TY  - JOUR
AU  - Bogdanović Pristov, Jelena
AU  - Opačić, Miloš
AU  - Bajčetić, Milica
AU  - Mandic, Vesna
AU  - Maglic, Dragana
AU  - Miković, Zeljko
AU  - Spasojević, Ivan
PY  - 2020
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1316
AB  - Oxidative status of maternal blood represents an important parameter of pregnancy that is involved in both, regulation of physiological processes and (if significantly altered) development of different pregnancy complications. Inherited thrombophilias represent genetic disorders that increase the risk of thromboembolism in pregnancy. Little is known about the impact of thrombophilia on the oxidative status of maternal blood. In this study, we analyzed oxidative status of blood of 56 women with pregnancies burdened by inherited thrombophilias. The status was established at three different trimesters using biochemical assays and electrochemical measurements, and it was compared to 10 age- and trimester-matching controls. Activities of superoxide dismutase, catalase, and glutathione reductase in the 1(st)and the 2(nd)trimester of thrombophilic pregnancy were lower than controls. Also, there was less oxidation in the plasma, according to higher concentration of reduced thiols and lower oxidation-reduction potential. Therefore, it appears that thrombophilic mothers do not experience oxidative stress in the circulation in the first two trimesters. However, the rise in GPx, GR and SOD activities in the 3(rd)trimester of thrombophilic pregnancy implies that the risk of oxidative stress is increased during the late pregnancy. These results are important for developing antioxidative treatment that could tackle thrombophilia-related pregnancy complications.
PB  - Public Library Science, San Francisco
T2  - PLoS One
T1  - Oxidative status of maternal blood in pregnancies burdened by inherited thrombophilias
IS  - 6
VL  - 15
DO  - 10.1371/journal.pone.0234253
ER  - 

@article{
author = "Bogdanović Pristov, Jelena and Opačić, Miloš and Bajčetić, Milica and Mandic, Vesna and Maglic, Dragana and Miković, Zeljko and Spasojević, Ivan",
year = "2020",
abstract = "Oxidative status of maternal blood represents an important parameter of pregnancy that is involved in both, regulation of physiological processes and (if significantly altered) development of different pregnancy complications. Inherited thrombophilias represent genetic disorders that increase the risk of thromboembolism in pregnancy. Little is known about the impact of thrombophilia on the oxidative status of maternal blood. In this study, we analyzed oxidative status of blood of 56 women with pregnancies burdened by inherited thrombophilias. The status was established at three different trimesters using biochemical assays and electrochemical measurements, and it was compared to 10 age- and trimester-matching controls. Activities of superoxide dismutase, catalase, and glutathione reductase in the 1(st)and the 2(nd)trimester of thrombophilic pregnancy were lower than controls. Also, there was less oxidation in the plasma, according to higher concentration of reduced thiols and lower oxidation-reduction potential. Therefore, it appears that thrombophilic mothers do not experience oxidative stress in the circulation in the first two trimesters. However, the rise in GPx, GR and SOD activities in the 3(rd)trimester of thrombophilic pregnancy implies that the risk of oxidative stress is increased during the late pregnancy. These results are important for developing antioxidative treatment that could tackle thrombophilia-related pregnancy complications.",
publisher = "Public Library Science, San Francisco",
journal = "PLoS One",
title = "Oxidative status of maternal blood in pregnancies burdened by inherited thrombophilias",
number = "6",
volume = "15",
doi = "10.1371/journal.pone.0234253"
}

Bogdanović Pristov, J., Opačić, M., Bajčetić, M., Mandic, V., Maglic, D., Miković, Z.,& Spasojević, I.. (2020). Oxidative status of maternal blood in pregnancies burdened by inherited thrombophilias. in PLoS One
Public Library Science, San Francisco., 15(6).
https://doi.org/10.1371/journal.pone.0234253

Bogdanović Pristov J, Opačić M, Bajčetić M, Mandic V, Maglic D, Miković Z, Spasojević I. Oxidative status of maternal blood in pregnancies burdened by inherited thrombophilias. in PLoS One. 2020;15(6).
doi:10.1371/journal.pone.0234253 .

Bogdanović Pristov, Jelena, Opačić, Miloš, Bajčetić, Milica, Mandic, Vesna, Maglic, Dragana, Miković, Zeljko, Spasojević, Ivan, "Oxidative status of maternal blood in pregnancies burdened by inherited thrombophilias" in PLoS One, 15, no. 6 (2020),
https://doi.org/10.1371/journal.pone.0234253 . .

TY  - JOUR
AU  - Bogdanović Pristov, Jelena
AU  - Maglic, Dragana
AU  - Opačić, Miloš
AU  - Mandic, Vesna
AU  - Miković, Zeljko
AU  - Spasić, Mihajlo
AU  - Spasojević, Ivan
PY  - 2012
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/585
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Thrombosis Research
T1  - Ante- and postpartum redox status of blood in women with inherited thrombophilia treated with heparin
EP  - 829
IS  - 5
SP  - 826
VL  - 130
DO  - 10.1016/j.thromres.2012.08.310
ER  - 

@article{
author = "Bogdanović Pristov, Jelena and Maglic, Dragana and Opačić, Miloš and Mandic, Vesna and Miković, Zeljko and Spasić, Mihajlo and Spasojević, Ivan",
year = "2012",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Thrombosis Research",
title = "Ante- and postpartum redox status of blood in women with inherited thrombophilia treated with heparin",
pages = "829-826",
number = "5",
volume = "130",
doi = "10.1016/j.thromres.2012.08.310"
}

Bogdanović Pristov, J., Maglic, D., Opačić, M., Mandic, V., Miković, Z., Spasić, M.,& Spasojević, I.. (2012). Ante- and postpartum redox status of blood in women with inherited thrombophilia treated with heparin. in Thrombosis Research
Pergamon-Elsevier Science Ltd, Oxford., 130(5), 826-829.
https://doi.org/10.1016/j.thromres.2012.08.310

Bogdanović Pristov J, Maglic D, Opačić M, Mandic V, Miković Z, Spasić M, Spasojević I. Ante- and postpartum redox status of blood in women with inherited thrombophilia treated with heparin. in Thrombosis Research. 2012;130(5):826-829.
doi:10.1016/j.thromres.2012.08.310 .

Bogdanović Pristov, Jelena, Maglic, Dragana, Opačić, Miloš, Mandic, Vesna, Miković, Zeljko, Spasić, Mihajlo, Spasojević, Ivan, "Ante- and postpartum redox status of blood in women with inherited thrombophilia treated with heparin" in Thrombosis Research, 130, no. 5 (2012):826-829,
https://doi.org/10.1016/j.thromres.2012.08.310 . .