TY  - JOUR
AU  - Grbić, Gordana
AU  - Ćulić, Milka
AU  - Martać, Ljiljana
AU  - Kesić, Srđan Ž.
AU  - Soković, Marina
AU  - Spasić, Slađana
AU  - Đoković, Dejan
PY  - 2006
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/2945
AB  - We have decided to detect the seizure brain activity induced by camphor essential oil in rats, as there are still reports of severe intoxication in humans by camphor. The experiments were performed on adult Wistar male rats. The surgery and the acute electrophysiological recordings were done under pentobarbital sodium anesthesia. Local field potentials of cerebral parietal cortex were recorded. The rats were injected by camphor essential oil (150-675 μl/kg b.w., in 1 ml of saline, i.p). We analyzed by Fast Fourier Transform the digitized electrocortical signals before and up 2-3 h after essential oil administration at the sampling rate of 256 Hz. There was a great increase of the mean total power spectra, a relative increase of the power in delta range and decreases of theta and beta ranges when seizural activity with spikes and waves of large amplitude occurred at the level of cerebral cortex 5-30 min after administration of camphor oil at doses >300 μl/kg b.w. It is necessary to investigate further the dose dependent effectiveness of each terpenoid constituent of camphor essential oil on brain activity in order to elucidate the relative safety of the usage of essential oils with these terpenoids.
PB  - Serbian Union of Biological Sciences
T2  - Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica
T1  - Trovanje kamforom - spektralna analiza aktivnosti mozga pacova
T1  - Camphor oil poisoning: Spectral analysis of rat brain activity
EP  - 238
IS  - 3
SP  - 233
VL  - 42
UR  - https://hdl.handle.net/21.15107/rcub_rimsi_2945
ER  - 

@article{
author = "Grbić, Gordana and Ćulić, Milka and Martać, Ljiljana and Kesić, Srđan Ž. and Soković, Marina and Spasić, Slađana and Đoković, Dejan",
year = "2006",
abstract = "We have decided to detect the seizure brain activity induced by camphor essential oil in rats, as there are still reports of severe intoxication in humans by camphor. The experiments were performed on adult Wistar male rats. The surgery and the acute electrophysiological recordings were done under pentobarbital sodium anesthesia. Local field potentials of cerebral parietal cortex were recorded. The rats were injected by camphor essential oil (150-675 μl/kg b.w., in 1 ml of saline, i.p). We analyzed by Fast Fourier Transform the digitized electrocortical signals before and up 2-3 h after essential oil administration at the sampling rate of 256 Hz. There was a great increase of the mean total power spectra, a relative increase of the power in delta range and decreases of theta and beta ranges when seizural activity with spikes and waves of large amplitude occurred at the level of cerebral cortex 5-30 min after administration of camphor oil at doses >300 μl/kg b.w. It is necessary to investigate further the dose dependent effectiveness of each terpenoid constituent of camphor essential oil on brain activity in order to elucidate the relative safety of the usage of essential oils with these terpenoids.",
publisher = "Serbian Union of Biological Sciences",
journal = "Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica",
title = "Trovanje kamforom - spektralna analiza aktivnosti mozga pacova, Camphor oil poisoning: Spectral analysis of rat brain activity",
pages = "238-233",
number = "3",
volume = "42",
url = "https://hdl.handle.net/21.15107/rcub_rimsi_2945"
}

Grbić, G., Ćulić, M., Martać, L., Kesić, S. Ž., Soković, M., Spasić, S.,& Đoković, D.. (2006). Trovanje kamforom - spektralna analiza aktivnosti mozga pacova. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica
Serbian Union of Biological Sciences., 42(3), 233-238.
https://hdl.handle.net/21.15107/rcub_rimsi_2945

Grbić G, Ćulić M, Martać L, Kesić SŽ, Soković M, Spasić S, Đoković D. Trovanje kamforom - spektralna analiza aktivnosti mozga pacova. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica. 2006;42(3):233-238.
https://hdl.handle.net/21.15107/rcub_rimsi_2945 .

Grbić, Gordana, Ćulić, Milka, Martać, Ljiljana, Kesić, Srđan Ž., Soković, Marina, Spasić, Slađana, Đoković, Dejan, "Trovanje kamforom - spektralna analiza aktivnosti mozga pacova" in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42, no. 3 (2006):233-238,
https://hdl.handle.net/21.15107/rcub_rimsi_2945 .

TY  - JOUR
AU  - Martać, Ljiljana
AU  - Kesić, Srđan Ž.
AU  - Ćulić, Milka
AU  - Grbić, Gordana
AU  - Spasić, Slađana
AU  - Sekulić, Slobodan
AU  - Lalošević, Dušan
PY  - 2006
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/2877
AB  - The aim of our study was to investigate the electrophysiological effects of aluminium neurotoxicity. This animal model of neurodegenerative dementia was induced by chronic treatment of Wistarrats with aluminum chloride for 4 weeks - 2mg Al/kg, i.p, per day. Electrophysiological recordings of left and right somatosensory cortical areas of animals treated by aluminium and the control rats were done under Nembutal anesthesia. Analog to the digital one conversion of the recorded signals was performed at the sampling rate of 256 Hz. Spectral analysis of electrocortical activity during sequences of 120 s (divided in epochs of 8s) was obtained by Fast Fourier Transformation while fractal dimension (FD) of these signals was calculated by Higuchi's algorithm. The relative power spectra of cerebral activity were increased in delta frequency range and decreased in (8.1-32.0 Hz) range in aluminium treated animals compared to the controls. The average fractal dimension of electrocortical activity in aluminium treated animals was lower - 1.290 than the average fractal dimension of electrocortical activity in the control rats - 1.377. Spectral and fractal characteristics of brain activity could bean electrophysiological sign of developing neurodegenerative process similar to the Alzheimer's dementia.
T2  - Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica
T1  - Efekat neurotoksičnosti aluminijuma na elektrokortikalnu aktivnost mozga pacova
T1  - Effect of aluminium neurotoxicity on the rat brain electrocortical activity
EP  - 225
IS  - 3
SP  - 219
VL  - 42
UR  - https://hdl.handle.net/21.15107/rcub_rimsi_2877
ER  - 

@article{
author = "Martać, Ljiljana and Kesić, Srđan Ž. and Ćulić, Milka and Grbić, Gordana and Spasić, Slađana and Sekulić, Slobodan and Lalošević, Dušan",
year = "2006",
abstract = "The aim of our study was to investigate the electrophysiological effects of aluminium neurotoxicity. This animal model of neurodegenerative dementia was induced by chronic treatment of Wistarrats with aluminum chloride for 4 weeks - 2mg Al/kg, i.p, per day. Electrophysiological recordings of left and right somatosensory cortical areas of animals treated by aluminium and the control rats were done under Nembutal anesthesia. Analog to the digital one conversion of the recorded signals was performed at the sampling rate of 256 Hz. Spectral analysis of electrocortical activity during sequences of 120 s (divided in epochs of 8s) was obtained by Fast Fourier Transformation while fractal dimension (FD) of these signals was calculated by Higuchi's algorithm. The relative power spectra of cerebral activity were increased in delta frequency range and decreased in (8.1-32.0 Hz) range in aluminium treated animals compared to the controls. The average fractal dimension of electrocortical activity in aluminium treated animals was lower - 1.290 than the average fractal dimension of electrocortical activity in the control rats - 1.377. Spectral and fractal characteristics of brain activity could bean electrophysiological sign of developing neurodegenerative process similar to the Alzheimer's dementia.",
journal = "Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica",
title = "Efekat neurotoksičnosti aluminijuma na elektrokortikalnu aktivnost mozga pacova, Effect of aluminium neurotoxicity on the rat brain electrocortical activity",
pages = "225-219",
number = "3",
volume = "42",
url = "https://hdl.handle.net/21.15107/rcub_rimsi_2877"
}

Martać, L., Kesić, S. Ž., Ćulić, M., Grbić, G., Spasić, S., Sekulić, S.,& Lalošević, D.. (2006). Efekat neurotoksičnosti aluminijuma na elektrokortikalnu aktivnost mozga pacova. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42(3), 219-225.
https://hdl.handle.net/21.15107/rcub_rimsi_2877

Martać L, Kesić SŽ, Ćulić M, Grbić G, Spasić S, Sekulić S, Lalošević D. Efekat neurotoksičnosti aluminijuma na elektrokortikalnu aktivnost mozga pacova. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica. 2006;42(3):219-225.
https://hdl.handle.net/21.15107/rcub_rimsi_2877 .

Martać, Ljiljana, Kesić, Srđan Ž., Ćulić, Milka, Grbić, Gordana, Spasić, Slađana, Sekulić, Slobodan, Lalošević, Dušan, "Efekat neurotoksičnosti aluminijuma na elektrokortikalnu aktivnost mozga pacova" in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42, no. 3 (2006):219-225,
https://hdl.handle.net/21.15107/rcub_rimsi_2877 .