TY  - CONF
AU  - Opačić, Miloš
AU  - Stevic, Zorica
AU  - Živić, Miroslav
AU  - Spasojević, Ivan
PY  - 2016
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/2957
AB  - Background: ALS is an oxidative stress-related fastpaced
motor neuron disease for which there are no
accurate biomarkers of progression. This largely hampers
the development of therapeutics. Our aim was to test the
applicability of oxidation-reduction potential (ORP) of
cerebrospinal fluid (CSF) in ALS progression follow-up.
Methods: ORP was measured using RedoxSYS (Aytu
BioScience, Inc.) in CSF of 49 ALS patients (mean age
63 1.29 years; range 43-80 years; mean ALSFRSr score
37.47 0.90, range 21-48; m/f = 35/14) and 15 controls
(mean age 48.93 3.68 years, range 21-67 years; m/f =
10/5).
Results: Pearson correlation coefficient (R) between
ALSFRSr score and ORP was 0.27 (p = 0.06). R was
higher ( 0.45) when two outlier values were excluded
from the calculus. Importantly, ALS patients had significantly
higher mean ORP (ALS: 121.83 2.76mV;
controls: 111.14 2.94 mV; p = 0.033). The difference
was also significant for ORP normalized to age. Of note,
ORP is reciprocally proportional to the pro-oxidative
settings in biological samples.
Discussion: Increased ORP values in ALS patients
further confirm the role of oxidative stress in this
neurodegenerative disease. ORP might find application
as a biomarker for ALS progression/prognosis but further
measurements on a larger cohort is warranted.
PB  - Taylor and Francis
C3  - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
T1  - Oxidation-reduction potential of cerebrospinal fluid as a potential biomarker for ALS progression
SP  - 183
DO  - 10.1080/21678421.2016.1232061
ER  - 

@conference{
author = "Opačić, Miloš and Stevic, Zorica and Živić, Miroslav and Spasojević, Ivan",
year = "2016",
abstract = "Background: ALS is an oxidative stress-related fastpaced
motor neuron disease for which there are no
accurate biomarkers of progression. This largely hampers
the development of therapeutics. Our aim was to test the
applicability of oxidation-reduction potential (ORP) of
cerebrospinal fluid (CSF) in ALS progression follow-up.
Methods: ORP was measured using RedoxSYS (Aytu
BioScience, Inc.) in CSF of 49 ALS patients (mean age
63 1.29 years; range 43-80 years; mean ALSFRSr score
37.47 0.90, range 21-48; m/f = 35/14) and 15 controls
(mean age 48.93 3.68 years, range 21-67 years; m/f =
10/5).
Results: Pearson correlation coefficient (R) between
ALSFRSr score and ORP was 0.27 (p = 0.06). R was
higher ( 0.45) when two outlier values were excluded
from the calculus. Importantly, ALS patients had significantly
higher mean ORP (ALS: 121.83 2.76mV;
controls: 111.14 2.94 mV; p = 0.033). The difference
was also significant for ORP normalized to age. Of note,
ORP is reciprocally proportional to the pro-oxidative
settings in biological samples.
Discussion: Increased ORP values in ALS patients
further confirm the role of oxidative stress in this
neurodegenerative disease. ORP might find application
as a biomarker for ALS progression/prognosis but further
measurements on a larger cohort is warranted.",
publisher = "Taylor and Francis",
journal = "Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration",
title = "Oxidation-reduction potential of cerebrospinal fluid as a potential biomarker for ALS progression",
pages = "183",
doi = "10.1080/21678421.2016.1232061"
}

Opačić, M., Stevic, Z., Živić, M.,& Spasojević, I.. (2016). Oxidation-reduction potential of cerebrospinal fluid as a potential biomarker for ALS progression. in Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Taylor and Francis., 183.
https://doi.org/10.1080/21678421.2016.1232061

Opačić M, Stevic Z, Živić M, Spasojević I. Oxidation-reduction potential of cerebrospinal fluid as a potential biomarker for ALS progression. in Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 2016;:183.
doi:10.1080/21678421.2016.1232061 .

Opačić, Miloš, Stevic, Zorica, Živić, Miroslav, Spasojević, Ivan, "Oxidation-reduction potential of cerebrospinal fluid as a potential biomarker for ALS progression" in Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration (2016):183,
https://doi.org/10.1080/21678421.2016.1232061 . .