TY  - JOUR
AU  - Bijelic, Dunja D.
AU  - Milicević, Katarina
AU  - Lazarević, Milica N.
AU  - Miljković, Đorđe
AU  - Bogdanović Pristov, Jelena
AU  - Savić, Danijela Z
AU  - Petković, Branka
AU  - Andjus, Pavle R.
AU  - Momcilović, Miljana
AU  - Nikolić, Ljiljana M.
PY  - 2020
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1317
AB  - Interaction between autoreactive immune cells and astroglia is an important part of the pathologic processes that fuel neurodegeneration in multiple sclerosis. In this inflammatory disease, immune cells enter into the central nervous system (CNS) and they spread through CNS parenchyma, but the impact of these autoreactive immune cells on the activity pattern of astrocytes has not been defined. By exploiting naive astrocytes in culture and CNS-infiltrated immune cells (CNS IICs) isolated from rat with experimental autoimmune encephalomyelitis (EAE), here we demonstrate previously unrecognized properties of immune cell-astrocyte interaction. We show that CNS IICs but not the peripheral immune cell application, evokes a rapid and vigorous intracellular Ca(2+)increase in astrocytes by promoting glial release of ATP. ATP propagated Ca(2+)elevation through glial purinergic P2X7 receptor activation by the hemichannel-dependent nucleotide release mechanism. Astrocyte Ca(2+)increase is specifically triggered by the autoreactive CD4(+)T-cell application and these two cell types exhibit close spatial interaction in EAE. Therefore, Ca(2+)signals may mediate a rapid astroglial response to the autoreactive immune cells in their local environment. This property of immune cell-astrocyte interaction may be important to consider in studies interrogating CNS autoimmune disease.
PB  - Wiley, Hoboken
T2  - Journal of Neuroscience Research
T1  - Central nervous system-infiltrated immune cells induce calcium increase in astrocytes via astroglial purinergic signaling
EP  - 2332
IS  - 11
SP  - 2317
VL  - 98
DO  - 10.1002/jnr.24699
ER  - 

@article{
author = "Bijelic, Dunja D. and Milicević, Katarina and Lazarević, Milica N. and Miljković, Đorđe and Bogdanović Pristov, Jelena and Savić, Danijela Z and Petković, Branka and Andjus, Pavle R. and Momcilović, Miljana and Nikolić, Ljiljana M.",
year = "2020",
abstract = "Interaction between autoreactive immune cells and astroglia is an important part of the pathologic processes that fuel neurodegeneration in multiple sclerosis. In this inflammatory disease, immune cells enter into the central nervous system (CNS) and they spread through CNS parenchyma, but the impact of these autoreactive immune cells on the activity pattern of astrocytes has not been defined. By exploiting naive astrocytes in culture and CNS-infiltrated immune cells (CNS IICs) isolated from rat with experimental autoimmune encephalomyelitis (EAE), here we demonstrate previously unrecognized properties of immune cell-astrocyte interaction. We show that CNS IICs but not the peripheral immune cell application, evokes a rapid and vigorous intracellular Ca(2+)increase in astrocytes by promoting glial release of ATP. ATP propagated Ca(2+)elevation through glial purinergic P2X7 receptor activation by the hemichannel-dependent nucleotide release mechanism. Astrocyte Ca(2+)increase is specifically triggered by the autoreactive CD4(+)T-cell application and these two cell types exhibit close spatial interaction in EAE. Therefore, Ca(2+)signals may mediate a rapid astroglial response to the autoreactive immune cells in their local environment. This property of immune cell-astrocyte interaction may be important to consider in studies interrogating CNS autoimmune disease.",
publisher = "Wiley, Hoboken",
journal = "Journal of Neuroscience Research",
title = "Central nervous system-infiltrated immune cells induce calcium increase in astrocytes via astroglial purinergic signaling",
pages = "2332-2317",
number = "11",
volume = "98",
doi = "10.1002/jnr.24699"
}

Bijelic, D. D., Milicević, K., Lazarević, M. N., Miljković, Đ., Bogdanović Pristov, J., Savić, D. Z., Petković, B., Andjus, P. R., Momcilović, M.,& Nikolić, L. M.. (2020). Central nervous system-infiltrated immune cells induce calcium increase in astrocytes via astroglial purinergic signaling. in Journal of Neuroscience Research
Wiley, Hoboken., 98(11), 2317-2332.
https://doi.org/10.1002/jnr.24699

Bijelic DD, Milicević K, Lazarević MN, Miljković Đ, Bogdanović Pristov J, Savić DZ, Petković B, Andjus PR, Momcilović M, Nikolić LM. Central nervous system-infiltrated immune cells induce calcium increase in astrocytes via astroglial purinergic signaling. in Journal of Neuroscience Research. 2020;98(11):2317-2332.
doi:10.1002/jnr.24699 .

Bijelic, Dunja D., Milicević, Katarina, Lazarević, Milica N., Miljković, Đorđe, Bogdanović Pristov, Jelena, Savić, Danijela Z, Petković, Branka, Andjus, Pavle R., Momcilović, Miljana, Nikolić, Ljiljana M., "Central nervous system-infiltrated immune cells induce calcium increase in astrocytes via astroglial purinergic signaling" in Journal of Neuroscience Research, 98, no. 11 (2020):2317-2332,
https://doi.org/10.1002/jnr.24699 . .

TY  - JOUR
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Podgorac, Jelena
AU  - Spasić, Slađana
AU  - Petković, Branka
AU  - Sekulic, Slobodan
AU  - Kesic, Srdjan
PY  - 2020
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1386
AB  - A detailed analysis of the anesthetic-induced modulation of intracerebellar electrical activity is an important step to understand the functional brain responses to anesthesia. We examined the electrical activity recorded from different cortical layers: molecular layer (ML), Purkinje cell layer (PCL), granular layer (GL) and the white matter (WM) in the vermian part of rat cerebellar lobule V during Nembutal anesthesia using spectral and fractal analysis. Spectral analysis revealed a difference in the mean relative power of delta (0.1-4.0 Hz) and theta (4.1-8.0 Hz) frequencies through the cerebellar layers. Compared to the ML, delta activity increased significantly in the GL, while theta activity decreased in the GL and the WM. Fractal analysis revealed that the mean value of Higuchi's fractal dimension (HFD) increased, starting from the ML to the WM. Theta activity exhibited a negative correlation with the HFD value in the ML. In contrast, the gamma activity showed a positive correlation with the HFD value in the ML and the GL. The combined use of spectral and fractal analyses revealed that Nembutal displays different effects on rat cerebellar electrical activity, which largely depends on the neurochemical and electrophysiological organization of the cerebellar layers.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis
EP  - 432
IS  - 3
SP  - 425
VL  - 72
DO  - 10.2298/ABS200524036S
ER  - 

@article{
author = "Stojadinović, Gordana and Martać, Ljiljana and Podgorac, Jelena and Spasić, Slađana and Petković, Branka and Sekulic, Slobodan and Kesic, Srdjan",
year = "2020",
abstract = "A detailed analysis of the anesthetic-induced modulation of intracerebellar electrical activity is an important step to understand the functional brain responses to anesthesia. We examined the electrical activity recorded from different cortical layers: molecular layer (ML), Purkinje cell layer (PCL), granular layer (GL) and the white matter (WM) in the vermian part of rat cerebellar lobule V during Nembutal anesthesia using spectral and fractal analysis. Spectral analysis revealed a difference in the mean relative power of delta (0.1-4.0 Hz) and theta (4.1-8.0 Hz) frequencies through the cerebellar layers. Compared to the ML, delta activity increased significantly in the GL, while theta activity decreased in the GL and the WM. Fractal analysis revealed that the mean value of Higuchi's fractal dimension (HFD) increased, starting from the ML to the WM. Theta activity exhibited a negative correlation with the HFD value in the ML. In contrast, the gamma activity showed a positive correlation with the HFD value in the ML and the GL. The combined use of spectral and fractal analyses revealed that Nembutal displays different effects on rat cerebellar electrical activity, which largely depends on the neurochemical and electrophysiological organization of the cerebellar layers.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis",
pages = "432-425",
number = "3",
volume = "72",
doi = "10.2298/ABS200524036S"
}

Stojadinović, G., Martać, L., Podgorac, J., Spasić, S., Petković, B., Sekulic, S.,& Kesic, S.. (2020). The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 72(3), 425-432.
https://doi.org/10.2298/ABS200524036S

Stojadinović G, Martać L, Podgorac J, Spasić S, Petković B, Sekulic S, Kesic S. The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis. in Archives of Biological Sciences. 2020;72(3):425-432.
doi:10.2298/ABS200524036S .

Stojadinović, Gordana, Martać, Ljiljana, Podgorac, Jelena, Spasić, Slađana, Petković, Branka, Sekulic, Slobodan, Kesic, Srdjan, "The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis" in Archives of Biological Sciences, 72, no. 3 (2020):425-432,
https://doi.org/10.2298/ABS200524036S . .

TY  - JOUR
AU  - Spasić, Slađana
AU  - Kesic, Srdjan
AU  - Stojadinović, Gordana
AU  - Petković, Branka
AU  - Todorović, Dajana
PY  - 2015
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/830
AB  - To study the influence of a static magnetic field (SMF, 2 mT) and extremely low frequency magnetic field (ELF MF, 50 Hz, 2 mT) on the neuronal population activity, the experiments were performed on adult longhorn beetles Morimus funereus (Coleoptera, Cerambycidae). Based on a wavelet analysis of the local field potentials (LFPs), our study showed for the first time that the effects of prolonged and repeated exposure to the ELF MF on the LFPs were irreversible within investigated time frame. The relative wavelet energy (RWE) of 4-8 Hz frequency band was significantly increased after sine ELF MF (SnMF)/square ELF MF (SqMF) in comparison to the control value. The RWE of slower oscillations (1-2 Hz) was significantly decreased after the repeated exposures to either SnMF or SqMF. The SqMF induced decreasing of the faster waves in the range of 64-128 Hz. However, we did not prove with presented methods that exposure to the SMF for 5 min produces any effects on the neuronal population activity. This study has proved the wavelet transform as a valuable tool for measuring the effects of SMF and ELF MF on the neuronal population activity in M. funereus antennal lobe.
PB  - Elsevier Science Inc, New York
T2  - Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology
T1  - Effects of the static and ELF magnetic fields on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe revealed by wavelet analysis
EP  - 35
SP  - 27
VL  - 181
DO  - 10.1016/j.cbpa.2014.11.018
ER  - 

@article{
author = "Spasić, Slađana and Kesic, Srdjan and Stojadinović, Gordana and Petković, Branka and Todorović, Dajana",
year = "2015",
abstract = "To study the influence of a static magnetic field (SMF, 2 mT) and extremely low frequency magnetic field (ELF MF, 50 Hz, 2 mT) on the neuronal population activity, the experiments were performed on adult longhorn beetles Morimus funereus (Coleoptera, Cerambycidae). Based on a wavelet analysis of the local field potentials (LFPs), our study showed for the first time that the effects of prolonged and repeated exposure to the ELF MF on the LFPs were irreversible within investigated time frame. The relative wavelet energy (RWE) of 4-8 Hz frequency band was significantly increased after sine ELF MF (SnMF)/square ELF MF (SqMF) in comparison to the control value. The RWE of slower oscillations (1-2 Hz) was significantly decreased after the repeated exposures to either SnMF or SqMF. The SqMF induced decreasing of the faster waves in the range of 64-128 Hz. However, we did not prove with presented methods that exposure to the SMF for 5 min produces any effects on the neuronal population activity. This study has proved the wavelet transform as a valuable tool for measuring the effects of SMF and ELF MF on the neuronal population activity in M. funereus antennal lobe.",
publisher = "Elsevier Science Inc, New York",
journal = "Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology",
title = "Effects of the static and ELF magnetic fields on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe revealed by wavelet analysis",
pages = "35-27",
volume = "181",
doi = "10.1016/j.cbpa.2014.11.018"
}

Spasić, S., Kesic, S., Stojadinović, G., Petković, B.,& Todorović, D.. (2015). Effects of the static and ELF magnetic fields on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe revealed by wavelet analysis. in Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology
Elsevier Science Inc, New York., 181, 27-35.
https://doi.org/10.1016/j.cbpa.2014.11.018

Spasić S, Kesic S, Stojadinović G, Petković B, Todorović D. Effects of the static and ELF magnetic fields on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe revealed by wavelet analysis. in Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology. 2015;181:27-35.
doi:10.1016/j.cbpa.2014.11.018 .

Spasić, Slađana, Kesic, Srdjan, Stojadinović, Gordana, Petković, Branka, Todorović, Dajana, "Effects of the static and ELF magnetic fields on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe revealed by wavelet analysis" in Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology, 181 (2015):27-35,
https://doi.org/10.1016/j.cbpa.2014.11.018 . .

TY  - CONF
AU  - Kesić, Srđan Ž.
AU  - Spasić, Slađana
AU  - Stojadinović, Gordana
AU  - Petković, Branka
AU  - Todorović, Dajana
PY  - 2014
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/2388
PB  - Belgrade: Serbian Physiological Society
C3  - 3rd Congress of Physiological Sciences of Serbia With International Participation
T1  - Relative wavelet energy as a measure of the magnetic fields effects on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe
UR  - https://hdl.handle.net/21.15107/rcub_rimsi_2388
ER  - 

@conference{
author = "Kesić, Srđan Ž. and Spasić, Slađana and Stojadinović, Gordana and Petković, Branka and Todorović, Dajana",
year = "2014",
publisher = "Belgrade: Serbian Physiological Society",
journal = "3rd Congress of Physiological Sciences of Serbia With International Participation",
title = "Relative wavelet energy as a measure of the magnetic fields effects on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe",
url = "https://hdl.handle.net/21.15107/rcub_rimsi_2388"
}

Kesić, S. Ž., Spasić, S., Stojadinović, G., Petković, B.,& Todorović, D.. (2014). Relative wavelet energy as a measure of the magnetic fields effects on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe. in 3rd Congress of Physiological Sciences of Serbia With International Participation
Belgrade: Serbian Physiological Society..
https://hdl.handle.net/21.15107/rcub_rimsi_2388

Kesić SŽ, Spasić S, Stojadinović G, Petković B, Todorović D. Relative wavelet energy as a measure of the magnetic fields effects on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe. in 3rd Congress of Physiological Sciences of Serbia With International Participation. 2014;.
https://hdl.handle.net/21.15107/rcub_rimsi_2388 .

Kesić, Srđan Ž., Spasić, Slađana, Stojadinović, Gordana, Petković, Branka, Todorović, Dajana, "Relative wavelet energy as a measure of the magnetic fields effects on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe" in 3rd Congress of Physiological Sciences of Serbia With International Participation (2014),
https://hdl.handle.net/21.15107/rcub_rimsi_2388 .

TY  - JOUR
AU  - Kesic, Srdjan
AU  - Nikolić, Ljiljana M.
AU  - Savić, Aleksandar G
AU  - Petković, Branka
AU  - Spasić, Slađana
PY  - 2014
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/786
AB  - Aim of this study was to investigate the application of normalized mean of the empirical Higuchi fractal dimension (FD) distributions, as a new approach to analyze the spontaneous bioelectrical activity of garden snail (Helix pomatia) Br neuron. The effect of ouabain on modulation of Br neuron bursting activity before and after the exposure to 10 mT static magnetic field (SMF) was observed by analyzing the following parameters: action potential (AP), interspike interval (ISI) and interbursting interval (IBI) components. Normalized mean of the empirical FD distributions were formed for the following experimental conditions: Control 1, Ouabain 1, Control 2, SMF 2, ASMF 2, Control 3, SMF 3 and Ouabain ASMF 3. Our main results have shown that ouabain without SMF induced increase in participation of AP and a decrease in participation of IBI components compared to the first control condition. However, in the presence of 10 mT SMF, ouabain-induced changes of measured parameters of Br neuron activity were less pronounced compared to the third control condition. We have shown that normalized mean of the empirical FD distributions is a useful method for detecting the changes in AP, ISI, and IBI components of complex bursting activity in altered physiological states.
PB  - General Physiol And Biophysics, Bratislava
T2  - General Physiology and Biophysics
T1  - Ouabain modulation of snail Br neuron bursting activity after the exposure to 10 mT static magnetic field revealed by Higuchi fractal dimension
EP  - 344
IS  - 3
SP  - 335
VL  - 33
DO  - 10.4149/gpb_2014010
ER  - 

@article{
author = "Kesic, Srdjan and Nikolić, Ljiljana M. and Savić, Aleksandar G and Petković, Branka and Spasić, Slađana",
year = "2014",
abstract = "Aim of this study was to investigate the application of normalized mean of the empirical Higuchi fractal dimension (FD) distributions, as a new approach to analyze the spontaneous bioelectrical activity of garden snail (Helix pomatia) Br neuron. The effect of ouabain on modulation of Br neuron bursting activity before and after the exposure to 10 mT static magnetic field (SMF) was observed by analyzing the following parameters: action potential (AP), interspike interval (ISI) and interbursting interval (IBI) components. Normalized mean of the empirical FD distributions were formed for the following experimental conditions: Control 1, Ouabain 1, Control 2, SMF 2, ASMF 2, Control 3, SMF 3 and Ouabain ASMF 3. Our main results have shown that ouabain without SMF induced increase in participation of AP and a decrease in participation of IBI components compared to the first control condition. However, in the presence of 10 mT SMF, ouabain-induced changes of measured parameters of Br neuron activity were less pronounced compared to the third control condition. We have shown that normalized mean of the empirical FD distributions is a useful method for detecting the changes in AP, ISI, and IBI components of complex bursting activity in altered physiological states.",
publisher = "General Physiol And Biophysics, Bratislava",
journal = "General Physiology and Biophysics",
title = "Ouabain modulation of snail Br neuron bursting activity after the exposure to 10 mT static magnetic field revealed by Higuchi fractal dimension",
pages = "344-335",
number = "3",
volume = "33",
doi = "10.4149/gpb_2014010"
}

Kesic, S., Nikolić, L. M., Savić, A. G., Petković, B.,& Spasić, S.. (2014). Ouabain modulation of snail Br neuron bursting activity after the exposure to 10 mT static magnetic field revealed by Higuchi fractal dimension. in General Physiology and Biophysics
General Physiol And Biophysics, Bratislava., 33(3), 335-344.
https://doi.org/10.4149/gpb_2014010

Kesic S, Nikolić LM, Savić AG, Petković B, Spasić S. Ouabain modulation of snail Br neuron bursting activity after the exposure to 10 mT static magnetic field revealed by Higuchi fractal dimension. in General Physiology and Biophysics. 2014;33(3):335-344.
doi:10.4149/gpb_2014010 .

Kesic, Srdjan, Nikolić, Ljiljana M., Savić, Aleksandar G, Petković, Branka, Spasić, Slađana, "Ouabain modulation of snail Br neuron bursting activity after the exposure to 10 mT static magnetic field revealed by Higuchi fractal dimension" in General Physiology and Biophysics, 33, no. 3 (2014):335-344,
https://doi.org/10.4149/gpb_2014010 . .

TY  - JOUR
AU  - Kesic, S.
AU  - Nikolić, Ljiljana M.
AU  - Janac, Branka
AU  - Spasić, Slađana
PY  - 2014
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/767
AB  - The components of complex bioelectrical activity - action potential (AP), interspike interval (ISI) and the quiet interburst interval (IBI), along with the effects of 2.7 mT and 10 mT static magnetic fields, were identified and examined in the spontaneously active Br neuron of the subesophageal ganglion complex of the garden snail Helix pomatia by fractal analysis using Higuchi's fractal dimension (FD). The normalized mean of the empirical FD distributions of bursting activity of the Br neuron were formed under different experimental conditions: before (Control), during (MF), and after exposure to the static magnetic field (AMF). Using the fractal analysis method for the first time, a separation of the AP, ISI and IBI components was successfully achieved. Our results show that fractal analysis with deconvolution of the normalized mean of the empirical FD distributions into Gaussian functions is a useful tool for revealing the effects of magnetic fields on the complexity of neuronal bioelectric activity and its AP, ISI and IBI components.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - Using Higuchi’s fractal dimension in fine analysis of the effects of 2.7 mt and 10 mt static magnetic fields on the complex bursting activity of the snail br neuron
EP  - 572
IS  - 2
SP  - 563
VL  - 66
DO  - 10.2298/ABS1402563K
ER  - 

@article{
author = "Kesic, S. and Nikolić, Ljiljana M. and Janac, Branka and Spasić, Slađana",
year = "2014",
abstract = "The components of complex bioelectrical activity - action potential (AP), interspike interval (ISI) and the quiet interburst interval (IBI), along with the effects of 2.7 mT and 10 mT static magnetic fields, were identified and examined in the spontaneously active Br neuron of the subesophageal ganglion complex of the garden snail Helix pomatia by fractal analysis using Higuchi's fractal dimension (FD). The normalized mean of the empirical FD distributions of bursting activity of the Br neuron were formed under different experimental conditions: before (Control), during (MF), and after exposure to the static magnetic field (AMF). Using the fractal analysis method for the first time, a separation of the AP, ISI and IBI components was successfully achieved. Our results show that fractal analysis with deconvolution of the normalized mean of the empirical FD distributions into Gaussian functions is a useful tool for revealing the effects of magnetic fields on the complexity of neuronal bioelectric activity and its AP, ISI and IBI components.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Using Higuchi’s fractal dimension in fine analysis of the effects of 2.7 mt and 10 mt static magnetic fields on the complex bursting activity of the snail br neuron",
pages = "572-563",
number = "2",
volume = "66",
doi = "10.2298/ABS1402563K"
}

Kesic, S., Nikolić, L. M., Janac, B.,& Spasić, S.. (2014). Using Higuchi’s fractal dimension in fine analysis of the effects of 2.7 mt and 10 mt static magnetic fields on the complex bursting activity of the snail br neuron. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 66(2), 563-572.
https://doi.org/10.2298/ABS1402563K

Kesic S, Nikolić LM, Janac B, Spasić S. Using Higuchi’s fractal dimension in fine analysis of the effects of 2.7 mt and 10 mt static magnetic fields on the complex bursting activity of the snail br neuron. in Archives of Biological Sciences. 2014;66(2):563-572.
doi:10.2298/ABS1402563K .

Kesic, S., Nikolić, Ljiljana M., Janac, Branka, Spasić, Slađana, "Using Higuchi’s fractal dimension in fine analysis of the effects of 2.7 mt and 10 mt static magnetic fields on the complex bursting activity of the snail br neuron" in Archives of Biological Sciences, 66, no. 2 (2014):563-572,
https://doi.org/10.2298/ABS1402563K . .

TY  - JOUR
AU  - Nikolić, Ljiljana M.
AU  - Todorović, Nataša
AU  - Zakrzewska, Joanna
AU  - Stanić, Marina
AU  - Raus, Snežana Z
AU  - Kalauzi, Aleksandar
AU  - Janac, Branka B
PY  - 2012
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/539
AB  - The spontaneously active Br neuron from the brain-subesophageal ganglion complex of the garden snail Helix pomatia rhythmically generates regular bursts of action potentials with quiescent intervals accompanied by slow oscillations of membrane potential. We examined the involvement of the Na+/K+ pump in modulating its bursting activity by applying a static magnetic field. Whole snail brains and Br neuron were exposed to the 10-mT static magnetic field for 15 min. Biochemical data showed that Na+/K+-ATPase activity increased almost twofold after exposure of snail brains to the static magnetic field. Similarly, P-31 NMR data revealed a trend of increasing ATP consumption and increase in intracellular pH mediated by the Na+/H+ exchanger in snail brains exposed to the static magnetic field. Importantly, current clamp recordings from the Br neuron confirmed the increase in activity of the Na+/K+ pump after exposure to the static magnetic field, as the magnitude of ouabain's effect measured on the membrane resting potential, action potential, and interspike interval duration was higher in neurons exposed to the magnetic field. Metabolic pathways through which the magnetic field influenced the Na+/K+ pump could involve phosphorylation and dephosphorylation, as blocking these processes abolished the effect of the static magnetic field.
PB  - Springer, New York
T2  - Journal of Comparative Physiology A-Neuroethology Sensory Neural and Behavioral Physiology
T1  - Involvement of Na+/K(+)pump in fine modulation of bursting activity of the snail Br neuron by 10 mT static magnetic field
EP  - 540
IS  - 7
SP  - 525
VL  - 198
DO  - 10.1007/s00359-012-0727-0
ER  - 

@article{
author = "Nikolić, Ljiljana M. and Todorović, Nataša and Zakrzewska, Joanna and Stanić, Marina and Raus, Snežana Z and Kalauzi, Aleksandar and Janac, Branka B",
year = "2012",
abstract = "The spontaneously active Br neuron from the brain-subesophageal ganglion complex of the garden snail Helix pomatia rhythmically generates regular bursts of action potentials with quiescent intervals accompanied by slow oscillations of membrane potential. We examined the involvement of the Na+/K+ pump in modulating its bursting activity by applying a static magnetic field. Whole snail brains and Br neuron were exposed to the 10-mT static magnetic field for 15 min. Biochemical data showed that Na+/K+-ATPase activity increased almost twofold after exposure of snail brains to the static magnetic field. Similarly, P-31 NMR data revealed a trend of increasing ATP consumption and increase in intracellular pH mediated by the Na+/H+ exchanger in snail brains exposed to the static magnetic field. Importantly, current clamp recordings from the Br neuron confirmed the increase in activity of the Na+/K+ pump after exposure to the static magnetic field, as the magnitude of ouabain's effect measured on the membrane resting potential, action potential, and interspike interval duration was higher in neurons exposed to the magnetic field. Metabolic pathways through which the magnetic field influenced the Na+/K+ pump could involve phosphorylation and dephosphorylation, as blocking these processes abolished the effect of the static magnetic field.",
publisher = "Springer, New York",
journal = "Journal of Comparative Physiology A-Neuroethology Sensory Neural and Behavioral Physiology",
title = "Involvement of Na+/K(+)pump in fine modulation of bursting activity of the snail Br neuron by 10 mT static magnetic field",
pages = "540-525",
number = "7",
volume = "198",
doi = "10.1007/s00359-012-0727-0"
}

Nikolić, L. M., Todorović, N., Zakrzewska, J., Stanić, M., Raus, S. Z., Kalauzi, A.,& Janac, B. B.. (2012). Involvement of Na+/K(+)pump in fine modulation of bursting activity of the snail Br neuron by 10 mT static magnetic field. in Journal of Comparative Physiology A-Neuroethology Sensory Neural and Behavioral Physiology
Springer, New York., 198(7), 525-540.
https://doi.org/10.1007/s00359-012-0727-0

Nikolić LM, Todorović N, Zakrzewska J, Stanić M, Raus SZ, Kalauzi A, Janac BB. Involvement of Na+/K(+)pump in fine modulation of bursting activity of the snail Br neuron by 10 mT static magnetic field. in Journal of Comparative Physiology A-Neuroethology Sensory Neural and Behavioral Physiology. 2012;198(7):525-540.
doi:10.1007/s00359-012-0727-0 .

Nikolić, Ljiljana M., Todorović, Nataša, Zakrzewska, Joanna, Stanić, Marina, Raus, Snežana Z, Kalauzi, Aleksandar, Janac, Branka B, "Involvement of Na+/K(+)pump in fine modulation of bursting activity of the snail Br neuron by 10 mT static magnetic field" in Journal of Comparative Physiology A-Neuroethology Sensory Neural and Behavioral Physiology, 198, no. 7 (2012):525-540,
https://doi.org/10.1007/s00359-012-0727-0 . .