
doi:10.1371/journal.pone.0234253 .

Bogdanović Pristov, Jelena, Opačić, Miloš, Bajčetić, Milica, Mandic, Vesna, Maglic, Dragana, Miković, Zeljko, Spasojević, Ivan, "Oxidative status of maternal blood in pregnancies burdened by inherited thrombophilias" in PLoS One, 15, no. 6 (2020),
https://doi.org/10.1371/journal.pone.0234253 . .

TY  - JOUR
AU  - Bozic, Bojana
AU  - Korać Jačić, Jelena
AU  - Stanković, Dalibor M.
AU  - Stanić, Marina
AU  - Romanović, Mima
AU  - Bogdanović Pristov, Jelena
AU  - Spasic, Snežana
AU  - Popovic-Bijelic, Ana
AU  - Spasojević, Ivan
AU  - Bajčetić, Milica
PY  - 2018
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1111
AB  - An increase in the copper pool in body fluids has been related to a number of pathological conditions, including infections. Copper ions may affect antibiotics via the formation of coordination bonds and/or redox reactions. Herein, we analyzed the interactions of Cu2+ with eight beta-lactam antibiotics using UV-Vis spectrophotometry, EPR spectroscopy, and electrochemical methods. Penicillin G did not show any detectable interactions with Cu2+. Ampicillin, amoxicillin and cephalexin formed stable colored complexes with octahedral coordination environment of Cu2+ with tetragonal distortion, and primary amine group as the site of coordinate bond formation. These beta-lactams increased the solubility of Cu2+ in the phosphate buffer. Ceftazidime and Cu2+ formed a complex with a similar geometry and gave rise to an organic radical. Ceftriaxone-Cu2+ complex appears to exhibit different geometry. All complexes showed 1: 1 stoichiometry. Cefaclor reduced Cu2+ to Cu1+ that further reacted with molecular oxygen to produce hydrogen peroxide. Finally, meropenem underwent degradation in the presence of copper. The analysis of activity against Escherichia coli and Staphylococcus aureus showed that the effects of meropenem, amoxicillin, ampicillin, and ceftriaxone were significantly hindered in the presence of copper ions. The interactions with copper ions should be taken into account regarding the problem of antibiotic resistance and in the selection of the most efficient antimicrobial therapy for patients with altered copper homeostasis.
PB  - Elsevier Science Inc, New York
T2  - Free Radical Biology and Medicine
T1  - Coordination and redox interactions of beta-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity
EP  - 285
SP  - 279
VL  - 129
DO  - 10.1016/j.freeradbiomed.2018.09.038
ER  - 

@article{
author = "Bozic, Bojana and Korać Jačić, Jelena and Stanković, Dalibor M. and Stanić, Marina and Romanović, Mima and Bogdanović Pristov, Jelena and Spasic, Snežana and Popovic-Bijelic, Ana and Spasojević, Ivan and Bajčetić, Milica",
year = "2018",
abstract = "An increase in the copper pool in body fluids has been related to a number of pathological conditions, including infections. Copper ions may affect antibiotics via the formation of coordination bonds and/or redox reactions. Herein, we analyzed the interactions of Cu2+ with eight beta-lactam antibiotics using UV-Vis spectrophotometry, EPR spectroscopy, and electrochemical methods. Penicillin G did not show any detectable interactions with Cu2+. Ampicillin, amoxicillin and cephalexin formed stable colored complexes with octahedral coordination environment of Cu2+ with tetragonal distortion, and primary amine group as the site of coordinate bond formation. These beta-lactams increased the solubility of Cu2+ in the phosphate buffer. Ceftazidime and Cu2+ formed a complex with a similar geometry and gave rise to an organic radical. Ceftriaxone-Cu2+ complex appears to exhibit different geometry. All complexes showed 1: 1 stoichiometry. Cefaclor reduced Cu2+ to Cu1+ that further reacted with molecular oxygen to produce hydrogen peroxide. Finally, meropenem underwent degradation in the presence of copper. The analysis of activity against Escherichia coli and Staphylococcus aureus showed that the effects of meropenem, amoxicillin, ampicillin, and ceftriaxone were significantly hindered in the presence of copper ions. The interactions with copper ions should be taken into account regarding the problem of antibiotic resistance and in the selection of the most efficient antimicrobial therapy for patients with altered copper homeostasis.",
publisher = "Elsevier Science Inc, New York",
journal = "Free Radical Biology and Medicine",
title = "Coordination and redox interactions of beta-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity",
pages = "285-279",
volume = "129",
doi = "10.1016/j.freeradbiomed.2018.09.038"
}

Bozic, B., Korać Jačić, J., Stanković, D. M., Stanić, M., Romanović, M., Bogdanović Pristov, J., Spasic, S., Popovic-Bijelic, A., Spasojević, I.,& Bajčetić, M.. (2018). Coordination and redox interactions of beta-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity. in Free Radical Biology and Medicine
Elsevier Science Inc, New York., 129, 279-285.
https://doi.org/10.1016/j.freeradbiomed.2018.09.038

Bozic B, Korać Jačić J, Stanković DM, Stanić M, Romanović M, Bogdanović Pristov J, Spasic S, Popovic-Bijelic A, Spasojević I, Bajčetić M. Coordination and redox interactions of beta-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity. in Free Radical Biology and Medicine. 2018;129:279-285.
doi:10.1016/j.freeradbiomed.2018.09.038 .

Bozic, Bojana, Korać Jačić, Jelena, Stanković, Dalibor M., Stanić, Marina, Romanović, Mima, Bogdanović Pristov, Jelena, Spasic, Snežana, Popovic-Bijelic, Ana, Spasojević, Ivan, Bajčetić, Milica, "Coordination and redox interactions of beta-lactam antibiotics with Cu2+ in physiological settings and the impact on antibacterial activity" in Free Radical Biology and Medicine, 129 (2018):279-285,
https://doi.org/10.1016/j.freeradbiomed.2018.09.038 . .

TY  - JOUR
AU  - Bozic, Bojana
AU  - Korać Jačić, Jelena
AU  - Stanković, Dalibor M.
AU  - Stanić, Marina
AU  - Popovic-Bijelic, Ana
AU  - Bogdanović Pristov, Jelena
AU  - Spasojević, Ivan
AU  - Bajčetić, Milica
PY  - 2017
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1044
AB  - Toxic effects of unconjugated bilirubin (BR) in neonatal hyperbilirubinemia have been related to redox and/or coordinate interactions with Cu2+. However, the development and mechanisms of such interactions at physiological pH have not been resolved. This study shows that BR reduces Cu2+ to Cu1+ in 1:1 stoichiometry. Apparently, BR undergoes degradation, i.e. BR and Cu2+ do not form stable complexes. The binding of Cu2+ to inorganic phosphates, liposomal phosphate groups, or to chelating drug penicillamine, impedes redox interactions with BR. Cu1+ undergoes spontaneous oxidation by O-2 resulting in hydrogen peroxide accumulation and hydroxyl radical production. In relation to this, copper and BR induced synergistic oxidative/damaging effects on erythrocytes membrane, which were alleviated by penicillamine. The production of reactive oxygen species by BR and copper represents a plausible cause of BR toxic effects and cell damage in hyperbilirubinemia. Further examination of therapeutic potentials of copper chelators in the treatment of severe neonatal hyperbilirubinemia is needed.
PB  - Elsevier Ireland Ltd, Clare
T2  - Chemico-Biological Interactions
T1  - Mechanisms of redox interactions of bilirubin with copper and the effects of penicillamine
EP  - 134
SP  - 129
VL  - 278
DO  - 10.1016/j.cbi.2017.10.022
ER  - 

@article{
author = "Bozic, Bojana and Korać Jačić, Jelena and Stanković, Dalibor M. and Stanić, Marina and Popovic-Bijelic, Ana and Bogdanović Pristov, Jelena and Spasojević, Ivan and Bajčetić, Milica",
year = "2017",
abstract = "Toxic effects of unconjugated bilirubin (BR) in neonatal hyperbilirubinemia have been related to redox and/or coordinate interactions with Cu2+. However, the development and mechanisms of such interactions at physiological pH have not been resolved. This study shows that BR reduces Cu2+ to Cu1+ in 1:1 stoichiometry. Apparently, BR undergoes degradation, i.e. BR and Cu2+ do not form stable complexes. The binding of Cu2+ to inorganic phosphates, liposomal phosphate groups, or to chelating drug penicillamine, impedes redox interactions with BR. Cu1+ undergoes spontaneous oxidation by O-2 resulting in hydrogen peroxide accumulation and hydroxyl radical production. In relation to this, copper and BR induced synergistic oxidative/damaging effects on erythrocytes membrane, which were alleviated by penicillamine. The production of reactive oxygen species by BR and copper represents a plausible cause of BR toxic effects and cell damage in hyperbilirubinemia. Further examination of therapeutic potentials of copper chelators in the treatment of severe neonatal hyperbilirubinemia is needed.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Chemico-Biological Interactions",
title = "Mechanisms of redox interactions of bilirubin with copper and the effects of penicillamine",
pages = "134-129",
volume = "278",
doi = "10.1016/j.cbi.2017.10.022"
}

Bozic, B., Korać Jačić, J., Stanković, D. M., Stanić, M., Popovic-Bijelic, A., Bogdanović Pristov, J., Spasojević, I.,& Bajčetić, M.. (2017). Mechanisms of redox interactions of bilirubin with copper and the effects of penicillamine. in Chemico-Biological Interactions
Elsevier Ireland Ltd, Clare., 278, 129-134.
https://doi.org/10.1016/j.cbi.2017.10.022

Bozic B, Korać Jačić J, Stanković DM, Stanić M, Popovic-Bijelic A, Bogdanović Pristov J, Spasojević I, Bajčetić M. Mechanisms of redox interactions of bilirubin with copper and the effects of penicillamine. in Chemico-Biological Interactions. 2017;278:129-134.
doi:10.1016/j.cbi.2017.10.022 .

Bozic, Bojana, Korać Jačić, Jelena, Stanković, Dalibor M., Stanić, Marina, Popovic-Bijelic, Ana, Bogdanović Pristov, Jelena, Spasojević, Ivan, Bajčetić, Milica, "Mechanisms of redox interactions of bilirubin with copper and the effects of penicillamine" in Chemico-Biological Interactions, 278 (2017):129-134,
https://doi.org/10.1016/j.cbi.2017.10.022 . .

TY  - JOUR
AU  - Kezic, Aleksandra
AU  - Spasojević, Ivan
AU  - Lezaic, Visnja
AU  - Bajčetić, Milica
PY  - 2016
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/993
AB  - Kidney ischemia/reperfusion injury emerges in various clinical settings as a great problem complicating the course and outcome. Ischemia/reperfusion injury is still an unsolved puzzle with a great diversity of investigational approaches, putting the focus on oxidative stress and mitochondria. Mitochondria are both sources and targets of ROS. They participate in initiation and progression of kidney ischemia/reperfusion injury linking oxidative stress, inflammation, and cell death. The dependence of kidney proximal tubule cells on oxidative mitochondrial metabolism makes them particularly prone to harmful effects of mitochondrial damage. The administration of antioxidants has been used as a way to prevent and treat kidney ischemia/reperfusion injury for a long time. Recently a new method based on mitochondria-targeted antioxidants has become the focus of interest. Here we review the current status of results achieved in numerous studies investigating these novel compounds in ischemia/reperfusion injury which specifically target mitochondria such asMitoQ, Szeto-Schiller (SS) peptides (Bendavia), SkQ1 and SkQR1, and superoxide dismutase mimics. Based on the favorable results obtained in the studies that have examined myocardial ischemia/reperfusion injury, ongoing clinical trials investigate the efficacy of some novel therapeutics in preventing myocardial infarct. This also implies future strategies in preventing kidney ischemia/reperfusion injury.
PB  - Hindawi Ltd, London
T2  - Oxidative Medicine and Cellular Longevity
T1  - Mitochondria-Targeted Antioxidants: Future Perspectives in Kidney Ischemia Reperfusion Injury
VL  - 2016
DO  - 10.1155/2016/2950503
ER  - 

@article{
author = "Kezic, Aleksandra and Spasojević, Ivan and Lezaic, Visnja and Bajčetić, Milica",
year = "2016",
abstract = "Kidney ischemia/reperfusion injury emerges in various clinical settings as a great problem complicating the course and outcome. Ischemia/reperfusion injury is still an unsolved puzzle with a great diversity of investigational approaches, putting the focus on oxidative stress and mitochondria. Mitochondria are both sources and targets of ROS. They participate in initiation and progression of kidney ischemia/reperfusion injury linking oxidative stress, inflammation, and cell death. The dependence of kidney proximal tubule cells on oxidative mitochondrial metabolism makes them particularly prone to harmful effects of mitochondrial damage. The administration of antioxidants has been used as a way to prevent and treat kidney ischemia/reperfusion injury for a long time. Recently a new method based on mitochondria-targeted antioxidants has become the focus of interest. Here we review the current status of results achieved in numerous studies investigating these novel compounds in ischemia/reperfusion injury which specifically target mitochondria such asMitoQ, Szeto-Schiller (SS) peptides (Bendavia), SkQ1 and SkQR1, and superoxide dismutase mimics. Based on the favorable results obtained in the studies that have examined myocardial ischemia/reperfusion injury, ongoing clinical trials investigate the efficacy of some novel therapeutics in preventing myocardial infarct. This also implies future strategies in preventing kidney ischemia/reperfusion injury.",
publisher = "Hindawi Ltd, London",
journal = "Oxidative Medicine and Cellular Longevity",
title = "Mitochondria-Targeted Antioxidants: Future Perspectives in Kidney Ischemia Reperfusion Injury",
volume = "2016",
doi = "10.1155/2016/2950503"
}

Kezic, A., Spasojević, I., Lezaic, V.,& Bajčetić, M.. (2016). Mitochondria-Targeted Antioxidants: Future Perspectives in Kidney Ischemia Reperfusion Injury. in Oxidative Medicine and Cellular Longevity
Hindawi Ltd, London., 2016.
https://doi.org/10.1155/2016/2950503

Kezic A, Spasojević I, Lezaic V, Bajčetić M. Mitochondria-Targeted Antioxidants: Future Perspectives in Kidney Ischemia Reperfusion Injury. in Oxidative Medicine and Cellular Longevity. 2016;2016.
doi:10.1155/2016/2950503 .

Kezic, Aleksandra, Spasojević, Ivan, Lezaic, Visnja, Bajčetić, Milica, "Mitochondria-Targeted Antioxidants: Future Perspectives in Kidney Ischemia Reperfusion Injury" in Oxidative Medicine and Cellular Longevity, 2016 (2016),
https://doi.org/10.1155/2016/2950503 . .

TY  - JOUR
AU  - Bogosavljević, Vojislav
AU  - Bajčetić, Milica
AU  - Spasojević, Ivan
PY  - 2015
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/823
AB  - Objectives: Comparison of redox conditions in malignant and benign tumours is essential for understanding the role of reactive oxygen species in the pathophysiology of aggressive cancer profiles. Here we compare antioxidative systems in highly malignant brain tumour - glioblastoma multiforme (GBM), and in meningioma, a benign brain tumour. Methods: Tumour tissues and blood of 67 GBM patients (mean age: 52.9 +/- 11.5 years) and 67 meningioma patients (59.2 +/- 10.2 years), and blood of 30 control subjects (50.8 +/- 12.8 years) were analysed via biochemical assays. Results: Components of glutathione system, which is responsible for H2O2 removal, showed lower activity/level in GBM: glutathione peroxidase (GBM: 9.90 +/- 0.22; meningioma: 11.78 +/- 0.23 U/mg of proteins; P  lt  0.001), glutathione reductase (GBM: 3.83 +/- 0.13; meningioma: 4.67 +/- 0.11 U/mg of proteins; P  lt  0.001), and glutathione (GBM: 6.70 +/- 0.12; meningioma: 7.58 +/- 0.14 mu mol/g of tissue; P  lt  0.001). In contrast, the rank order of glutathione reductase activity and glutathione level in erythrocytes was: GBM > meningioma > control. Superoxide dismutase and catalase activities were lower in the blood of cancer patients compared to controls. Discussion: Cells of malignant brain tumour show down-regulated antioxidative system which might result in increased levels of H2O2 compared to benign tumour tissue.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Redox Report
T1  - Comparative analysis of antioxidative systems in malignant and benign brain tumours
EP  - 74
IS  - 2
SP  - 69
VL  - 20
DO  - 10.1179/1351000214Y.0000000106
ER  - 

@article{
author = "Bogosavljević, Vojislav and Bajčetić, Milica and Spasojević, Ivan",
year = "2015",
abstract = "Objectives: Comparison of redox conditions in malignant and benign tumours is essential for understanding the role of reactive oxygen species in the pathophysiology of aggressive cancer profiles. Here we compare antioxidative systems in highly malignant brain tumour - glioblastoma multiforme (GBM), and in meningioma, a benign brain tumour. Methods: Tumour tissues and blood of 67 GBM patients (mean age: 52.9 +/- 11.5 years) and 67 meningioma patients (59.2 +/- 10.2 years), and blood of 30 control subjects (50.8 +/- 12.8 years) were analysed via biochemical assays. Results: Components of glutathione system, which is responsible for H2O2 removal, showed lower activity/level in GBM: glutathione peroxidase (GBM: 9.90 +/- 0.22; meningioma: 11.78 +/- 0.23 U/mg of proteins; P  lt  0.001), glutathione reductase (GBM: 3.83 +/- 0.13; meningioma: 4.67 +/- 0.11 U/mg of proteins; P  lt  0.001), and glutathione (GBM: 6.70 +/- 0.12; meningioma: 7.58 +/- 0.14 mu mol/g of tissue; P  lt  0.001). In contrast, the rank order of glutathione reductase activity and glutathione level in erythrocytes was: GBM > meningioma > control. Superoxide dismutase and catalase activities were lower in the blood of cancer patients compared to controls. Discussion: Cells of malignant brain tumour show down-regulated antioxidative system which might result in increased levels of H2O2 compared to benign tumour tissue.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Redox Report",
title = "Comparative analysis of antioxidative systems in malignant and benign brain tumours",
pages = "74-69",
number = "2",
volume = "20",
doi = "10.1179/1351000214Y.0000000106"
}

Bogosavljević, V., Bajčetić, M.,& Spasojević, I.. (2015). Comparative analysis of antioxidative systems in malignant and benign brain tumours. in Redox Report
Taylor & Francis Ltd, Abingdon., 20(2), 69-74.
https://doi.org/10.1179/1351000214Y.0000000106

Bogosavljević V, Bajčetić M, Spasojević I. Comparative analysis of antioxidative systems in malignant and benign brain tumours. in Redox Report. 2015;20(2):69-74.
doi:10.1179/1351000214Y.0000000106 .

Bogosavljević, Vojislav, Bajčetić, Milica, Spasojević, Ivan, "Comparative analysis of antioxidative systems in malignant and benign brain tumours" in Redox Report, 20, no. 2 (2015):69-74,
https://doi.org/10.1179/1351000214Y.0000000106 . .

TY  - JOUR
AU  - Bajčetić, Milica
AU  - Spasic, Snežana
AU  - Spasojević, Ivan
PY  - 2014
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/818
AB  - Neonatal sepsis is one of the most fulminating conditions in neonatal intensive care units. Antipathogen and supportive care are administered routinely, but do not deliver satisfactory results. In addition, the efforts to treat neonatal sepsis with anti-inflammatory agents have generally shown to be futile. The accumulating data imply that intracellular redox changes intertwined into neonatal sepsis redox cycle represent the main cause of dysfunction of mitochondria and cells in neonatal sepsis. Our aim here is to support the new philosophy in neonatal sepsis treatment, which involves the integration of mechanisms that are responsible for cellular dysfunction and organ failure, the recognition of the most important targets, and the selection of safe agents that can stop the neonatal sepsis redox cycle by hitting the hot spots. Redox-active agents that could be beneficial for neonatal sepsis treatment according to these criteria include lactoferrin, interleukin 10, zinc and selenium supplements, ibuprofen, edaravone, and pentoxifylline.
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Shock
T1  - Redox therapy in neonatal sepsis: reasons, targets, strategy, and agents
EP  - 184
IS  - 3
SP  - 179
VL  - 42
DO  - 10.1097/SHK.0000000000000198
ER  - 

@article{
author = "Bajčetić, Milica and Spasic, Snežana and Spasojević, Ivan",
year = "2014",
abstract = "Neonatal sepsis is one of the most fulminating conditions in neonatal intensive care units. Antipathogen and supportive care are administered routinely, but do not deliver satisfactory results. In addition, the efforts to treat neonatal sepsis with anti-inflammatory agents have generally shown to be futile. The accumulating data imply that intracellular redox changes intertwined into neonatal sepsis redox cycle represent the main cause of dysfunction of mitochondria and cells in neonatal sepsis. Our aim here is to support the new philosophy in neonatal sepsis treatment, which involves the integration of mechanisms that are responsible for cellular dysfunction and organ failure, the recognition of the most important targets, and the selection of safe agents that can stop the neonatal sepsis redox cycle by hitting the hot spots. Redox-active agents that could be beneficial for neonatal sepsis treatment according to these criteria include lactoferrin, interleukin 10, zinc and selenium supplements, ibuprofen, edaravone, and pentoxifylline.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Shock",
title = "Redox therapy in neonatal sepsis: reasons, targets, strategy, and agents",
pages = "184-179",
number = "3",
volume = "42",
doi = "10.1097/SHK.0000000000000198"
}

Bajčetić, M., Spasic, S.,& Spasojević, I.. (2014). Redox therapy in neonatal sepsis: reasons, targets, strategy, and agents. in Shock
Lippincott Williams & Wilkins, Philadelphia., 42(3), 179-184.
https://doi.org/10.1097/SHK.0000000000000198

Bajčetić M, Spasic S, Spasojević I. Redox therapy in neonatal sepsis: reasons, targets, strategy, and agents. in Shock. 2014;42(3):179-184.
doi:10.1097/SHK.0000000000000198 .

Bajčetić, Milica, Spasic, Snežana, Spasojević, Ivan, "Redox therapy in neonatal sepsis: reasons, targets, strategy, and agents" in Shock, 42, no. 3 (2014):179-184,
https://doi.org/10.1097/SHK.0000000000000198 . .

TY  - JOUR
AU  - Bajčetić, Milica
AU  - Otasević, Biljana
AU  - Bozinovic-Prekajski, Niveska
AU  - Spasic, Snežana
AU  - Spasojević, Ivan
PY  - 2014
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/817
AB  - Background: Vitamin E is routinely supplemented to preterm babies, including those with neonatal sepsis. Our aim was to examine the effects of neonatal sepsis and vitamin E on antioxidative system (AOS) in the blood. Methods: A prospective, randomized, open label study involved 65 preterm neonates (control/sepsis - 34/31), which were divided into two subgroups - non-supplemented and supplemented with vitamin E (25 IU/day for 60 days). The activities of superoxide dismutase, catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) were determined in erythrocytes at days 0, 30, and 60, following sepsis diagnosis. Results: There was no difference in the activity of AOS between controls and neonates with ongoing sepsis. At 60 days, septic neonates showed higher CAT activity compared to controls (P = 0.027), and lower GPx activity compared to 0 days (P = 0.022). The later was mitigated by vitamin E, which on the other hand provoked lower GPx activity at 30 days, compared to untreated septic neonates (P = 0.014). In addition, vitamin E suppressed GR activity in septic neonates (P = 0.025 and P = 0.017 at 30 and 60 days). Finally, vitamin E supplementation in control neonates provoked a significant increase of GPx activity (P = 0.015 at 60 days). Conclusions: The absence of altered redox settings in the blood of neonates during sepsis episode, and vitamin E-provoked decrease in the activity of some components of AOS, suggest that the supplementation of vitamin E in these patients might not be rational.
PB  - Sage Publications Inc, Thousand Oaks
T2  - Annals of Clinical Biochemistry
T1  - Antioxidative system in the erythrocytes of preterm neonates with sepsis: the effects of vitamin E supplementation
EP  - 556
IS  - 5
SP  - 550
VL  - 51
DO  - 10.1177/0004563213503317
ER  - 

@article{
author = "Bajčetić, Milica and Otasević, Biljana and Bozinovic-Prekajski, Niveska and Spasic, Snežana and Spasojević, Ivan",
year = "2014",
abstract = "Background: Vitamin E is routinely supplemented to preterm babies, including those with neonatal sepsis. Our aim was to examine the effects of neonatal sepsis and vitamin E on antioxidative system (AOS) in the blood. Methods: A prospective, randomized, open label study involved 65 preterm neonates (control/sepsis - 34/31), which were divided into two subgroups - non-supplemented and supplemented with vitamin E (25 IU/day for 60 days). The activities of superoxide dismutase, catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) were determined in erythrocytes at days 0, 30, and 60, following sepsis diagnosis. Results: There was no difference in the activity of AOS between controls and neonates with ongoing sepsis. At 60 days, septic neonates showed higher CAT activity compared to controls (P = 0.027), and lower GPx activity compared to 0 days (P = 0.022). The later was mitigated by vitamin E, which on the other hand provoked lower GPx activity at 30 days, compared to untreated septic neonates (P = 0.014). In addition, vitamin E suppressed GR activity in septic neonates (P = 0.025 and P = 0.017 at 30 and 60 days). Finally, vitamin E supplementation in control neonates provoked a significant increase of GPx activity (P = 0.015 at 60 days). Conclusions: The absence of altered redox settings in the blood of neonates during sepsis episode, and vitamin E-provoked decrease in the activity of some components of AOS, suggest that the supplementation of vitamin E in these patients might not be rational.",
publisher = "Sage Publications Inc, Thousand Oaks",
journal = "Annals of Clinical Biochemistry",
title = "Antioxidative system in the erythrocytes of preterm neonates with sepsis: the effects of vitamin E supplementation",
pages = "556-550",
number = "5",
volume = "51",
doi = "10.1177/0004563213503317"
}

Bajčetić, M., Otasević, B., Bozinovic-Prekajski, N., Spasic, S.,& Spasojević, I.. (2014). Antioxidative system in the erythrocytes of preterm neonates with sepsis: the effects of vitamin E supplementation. in Annals of Clinical Biochemistry
Sage Publications Inc, Thousand Oaks., 51(5), 550-556.
https://doi.org/10.1177/0004563213503317

Bajčetić M, Otasević B, Bozinovic-Prekajski N, Spasic S, Spasojević I. Antioxidative system in the erythrocytes of preterm neonates with sepsis: the effects of vitamin E supplementation. in Annals of Clinical Biochemistry. 2014;51(5):550-556.
doi:10.1177/0004563213503317 .

Bajčetić, Milica, Otasević, Biljana, Bozinovic-Prekajski, Niveska, Spasic, Snežana, Spasojević, Ivan, "Antioxidative system in the erythrocytes of preterm neonates with sepsis: the effects of vitamin E supplementation" in Annals of Clinical Biochemistry, 51, no. 5 (2014):550-556,
https://doi.org/10.1177/0004563213503317 . .