TY  - JOUR
AU  - Ristić, Milenko
AU  - Dekić, Biljana
AU  - Dekić, Vidoslav
AU  - Stanojević, Miloš
AU  - Milošević, Slaviša
AU  - Aksić, Marija
AU  - Janićević, Suzana
PY  - 2023
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/3203
AB  - Plants from the genus Achillea are rich in biologically active ingredients and are traditionally known for their healing potential.
In this research, the phytochemical profile was investigated, the content of total phenolics and flavonoids was determined and
examined the acute toxicity, antioxidant and antidiabetic activity of ethanolic, ethyl acetate and chloroform extracts of Achillea
abrotanoides (Vis.) Vis., Achillea chrysocoma Friv., Achillea grandifolia Friv. and Achillea millefolium L. Tested extracts
showed the presence of different groups of phytochemicals, while the high content of total phenolics and flavonoids was
quantified, especially in the ethanolic and ethyl acetate extracts. The acute toxicity was examined in the Artemia salina model,
where the extracts did not show significant toxicity after an incubation period of 24 hours, while after 48 hours, strong acute
toxicity was recorded in chloroform extracts of A. millefolium and A. chrysocoma. Extracts were tested for antioxidant activity
using the DPPH test, as well as antidiabetic activity based on their ability to inhibit the α-amylase. Ethanol and ethyl acetate
extracts of A. abrotanoides and A. millefolium showed a great ability to reduce DPPH radicals, while the same extracts
accomplished a significant inhibitory potential on α-amylase. Also, a correlation was established between the content of total
phenolics and flavonoids with the antioxidant activity of the extracts.
PB  - Romanian society for pharmaceutical sciences
T2  - FARMACIA
T1  - PHYTOCHEMICAL INVESTIGATION, ACUTE TOXICITY, ANTIOXIDANT AND ANTIDIABETIC ACTIVITY OF EXTRACTS FROM AERIAL PARTS OF FOUR WILD GROWING ACHILLEA SPECIES
VL  - 71,4
DO  - 10.31925/farmacia.2023.4.15
ER  - 

@article{
author = "Ristić, Milenko and Dekić, Biljana and Dekić, Vidoslav and Stanojević, Miloš and Milošević, Slaviša and Aksić, Marija and Janićević, Suzana",
year = "2023",
abstract = "Plants from the genus Achillea are rich in biologically active ingredients and are traditionally known for their healing potential.
In this research, the phytochemical profile was investigated, the content of total phenolics and flavonoids was determined and
examined the acute toxicity, antioxidant and antidiabetic activity of ethanolic, ethyl acetate and chloroform extracts of Achillea
abrotanoides (Vis.) Vis., Achillea chrysocoma Friv., Achillea grandifolia Friv. and Achillea millefolium L. Tested extracts
showed the presence of different groups of phytochemicals, while the high content of total phenolics and flavonoids was
quantified, especially in the ethanolic and ethyl acetate extracts. The acute toxicity was examined in the Artemia salina model,
where the extracts did not show significant toxicity after an incubation period of 24 hours, while after 48 hours, strong acute
toxicity was recorded in chloroform extracts of A. millefolium and A. chrysocoma. Extracts were tested for antioxidant activity
using the DPPH test, as well as antidiabetic activity based on their ability to inhibit the α-amylase. Ethanol and ethyl acetate
extracts of A. abrotanoides and A. millefolium showed a great ability to reduce DPPH radicals, while the same extracts
accomplished a significant inhibitory potential on α-amylase. Also, a correlation was established between the content of total
phenolics and flavonoids with the antioxidant activity of the extracts.",
publisher = "Romanian society for pharmaceutical sciences",
journal = "FARMACIA",
title = "PHYTOCHEMICAL INVESTIGATION, ACUTE TOXICITY, ANTIOXIDANT AND ANTIDIABETIC ACTIVITY OF EXTRACTS FROM AERIAL PARTS OF FOUR WILD GROWING ACHILLEA SPECIES",
volume = "71,4",
doi = "10.31925/farmacia.2023.4.15"
}

Ristić, M., Dekić, B., Dekić, V., Stanojević, M., Milošević, S., Aksić, M.,& Janićević, S.. (2023). PHYTOCHEMICAL INVESTIGATION, ACUTE TOXICITY, ANTIOXIDANT AND ANTIDIABETIC ACTIVITY OF EXTRACTS FROM AERIAL PARTS OF FOUR WILD GROWING ACHILLEA SPECIES. in FARMACIA
Romanian society for pharmaceutical sciences., 71,4.
https://doi.org/10.31925/farmacia.2023.4.15

Ristić M, Dekić B, Dekić V, Stanojević M, Milošević S, Aksić M, Janićević S. PHYTOCHEMICAL INVESTIGATION, ACUTE TOXICITY, ANTIOXIDANT AND ANTIDIABETIC ACTIVITY OF EXTRACTS FROM AERIAL PARTS OF FOUR WILD GROWING ACHILLEA SPECIES. in FARMACIA. 2023;71,4.
doi:10.31925/farmacia.2023.4.15 .

Ristić, Milenko, Dekić, Biljana, Dekić, Vidoslav, Stanojević, Miloš, Milošević, Slaviša, Aksić, Marija, Janićević, Suzana, "PHYTOCHEMICAL INVESTIGATION, ACUTE TOXICITY, ANTIOXIDANT AND ANTIDIABETIC ACTIVITY OF EXTRACTS FROM AERIAL PARTS OF FOUR WILD GROWING ACHILLEA SPECIES" in FARMACIA, 71,4 (2023),
https://doi.org/10.31925/farmacia.2023.4.15 . .