TY  - JOUR
AU  - Dučić, Tanja
AU  - Alves, Carla
AU  - Vučinić, Željko
AU  - Lázaro-Martínez, Juan
AU  - Petković, Marijana
AU  - Soto, Juan
AU  - Mutavdžić, Dragosav
AU  - Martinez de Yuso Garcia, Maria del Valle
AU  - Radotić, Ksenija
AU  - Algarra, Manuel
PY  - 2022
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1558
AB  - S and N-doped carbon dots (S-CDs and N-CDs) and their cisplatin (cis-Pt) derivatives.
(S-CDs@cis-Pt and N-CDs@cis-Pt) were tested on two ovarian cancer cell lines: A2780 and A2780 cells
resistant to cis-Pt (A2780R). Several spectroscopic techniques were employed to check S-CDs@cis-Pt and
N-CDs@cis-Pt: solid- and solution-state nuclear magnetic resonance, matrix-assisted laser desorption,
ionization time-of-flight mass spectrometry, and X-ray photoelectron spectroscopy. In addition,
synchrotron-based Fourier Transformed Infrared spectro-microscopy was used to evaluate the biochemical
changes in cells after treatment with cis-Pt, S-CDs, N-CDs, or S-CDs@cis-Pt and N-CDs@cis-Pt, respectively.
Computational chemistry was applied to establish the model for the most stable bond between
S-CDs and N-CDs and cis-Pt. The results revealed the successful modification of S-CDs and N-CDs with
cis-Pt and the formation of a stable composite system that can be used for drug delivery to cancer cells and likewise to overcome acquired cis-Pt resistance. Nanoparticle treatment of A2780 and A2780R cells
led to the changes in their structure of lipids, proteins, and nucleic acids depending on the treatment. The
results showed the S-CDs@cis-Pt and N-CDs@cis-Pt might be used in the combination with cis-Pt to treat
the adenocarcinoma, thus having a potential to be further developed as drug delivery systems.
PB  - Elsevier
T2  - Journal of Colloid and Interface Science
T1  - S, N-doped carbon dots-based cisplatin delivery system in adenocarcinoma cells: Spectroscopical and computational approach
EP  - 237
IS  - 623
SP  - 226
DO  - 10.1016/j.jcis.2022.05.005
ER  - 

@article{
author = "Dučić, Tanja and Alves, Carla and Vučinić, Željko and Lázaro-Martínez, Juan and Petković, Marijana and Soto, Juan and Mutavdžić, Dragosav and Martinez de Yuso Garcia, Maria del Valle and Radotić, Ksenija and Algarra, Manuel",
year = "2022",
abstract = "S and N-doped carbon dots (S-CDs and N-CDs) and their cisplatin (cis-Pt) derivatives.
(S-CDs@cis-Pt and N-CDs@cis-Pt) were tested on two ovarian cancer cell lines: A2780 and A2780 cells
resistant to cis-Pt (A2780R). Several spectroscopic techniques were employed to check S-CDs@cis-Pt and
N-CDs@cis-Pt: solid- and solution-state nuclear magnetic resonance, matrix-assisted laser desorption,
ionization time-of-flight mass spectrometry, and X-ray photoelectron spectroscopy. In addition,
synchrotron-based Fourier Transformed Infrared spectro-microscopy was used to evaluate the biochemical
changes in cells after treatment with cis-Pt, S-CDs, N-CDs, or S-CDs@cis-Pt and N-CDs@cis-Pt, respectively.
Computational chemistry was applied to establish the model for the most stable bond between
S-CDs and N-CDs and cis-Pt. The results revealed the successful modification of S-CDs and N-CDs with
cis-Pt and the formation of a stable composite system that can be used for drug delivery to cancer cells and likewise to overcome acquired cis-Pt resistance. Nanoparticle treatment of A2780 and A2780R cells
led to the changes in their structure of lipids, proteins, and nucleic acids depending on the treatment. The
results showed the S-CDs@cis-Pt and N-CDs@cis-Pt might be used in the combination with cis-Pt to treat
the adenocarcinoma, thus having a potential to be further developed as drug delivery systems.",
publisher = "Elsevier",
journal = "Journal of Colloid and Interface Science",
title = "S, N-doped carbon dots-based cisplatin delivery system in adenocarcinoma cells: Spectroscopical and computational approach",
pages = "237-226",
number = "623",
doi = "10.1016/j.jcis.2022.05.005"
}

Dučić, T., Alves, C., Vučinić, Ž., Lázaro-Martínez, J., Petković, M., Soto, J., Mutavdžić, D., Martinez de Yuso Garcia, M. d. V., Radotić, K.,& Algarra, M.. (2022). S, N-doped carbon dots-based cisplatin delivery system in adenocarcinoma cells: Spectroscopical and computational approach. in Journal of Colloid and Interface Science
Elsevier.(623), 226-237.
https://doi.org/10.1016/j.jcis.2022.05.005

Dučić T, Alves C, Vučinić Ž, Lázaro-Martínez J, Petković M, Soto J, Mutavdžić D, Martinez de Yuso Garcia MDV, Radotić K, Algarra M. S, N-doped carbon dots-based cisplatin delivery system in adenocarcinoma cells: Spectroscopical and computational approach. in Journal of Colloid and Interface Science. 2022;(623):226-237.
doi:10.1016/j.jcis.2022.05.005 .

Dučić, Tanja, Alves, Carla, Vučinić, Željko, Lázaro-Martínez, Juan, Petković, Marijana, Soto, Juan, Mutavdžić, Dragosav, Martinez de Yuso Garcia, Maria del Valle, Radotić, Ksenija, Algarra, Manuel, "S, N-doped carbon dots-based cisplatin delivery system in adenocarcinoma cells: Spectroscopical and computational approach" in Journal of Colloid and Interface Science, no. 623 (2022):226-237,
https://doi.org/10.1016/j.jcis.2022.05.005 . .