TY  - JOUR
AU  - Stojadinović, Gordana
AU  - Martać, Ljiljana
AU  - Podgorac, Jelena
AU  - Spasić, Slađana
AU  - Petković, Branka
AU  - Sekulic, Slobodan
AU  - Kesic, Srdjan
PY  - 2020
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1386
AB  - A detailed analysis of the anesthetic-induced modulation of intracerebellar electrical activity is an important step to understand the functional brain responses to anesthesia. We examined the electrical activity recorded from different cortical layers: molecular layer (ML), Purkinje cell layer (PCL), granular layer (GL) and the white matter (WM) in the vermian part of rat cerebellar lobule V during Nembutal anesthesia using spectral and fractal analysis. Spectral analysis revealed a difference in the mean relative power of delta (0.1-4.0 Hz) and theta (4.1-8.0 Hz) frequencies through the cerebellar layers. Compared to the ML, delta activity increased significantly in the GL, while theta activity decreased in the GL and the WM. Fractal analysis revealed that the mean value of Higuchi's fractal dimension (HFD) increased, starting from the ML to the WM. Theta activity exhibited a negative correlation with the HFD value in the ML. In contrast, the gamma activity showed a positive correlation with the HFD value in the ML and the GL. The combined use of spectral and fractal analyses revealed that Nembutal displays different effects on rat cerebellar electrical activity, which largely depends on the neurochemical and electrophysiological organization of the cerebellar layers.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis
EP  - 432
IS  - 3
SP  - 425
VL  - 72
DO  - 10.2298/ABS200524036S
ER  - 

@article{
author = "Stojadinović, Gordana and Martać, Ljiljana and Podgorac, Jelena and Spasić, Slađana and Petković, Branka and Sekulic, Slobodan and Kesic, Srdjan",
year = "2020",
abstract = "A detailed analysis of the anesthetic-induced modulation of intracerebellar electrical activity is an important step to understand the functional brain responses to anesthesia. We examined the electrical activity recorded from different cortical layers: molecular layer (ML), Purkinje cell layer (PCL), granular layer (GL) and the white matter (WM) in the vermian part of rat cerebellar lobule V during Nembutal anesthesia using spectral and fractal analysis. Spectral analysis revealed a difference in the mean relative power of delta (0.1-4.0 Hz) and theta (4.1-8.0 Hz) frequencies through the cerebellar layers. Compared to the ML, delta activity increased significantly in the GL, while theta activity decreased in the GL and the WM. Fractal analysis revealed that the mean value of Higuchi's fractal dimension (HFD) increased, starting from the ML to the WM. Theta activity exhibited a negative correlation with the HFD value in the ML. In contrast, the gamma activity showed a positive correlation with the HFD value in the ML and the GL. The combined use of spectral and fractal analyses revealed that Nembutal displays different effects on rat cerebellar electrical activity, which largely depends on the neurochemical and electrophysiological organization of the cerebellar layers.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis",
pages = "432-425",
number = "3",
volume = "72",
doi = "10.2298/ABS200524036S"
}

Stojadinović, G., Martać, L., Podgorac, J., Spasić, S., Petković, B., Sekulic, S.,& Kesic, S.. (2020). The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 72(3), 425-432.
https://doi.org/10.2298/ABS200524036S

Stojadinović G, Martać L, Podgorac J, Spasić S, Petković B, Sekulic S, Kesic S. The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis. in Archives of Biological Sciences. 2020;72(3):425-432.
doi:10.2298/ABS200524036S .

Stojadinović, Gordana, Martać, Ljiljana, Podgorac, Jelena, Spasić, Slađana, Petković, Branka, Sekulic, Slobodan, Kesic, Srdjan, "The effects of Nembutal on the intracerebellar EEG activity revealed by spectral and fractal analysis" in Archives of Biological Sciences, 72, no. 3 (2020):425-432,
https://doi.org/10.2298/ABS200524036S . .

Spasić, S.,& Kesic, S.. (2019). Editorial: Nonlinearity in Living Systems: Theoretical and Practical Perspectives on Metrics of Physiological Signal Complexity. in Frontiers in Physiology
Frontiers Media Sa, Lausanne., 10.
https://doi.org/10.3389/fphys.2019.00298

Spasić S, Kesic S. Editorial: Nonlinearity in Living Systems: Theoretical and Practical Perspectives on Metrics of Physiological Signal Complexity. in Frontiers in Physiology. 2019;10.
doi:10.3389/fphys.2019.00298 .

Spasić, Slađana, Kesic, Srdjan, "Editorial: Nonlinearity in Living Systems: Theoretical and Practical Perspectives on Metrics of Physiological Signal Complexity" in Frontiers in Physiology, 10 (2019),
https://doi.org/10.3389/fphys.2019.00298 . .

TY  - JOUR
AU  - Kesic, Srdjan
AU  - Spasić, Slađana
PY  - 2016
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1006
AB  - Background and objective: For more than 20 years, Higuchi's fractal dimension (HFD), as a nonlinear method, has occupied an important place in the analysis of biological signals. The use of HFD has evolved from EEG and single neuron activity analysis to the most recent application in automated assessments of different clinical conditions. Our objective is to provide an updated review of the HFD method applied in basic and clinical neurophysiological research. Methods: This article summarizes and critically reviews a broad literature and major findings concerning the applications of HFD for measuring the complexity of neuronal activity during different neurophysiological conditions. The source of information used in this review comes from the PubMed, Scopus, Google Scholar and IEEE Xplore Digital Library databases. Results: The review process substantiated the significance, advantages and shortcomings of HFD application within all key areas of basic and clinical neurophysiology. Therefore, the paper discusses HFD application alone, combined with other linear or nonlinear measures, or as a part of automated methods for analyzing neurophysiological signals. Conclusions: The speed, accuracy and cost of applying the HFD method for research and medical diagnosis make it stand out from the widely used linear methods. However, only a combination of HFD with other nonlinear methods ensures reliable and accurate analysis of a wide range of neurophysiological signals.
PB  - Elsevier Ireland Ltd, Clare
T2  - Computer Methods and Programs in Biomedicine
T1  - Application of Higuchi's fractal dimension from basic to clinical neurophysiology: A review
EP  - 70
SP  - 55
VL  - 133
DO  - 10.1016/j.cmpb.2016.05.014
ER  - 

@article{
author = "Kesic, Srdjan and Spasić, Slađana",
year = "2016",
abstract = "Background and objective: For more than 20 years, Higuchi's fractal dimension (HFD), as a nonlinear method, has occupied an important place in the analysis of biological signals. The use of HFD has evolved from EEG and single neuron activity analysis to the most recent application in automated assessments of different clinical conditions. Our objective is to provide an updated review of the HFD method applied in basic and clinical neurophysiological research. Methods: This article summarizes and critically reviews a broad literature and major findings concerning the applications of HFD for measuring the complexity of neuronal activity during different neurophysiological conditions. The source of information used in this review comes from the PubMed, Scopus, Google Scholar and IEEE Xplore Digital Library databases. Results: The review process substantiated the significance, advantages and shortcomings of HFD application within all key areas of basic and clinical neurophysiology. Therefore, the paper discusses HFD application alone, combined with other linear or nonlinear measures, or as a part of automated methods for analyzing neurophysiological signals. Conclusions: The speed, accuracy and cost of applying the HFD method for research and medical diagnosis make it stand out from the widely used linear methods. However, only a combination of HFD with other nonlinear methods ensures reliable and accurate analysis of a wide range of neurophysiological signals.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Computer Methods and Programs in Biomedicine",
title = "Application of Higuchi's fractal dimension from basic to clinical neurophysiology: A review",
pages = "70-55",
volume = "133",
doi = "10.1016/j.cmpb.2016.05.014"
}

Kesic, S.,& Spasić, S.. (2016). Application of Higuchi's fractal dimension from basic to clinical neurophysiology: A review. in Computer Methods and Programs in Biomedicine
Elsevier Ireland Ltd, Clare., 133, 55-70.
https://doi.org/10.1016/j.cmpb.2016.05.014

Kesic S, Spasić S. Application of Higuchi's fractal dimension from basic to clinical neurophysiology: A review. in Computer Methods and Programs in Biomedicine. 2016;133:55-70.
doi:10.1016/j.cmpb.2016.05.014 .

Kesic, Srdjan, Spasić, Slađana, "Application of Higuchi's fractal dimension from basic to clinical neurophysiology: A review" in Computer Methods and Programs in Biomedicine, 133 (2016):55-70,
https://doi.org/10.1016/j.cmpb.2016.05.014 . .

TY  - JOUR
AU  - Spasić, Slađana
AU  - Kesic, Srdjan
AU  - Stojadinović, Gordana
AU  - Petković, Branka
AU  - Todorović, Dajana
PY  - 2015
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/830
AB  - To study the influence of a static magnetic field (SMF, 2 mT) and extremely low frequency magnetic field (ELF MF, 50 Hz, 2 mT) on the neuronal population activity, the experiments were performed on adult longhorn beetles Morimus funereus (Coleoptera, Cerambycidae). Based on a wavelet analysis of the local field potentials (LFPs), our study showed for the first time that the effects of prolonged and repeated exposure to the ELF MF on the LFPs were irreversible within investigated time frame. The relative wavelet energy (RWE) of 4-8 Hz frequency band was significantly increased after sine ELF MF (SnMF)/square ELF MF (SqMF) in comparison to the control value. The RWE of slower oscillations (1-2 Hz) was significantly decreased after the repeated exposures to either SnMF or SqMF. The SqMF induced decreasing of the faster waves in the range of 64-128 Hz. However, we did not prove with presented methods that exposure to the SMF for 5 min produces any effects on the neuronal population activity. This study has proved the wavelet transform as a valuable tool for measuring the effects of SMF and ELF MF on the neuronal population activity in M. funereus antennal lobe.
PB  - Elsevier Science Inc, New York
T2  - Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology
T1  - Effects of the static and ELF magnetic fields on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe revealed by wavelet analysis
EP  - 35
SP  - 27
VL  - 181
DO  - 10.1016/j.cbpa.2014.11.018
ER  - 

@article{
author = "Spasić, Slađana and Kesic, Srdjan and Stojadinović, Gordana and Petković, Branka and Todorović, Dajana",
year = "2015",
abstract = "To study the influence of a static magnetic field (SMF, 2 mT) and extremely low frequency magnetic field (ELF MF, 50 Hz, 2 mT) on the neuronal population activity, the experiments were performed on adult longhorn beetles Morimus funereus (Coleoptera, Cerambycidae). Based on a wavelet analysis of the local field potentials (LFPs), our study showed for the first time that the effects of prolonged and repeated exposure to the ELF MF on the LFPs were irreversible within investigated time frame. The relative wavelet energy (RWE) of 4-8 Hz frequency band was significantly increased after sine ELF MF (SnMF)/square ELF MF (SqMF) in comparison to the control value. The RWE of slower oscillations (1-2 Hz) was significantly decreased after the repeated exposures to either SnMF or SqMF. The SqMF induced decreasing of the faster waves in the range of 64-128 Hz. However, we did not prove with presented methods that exposure to the SMF for 5 min produces any effects on the neuronal population activity. This study has proved the wavelet transform as a valuable tool for measuring the effects of SMF and ELF MF on the neuronal population activity in M. funereus antennal lobe.",
publisher = "Elsevier Science Inc, New York",
journal = "Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology",
title = "Effects of the static and ELF magnetic fields on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe revealed by wavelet analysis",
pages = "35-27",
volume = "181",
doi = "10.1016/j.cbpa.2014.11.018"
}

Spasić, S., Kesic, S., Stojadinović, G., Petković, B.,& Todorović, D.. (2015). Effects of the static and ELF magnetic fields on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe revealed by wavelet analysis. in Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology
Elsevier Science Inc, New York., 181, 27-35.
https://doi.org/10.1016/j.cbpa.2014.11.018

Spasić S, Kesic S, Stojadinović G, Petković B, Todorović D. Effects of the static and ELF magnetic fields on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe revealed by wavelet analysis. in Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology. 2015;181:27-35.
doi:10.1016/j.cbpa.2014.11.018 .

Spasić, Slađana, Kesic, Srdjan, Stojadinović, Gordana, Petković, Branka, Todorović, Dajana, "Effects of the static and ELF magnetic fields on the neuronal population activity in Morimus funereus (Coleoptera, Cerambycidae) antennal lobe revealed by wavelet analysis" in Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology, 181 (2015):27-35,
https://doi.org/10.1016/j.cbpa.2014.11.018 . .

TY  - JOUR
AU  - Kesic, Srdjan
AU  - Nikolić, Ljiljana M.
AU  - Savić, Aleksandar G
AU  - Petković, Branka
AU  - Spasić, Slađana
PY  - 2014
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/786
AB  - Aim of this study was to investigate the application of normalized mean of the empirical Higuchi fractal dimension (FD) distributions, as a new approach to analyze the spontaneous bioelectrical activity of garden snail (Helix pomatia) Br neuron. The effect of ouabain on modulation of Br neuron bursting activity before and after the exposure to 10 mT static magnetic field (SMF) was observed by analyzing the following parameters: action potential (AP), interspike interval (ISI) and interbursting interval (IBI) components. Normalized mean of the empirical FD distributions were formed for the following experimental conditions: Control 1, Ouabain 1, Control 2, SMF 2, ASMF 2, Control 3, SMF 3 and Ouabain ASMF 3. Our main results have shown that ouabain without SMF induced increase in participation of AP and a decrease in participation of IBI components compared to the first control condition. However, in the presence of 10 mT SMF, ouabain-induced changes of measured parameters of Br neuron activity were less pronounced compared to the third control condition. We have shown that normalized mean of the empirical FD distributions is a useful method for detecting the changes in AP, ISI, and IBI components of complex bursting activity in altered physiological states.
PB  - General Physiol And Biophysics, Bratislava
T2  - General Physiology and Biophysics
T1  - Ouabain modulation of snail Br neuron bursting activity after the exposure to 10 mT static magnetic field revealed by Higuchi fractal dimension
EP  - 344
IS  - 3
SP  - 335
VL  - 33
DO  - 10.4149/gpb_2014010
ER  - 

@article{
author = "Kesic, Srdjan and Nikolić, Ljiljana M. and Savić, Aleksandar G and Petković, Branka and Spasić, Slađana",
year = "2014",
abstract = "Aim of this study was to investigate the application of normalized mean of the empirical Higuchi fractal dimension (FD) distributions, as a new approach to analyze the spontaneous bioelectrical activity of garden snail (Helix pomatia) Br neuron. The effect of ouabain on modulation of Br neuron bursting activity before and after the exposure to 10 mT static magnetic field (SMF) was observed by analyzing the following parameters: action potential (AP), interspike interval (ISI) and interbursting interval (IBI) components. Normalized mean of the empirical FD distributions were formed for the following experimental conditions: Control 1, Ouabain 1, Control 2, SMF 2, ASMF 2, Control 3, SMF 3 and Ouabain ASMF 3. Our main results have shown that ouabain without SMF induced increase in participation of AP and a decrease in participation of IBI components compared to the first control condition. However, in the presence of 10 mT SMF, ouabain-induced changes of measured parameters of Br neuron activity were less pronounced compared to the third control condition. We have shown that normalized mean of the empirical FD distributions is a useful method for detecting the changes in AP, ISI, and IBI components of complex bursting activity in altered physiological states.",
publisher = "General Physiol And Biophysics, Bratislava",
journal = "General Physiology and Biophysics",
title = "Ouabain modulation of snail Br neuron bursting activity after the exposure to 10 mT static magnetic field revealed by Higuchi fractal dimension",
pages = "344-335",
number = "3",
volume = "33",
doi = "10.4149/gpb_2014010"
}

Kesic, S., Nikolić, L. M., Savić, A. G., Petković, B.,& Spasić, S.. (2014). Ouabain modulation of snail Br neuron bursting activity after the exposure to 10 mT static magnetic field revealed by Higuchi fractal dimension. in General Physiology and Biophysics
General Physiol And Biophysics, Bratislava., 33(3), 335-344.
https://doi.org/10.4149/gpb_2014010

Kesic S, Nikolić LM, Savić AG, Petković B, Spasić S. Ouabain modulation of snail Br neuron bursting activity after the exposure to 10 mT static magnetic field revealed by Higuchi fractal dimension. in General Physiology and Biophysics. 2014;33(3):335-344.
doi:10.4149/gpb_2014010 .

Kesic, Srdjan, Nikolić, Ljiljana M., Savić, Aleksandar G, Petković, Branka, Spasić, Slađana, "Ouabain modulation of snail Br neuron bursting activity after the exposure to 10 mT static magnetic field revealed by Higuchi fractal dimension" in General Physiology and Biophysics, 33, no. 3 (2014):335-344,
https://doi.org/10.4149/gpb_2014010 . .

TY  - JOUR
AU  - Spasić, Slađana
AU  - Kalauzi, Aleksandar
AU  - Kesic, Srdjan
AU  - Obradović, Milica
AU  - Šaponjić, Jasna
PY  - 2011
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/460
AB  - We used spectral analysis and Higuchi fractal dimension (FD) to correlate the EEG spectral characteristics of the sensorimotor cortex, hippocampus, and pons with their corresponding EEG signal complexities in anesthetized rats. We have explored the quantitative relationship between the mean FDs and EEG wide range high frequency (8-50 Hz) activity during ketamine/xylazine versus nembutal anesthesia at surgical plane. Using FD we detected distinct inter-structure complexity pattern and uncovered for the first time that the polygraphically and behaviorally defined anesthetized state at surgical plane as equal during experiment in two anesthetic regimens, is not the same with respect to the degree of neuronal activity (degree of generalized neuronal inhibition achieved) at different brain levels. Using the correlation of certain brain structure EEG spectral characteristics with their corresponding FDs, and the surrogate data modeling, we determined what particular frequency band contributes to EEG complexities in ketamine/xylazine versus nembutal anesthesia. In this study we have shown that the quantitative relationship between higher frequency EEG amplitude and EEG complexity is the best-modeled by surrogate data as a 3rd order polynomial. On the base of our EEG amplitude/EEG complexity relationship model, and the evidenced spectral differences in ketamine versus nembutal anesthesia we have proved that higher amplitudes of sigma, beta, and gamma frequency in ketamine anesthesia yields to higher FDs.
PB  - Academic Press Ltd- Elsevier Science Ltd, London
T2  - Journal of Theoretical Biology
T1  - Surrogate data modeling the relationship between high frequency amplitudes and Higuchi fractal dimension of EEG signals in anesthetized rats
EP  - 166
SP  - 160
VL  - 289
DO  - 10.1016/j.jtbi.2011.08.037
ER  - 

@article{
author = "Spasić, Slađana and Kalauzi, Aleksandar and Kesic, Srdjan and Obradović, Milica and Šaponjić, Jasna",
year = "2011",
abstract = "We used spectral analysis and Higuchi fractal dimension (FD) to correlate the EEG spectral characteristics of the sensorimotor cortex, hippocampus, and pons with their corresponding EEG signal complexities in anesthetized rats. We have explored the quantitative relationship between the mean FDs and EEG wide range high frequency (8-50 Hz) activity during ketamine/xylazine versus nembutal anesthesia at surgical plane. Using FD we detected distinct inter-structure complexity pattern and uncovered for the first time that the polygraphically and behaviorally defined anesthetized state at surgical plane as equal during experiment in two anesthetic regimens, is not the same with respect to the degree of neuronal activity (degree of generalized neuronal inhibition achieved) at different brain levels. Using the correlation of certain brain structure EEG spectral characteristics with their corresponding FDs, and the surrogate data modeling, we determined what particular frequency band contributes to EEG complexities in ketamine/xylazine versus nembutal anesthesia. In this study we have shown that the quantitative relationship between higher frequency EEG amplitude and EEG complexity is the best-modeled by surrogate data as a 3rd order polynomial. On the base of our EEG amplitude/EEG complexity relationship model, and the evidenced spectral differences in ketamine versus nembutal anesthesia we have proved that higher amplitudes of sigma, beta, and gamma frequency in ketamine anesthesia yields to higher FDs.",
publisher = "Academic Press Ltd- Elsevier Science Ltd, London",
journal = "Journal of Theoretical Biology",
title = "Surrogate data modeling the relationship between high frequency amplitudes and Higuchi fractal dimension of EEG signals in anesthetized rats",
pages = "166-160",
volume = "289",
doi = "10.1016/j.jtbi.2011.08.037"
}

Spasić, S., Kalauzi, A., Kesic, S., Obradović, M.,& Šaponjić, J.. (2011). Surrogate data modeling the relationship between high frequency amplitudes and Higuchi fractal dimension of EEG signals in anesthetized rats. in Journal of Theoretical Biology
Academic Press Ltd- Elsevier Science Ltd, London., 289, 160-166.
https://doi.org/10.1016/j.jtbi.2011.08.037

Spasić S, Kalauzi A, Kesic S, Obradović M, Šaponjić J. Surrogate data modeling the relationship between high frequency amplitudes and Higuchi fractal dimension of EEG signals in anesthetized rats. in Journal of Theoretical Biology. 2011;289:160-166.
doi:10.1016/j.jtbi.2011.08.037 .

Spasić, Slađana, Kalauzi, Aleksandar, Kesic, Srdjan, Obradović, Milica, Šaponjić, Jasna, "Surrogate data modeling the relationship between high frequency amplitudes and Higuchi fractal dimension of EEG signals in anesthetized rats" in Journal of Theoretical Biology, 289 (2011):160-166,
https://doi.org/10.1016/j.jtbi.2011.08.037 . .

TY  - JOUR
AU  - Spasić, Slađana
AU  - Kesic, Srdjan
AU  - Kalauzi, Aleksandar
AU  - Šaponjić, Jasna
PY  - 2011
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/443
AB  - The complexity, entropy and other non-linear measures of the electroencephalogram ( EEG), such as Higuchi fractal dimension (FD), have been recently proposed as the measures of anesthesia depth and sedation. We hypothesized that during unconciousness in rats induced by the general anesthetics with opposite mechanism of action, behaviorally and poligraphically controlled as appropriately achieved stable anesthesia, we can detect distinct inter-structure brain dynamic using mean FDs. We used the surrogate data test for nonlinearity in order to establish the existence of nonlinear dynamics, and to justify the use of FD as a nonlinear measure in the time series analysis. The surrogate data of predefined probability distribution and autocorrelation properties have been generated using the algorithm of statically transformed autoregressive process (STAP). FD then is applied to quantify EEG signal complexity at the cortical, hippocampal and pontine level during stable general anesthesia (ketamine/xylazine or nembutal anesthesia). Our study showed for the first time that global neuronal inhibition caused by different mechanisms of anesthetic action induced distinct brain inter- structure complexity gradient in Sprague Dawley rats. EEG signal complexities were higher at cortical and hippocampal level in ketamine/ xylazine vs. nembutal anesthesia, with the dominance of hippocampal complexity. In nembutal anesthesia the complexity dominance moved to pontine level, and ponto- hippocampocortical decreasing complexity gradient was established. This study has proved the Higuchi fractal dimension as a valuable tool for measuring the anesthesia induced inter- structure EEG complexity.
PB  - World Scientific Publ Co Pte Ltd, Singapore
T2  - Fractals-Complex Geometry Patterns and Scaling in Nature and Society
T1  - Different anesthesia in rat induces distinct inter-structure brain dynamic detected by higuchi fractal dimension
EP  - 123
IS  - 1
SP  - 113
VL  - 19
DO  - 10.1142/S0218348X1100521X
ER  - 

@article{
author = "Spasić, Slađana and Kesic, Srdjan and Kalauzi, Aleksandar and Šaponjić, Jasna",
year = "2011",
abstract = "The complexity, entropy and other non-linear measures of the electroencephalogram ( EEG), such as Higuchi fractal dimension (FD), have been recently proposed as the measures of anesthesia depth and sedation. We hypothesized that during unconciousness in rats induced by the general anesthetics with opposite mechanism of action, behaviorally and poligraphically controlled as appropriately achieved stable anesthesia, we can detect distinct inter-structure brain dynamic using mean FDs. We used the surrogate data test for nonlinearity in order to establish the existence of nonlinear dynamics, and to justify the use of FD as a nonlinear measure in the time series analysis. The surrogate data of predefined probability distribution and autocorrelation properties have been generated using the algorithm of statically transformed autoregressive process (STAP). FD then is applied to quantify EEG signal complexity at the cortical, hippocampal and pontine level during stable general anesthesia (ketamine/xylazine or nembutal anesthesia). Our study showed for the first time that global neuronal inhibition caused by different mechanisms of anesthetic action induced distinct brain inter- structure complexity gradient in Sprague Dawley rats. EEG signal complexities were higher at cortical and hippocampal level in ketamine/ xylazine vs. nembutal anesthesia, with the dominance of hippocampal complexity. In nembutal anesthesia the complexity dominance moved to pontine level, and ponto- hippocampocortical decreasing complexity gradient was established. This study has proved the Higuchi fractal dimension as a valuable tool for measuring the anesthesia induced inter- structure EEG complexity.",
publisher = "World Scientific Publ Co Pte Ltd, Singapore",
journal = "Fractals-Complex Geometry Patterns and Scaling in Nature and Society",
title = "Different anesthesia in rat induces distinct inter-structure brain dynamic detected by higuchi fractal dimension",
pages = "123-113",
number = "1",
volume = "19",
doi = "10.1142/S0218348X1100521X"
}

Spasić, S., Kesic, S., Kalauzi, A.,& Šaponjić, J.. (2011). Different anesthesia in rat induces distinct inter-structure brain dynamic detected by higuchi fractal dimension. in Fractals-Complex Geometry Patterns and Scaling in Nature and Society
World Scientific Publ Co Pte Ltd, Singapore., 19(1), 113-123.
https://doi.org/10.1142/S0218348X1100521X

Spasić S, Kesic S, Kalauzi A, Šaponjić J. Different anesthesia in rat induces distinct inter-structure brain dynamic detected by higuchi fractal dimension. in Fractals-Complex Geometry Patterns and Scaling in Nature and Society. 2011;19(1):113-123.
doi:10.1142/S0218348X1100521X .

Spasić, Slađana, Kesic, Srdjan, Kalauzi, Aleksandar, Šaponjić, Jasna, "Different anesthesia in rat induces distinct inter-structure brain dynamic detected by higuchi fractal dimension" in Fractals-Complex Geometry Patterns and Scaling in Nature and Society, 19, no. 1 (2011):113-123,
https://doi.org/10.1142/S0218348X1100521X . .