TY  - JOUR
AU  - Dučić, Tanja
AU  - Alves, Carla
AU  - Vučinić, Željko
AU  - Lázaro-Martínez, Juan
AU  - Petković, Marijana
AU  - Soto, Juan
AU  - Mutavdžić, Dragosav
AU  - Martinez de Yuso Garcia, Maria del Valle
AU  - Radotić, Ksenija
AU  - Algarra, Manuel
PY  - 2022
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1558
AB  - S and N-doped carbon dots (S-CDs and N-CDs) and their cisplatin (cis-Pt) derivatives.
(S-CDs@cis-Pt and N-CDs@cis-Pt) were tested on two ovarian cancer cell lines: A2780 and A2780 cells
resistant to cis-Pt (A2780R). Several spectroscopic techniques were employed to check S-CDs@cis-Pt and
N-CDs@cis-Pt: solid- and solution-state nuclear magnetic resonance, matrix-assisted laser desorption,
ionization time-of-flight mass spectrometry, and X-ray photoelectron spectroscopy. In addition,
synchrotron-based Fourier Transformed Infrared spectro-microscopy was used to evaluate the biochemical
changes in cells after treatment with cis-Pt, S-CDs, N-CDs, or S-CDs@cis-Pt and N-CDs@cis-Pt, respectively.
Computational chemistry was applied to establish the model for the most stable bond between
S-CDs and N-CDs and cis-Pt. The results revealed the successful modification of S-CDs and N-CDs with
cis-Pt and the formation of a stable composite system that can be used for drug delivery to cancer cells and likewise to overcome acquired cis-Pt resistance. Nanoparticle treatment of A2780 and A2780R cells
led to the changes in their structure of lipids, proteins, and nucleic acids depending on the treatment. The
results showed the S-CDs@cis-Pt and N-CDs@cis-Pt might be used in the combination with cis-Pt to treat
the adenocarcinoma, thus having a potential to be further developed as drug delivery systems.
PB  - Elsevier
T2  - Journal of Colloid and Interface Science
T1  - S, N-doped carbon dots-based cisplatin delivery system in adenocarcinoma cells: Spectroscopical and computational approach
EP  - 237
IS  - 623
SP  - 226
DO  - 10.1016/j.jcis.2022.05.005
ER  - 

@article{
author = "Dučić, Tanja and Alves, Carla and Vučinić, Željko and Lázaro-Martínez, Juan and Petković, Marijana and Soto, Juan and Mutavdžić, Dragosav and Martinez de Yuso Garcia, Maria del Valle and Radotić, Ksenija and Algarra, Manuel",
year = "2022",
abstract = "S and N-doped carbon dots (S-CDs and N-CDs) and their cisplatin (cis-Pt) derivatives.
(S-CDs@cis-Pt and N-CDs@cis-Pt) were tested on two ovarian cancer cell lines: A2780 and A2780 cells
resistant to cis-Pt (A2780R). Several spectroscopic techniques were employed to check S-CDs@cis-Pt and
N-CDs@cis-Pt: solid- and solution-state nuclear magnetic resonance, matrix-assisted laser desorption,
ionization time-of-flight mass spectrometry, and X-ray photoelectron spectroscopy. In addition,
synchrotron-based Fourier Transformed Infrared spectro-microscopy was used to evaluate the biochemical
changes in cells after treatment with cis-Pt, S-CDs, N-CDs, or S-CDs@cis-Pt and N-CDs@cis-Pt, respectively.
Computational chemistry was applied to establish the model for the most stable bond between
S-CDs and N-CDs and cis-Pt. The results revealed the successful modification of S-CDs and N-CDs with
cis-Pt and the formation of a stable composite system that can be used for drug delivery to cancer cells and likewise to overcome acquired cis-Pt resistance. Nanoparticle treatment of A2780 and A2780R cells
led to the changes in their structure of lipids, proteins, and nucleic acids depending on the treatment. The
results showed the S-CDs@cis-Pt and N-CDs@cis-Pt might be used in the combination with cis-Pt to treat
the adenocarcinoma, thus having a potential to be further developed as drug delivery systems.",
publisher = "Elsevier",
journal = "Journal of Colloid and Interface Science",
title = "S, N-doped carbon dots-based cisplatin delivery system in adenocarcinoma cells: Spectroscopical and computational approach",
pages = "237-226",
number = "623",
doi = "10.1016/j.jcis.2022.05.005"
}

Dučić, T., Alves, C., Vučinić, Ž., Lázaro-Martínez, J., Petković, M., Soto, J., Mutavdžić, D., Martinez de Yuso Garcia, M. d. V., Radotić, K.,& Algarra, M.. (2022). S, N-doped carbon dots-based cisplatin delivery system in adenocarcinoma cells: Spectroscopical and computational approach. in Journal of Colloid and Interface Science
Elsevier.(623), 226-237.
https://doi.org/10.1016/j.jcis.2022.05.005

Dučić T, Alves C, Vučinić Ž, Lázaro-Martínez J, Petković M, Soto J, Mutavdžić D, Martinez de Yuso Garcia MDV, Radotić K, Algarra M. S, N-doped carbon dots-based cisplatin delivery system in adenocarcinoma cells: Spectroscopical and computational approach. in Journal of Colloid and Interface Science. 2022;(623):226-237.
doi:10.1016/j.jcis.2022.05.005 .

Dučić, Tanja, Alves, Carla, Vučinić, Željko, Lázaro-Martínez, Juan, Petković, Marijana, Soto, Juan, Mutavdžić, Dragosav, Martinez de Yuso Garcia, Maria del Valle, Radotić, Ksenija, Algarra, Manuel, "S, N-doped carbon dots-based cisplatin delivery system in adenocarcinoma cells: Spectroscopical and computational approach" in Journal of Colloid and Interface Science, no. 623 (2022):226-237,
https://doi.org/10.1016/j.jcis.2022.05.005 . .

TY  - JOUR
AU  - Fischer, Thomas
AU  - Marchetti-Deschmann, Martina
AU  - Assis, Ana Cristina
AU  - Levin Elad, Michal
AU  - Algarra, Manuel
AU  - Barac, Marko
AU  - Bogdanović Radović, Iva
AU  - Cicconi, Flavio
AU  - Claes, Britt
AU  - Frascione, Nunzianda
AU  - George, Sony
AU  - Guedes, Alexandra
AU  - Heaton, Cameron
AU  - Heeren, Ron
AU  - Lazić, Violeta
AU  - Lerma, José Luis
AU  - Martinez de Yuso Garcia, Maria del Valle
AU  - Nosko, Martin
AU  - O’Hara, John
AU  - Oshina, Ilze
AU  - Palucci, Antonio
AU  - Pawlaczyk, Aleksandra
AU  - Zelená Pospíšková, Kristýna
AU  - de Puit, Marcel
AU  - Radotić, Ksenija
AU  - Rēpele, Māra
AU  - Ristova, Mimoza
AU  - Romolo, Francesco Saverio
AU  - Šafařík, Ivo
AU  - Siketić, Zdravko
AU  - Spigulis, Janis
AU  - Szynkowska-Jozwik, Malgorzata Iwona
AU  - Tsiatsiuyeu, Andrei
AU  - Vella, Joanna
AU  - Dawson, Lorna
AU  - Rödiger, Stefan
AU  - Francese, Simona
PY  - 2022
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1562
AB  - The forensic scenario, on which the round robin study was based, simulated a suspected intentional manipulation
of a real estate rental agreement consisting of a total of three pages. The aims of this study were to (i) establish
the amount and reliability of information extractable from a single type of evidence and to (ii) provide suggestions
on the most suitable combination of compatible techniques for a multi-modal imaging approach to
forgery detection. To address these aims, seventeen laboratories from sixteen countries were invited to answer
the following tasks questions: (i) which printing technique was used? (ii) were the three pages printed with the
same printer? (iii) were the three pages made from the same paper? (iv) were the three pages originally stapled?
(v) were the headings and signatures written with the same ink? and (vi) were headings and signatures of the
same age on all pages? The methods used were classified into the following categories: Optical spectroscopy,
including multispectral imaging, smartphone mapping, UV-luminescence and LIBS; Infrared spectroscopy,
including Raman and FTIR (micro-)spectroscopy; X-ray spectroscopy, including SEM-EDX, PIXE and XPS; Mass
spectrometry, including ICPMS, SIMS, MALDI and LDIMS; Electrostatic imaging, as well as non-imaging
methods, such as non-multimodal visual inspection, (micro-)spectroscopy, physical testing and thin layer
chromatography. The performance of the techniques was evaluated as the proportion of discriminated sample
pairs to all possible sample pairs. For the undiscriminated sample pairs, a distinction was made between undecidability
and false positive claims. It was found that none of the methods used were able to solve all tasks
completely and/or correctly and that certain methods were a priori judged unsuitable by the laboratories for
some tasks. Correct results were generally achieved for the discrimination of printer toners, whereas incorrect
results in the discrimination of inks. For the discrimination of paper, solid state analytical methods proved to be
superior to mass spectrometric methods. None of the participating laboratories deemed addressing ink age
feasible. It was concluded that correct forensic statements can only be achieved by the complementary application
of different methods and that the classical approach of round robin studies to send standardised subsamples
to the participants is not feasible for a true multimodal approach if the techniques are not available at
one location.
PB  - Elsevier
T2  - Science & Justice
T1  - Profiling and imaging of forensic evidence – A pan-European forensic round robin study part 1: Document forgery
EP  - 447
IS  - 4
SP  - 433
VL  - 62
DO  - 10.1016/j.scijus.2022.06.001
ER  - 

@article{
author = "Fischer, Thomas and Marchetti-Deschmann, Martina and Assis, Ana Cristina and Levin Elad, Michal and Algarra, Manuel and Barac, Marko and Bogdanović Radović, Iva and Cicconi, Flavio and Claes, Britt and Frascione, Nunzianda and George, Sony and Guedes, Alexandra and Heaton, Cameron and Heeren, Ron and Lazić, Violeta and Lerma, José Luis and Martinez de Yuso Garcia, Maria del Valle and Nosko, Martin and O’Hara, John and Oshina, Ilze and Palucci, Antonio and Pawlaczyk, Aleksandra and Zelená Pospíšková, Kristýna and de Puit, Marcel and Radotić, Ksenija and Rēpele, Māra and Ristova, Mimoza and Romolo, Francesco Saverio and Šafařík, Ivo and Siketić, Zdravko and Spigulis, Janis and Szynkowska-Jozwik, Malgorzata Iwona and Tsiatsiuyeu, Andrei and Vella, Joanna and Dawson, Lorna and Rödiger, Stefan and Francese, Simona",
year = "2022",
abstract = "The forensic scenario, on which the round robin study was based, simulated a suspected intentional manipulation
of a real estate rental agreement consisting of a total of three pages. The aims of this study were to (i) establish
the amount and reliability of information extractable from a single type of evidence and to (ii) provide suggestions
on the most suitable combination of compatible techniques for a multi-modal imaging approach to
forgery detection. To address these aims, seventeen laboratories from sixteen countries were invited to answer
the following tasks questions: (i) which printing technique was used? (ii) were the three pages printed with the
same printer? (iii) were the three pages made from the same paper? (iv) were the three pages originally stapled?
(v) were the headings and signatures written with the same ink? and (vi) were headings and signatures of the
same age on all pages? The methods used were classified into the following categories: Optical spectroscopy,
including multispectral imaging, smartphone mapping, UV-luminescence and LIBS; Infrared spectroscopy,
including Raman and FTIR (micro-)spectroscopy; X-ray spectroscopy, including SEM-EDX, PIXE and XPS; Mass
spectrometry, including ICPMS, SIMS, MALDI and LDIMS; Electrostatic imaging, as well as non-imaging
methods, such as non-multimodal visual inspection, (micro-)spectroscopy, physical testing and thin layer
chromatography. The performance of the techniques was evaluated as the proportion of discriminated sample
pairs to all possible sample pairs. For the undiscriminated sample pairs, a distinction was made between undecidability
and false positive claims. It was found that none of the methods used were able to solve all tasks
completely and/or correctly and that certain methods were a priori judged unsuitable by the laboratories for
some tasks. Correct results were generally achieved for the discrimination of printer toners, whereas incorrect
results in the discrimination of inks. For the discrimination of paper, solid state analytical methods proved to be
superior to mass spectrometric methods. None of the participating laboratories deemed addressing ink age
feasible. It was concluded that correct forensic statements can only be achieved by the complementary application
of different methods and that the classical approach of round robin studies to send standardised subsamples
to the participants is not feasible for a true multimodal approach if the techniques are not available at
one location.",
publisher = "Elsevier",
journal = "Science & Justice",
title = "Profiling and imaging of forensic evidence – A pan-European forensic round robin study part 1: Document forgery",
pages = "447-433",
number = "4",
volume = "62",
doi = "10.1016/j.scijus.2022.06.001"
}

Fischer, T., Marchetti-Deschmann, M., Assis, A. C., Levin Elad, M., Algarra, M., Barac, M., Bogdanović Radović, I., Cicconi, F., Claes, B., Frascione, N., George, S., Guedes, A., Heaton, C., Heeren, R., Lazić, V., Lerma, J. L., Martinez de Yuso Garcia, M. d. V., Nosko, M., O’Hara, J., Oshina, I., Palucci, A., Pawlaczyk, A., Zelená Pospíšková, K., de Puit, M., Radotić, K., Rēpele, M., Ristova, M., Romolo, F. S., Šafařík, I., Siketić, Z., Spigulis, J., Szynkowska-Jozwik, M. I., Tsiatsiuyeu, A., Vella, J., Dawson, L., Rödiger, S.,& Francese, S.. (2022). Profiling and imaging of forensic evidence – A pan-European forensic round robin study part 1: Document forgery. in Science & Justice
Elsevier., 62(4), 433-447.
https://doi.org/10.1016/j.scijus.2022.06.001

Fischer T, Marchetti-Deschmann M, Assis AC, Levin Elad M, Algarra M, Barac M, Bogdanović Radović I, Cicconi F, Claes B, Frascione N, George S, Guedes A, Heaton C, Heeren R, Lazić V, Lerma JL, Martinez de Yuso Garcia MDV, Nosko M, O’Hara J, Oshina I, Palucci A, Pawlaczyk A, Zelená Pospíšková K, de Puit M, Radotić K, Rēpele M, Ristova M, Romolo FS, Šafařík I, Siketić Z, Spigulis J, Szynkowska-Jozwik MI, Tsiatsiuyeu A, Vella J, Dawson L, Rödiger S, Francese S. Profiling and imaging of forensic evidence – A pan-European forensic round robin study part 1: Document forgery. in Science & Justice. 2022;62(4):433-447.
doi:10.1016/j.scijus.2022.06.001 .

Fischer, Thomas, Marchetti-Deschmann, Martina, Assis, Ana Cristina, Levin Elad, Michal, Algarra, Manuel, Barac, Marko, Bogdanović Radović, Iva, Cicconi, Flavio, Claes, Britt, Frascione, Nunzianda, George, Sony, Guedes, Alexandra, Heaton, Cameron, Heeren, Ron, Lazić, Violeta, Lerma, José Luis, Martinez de Yuso Garcia, Maria del Valle, Nosko, Martin, O’Hara, John, Oshina, Ilze, Palucci, Antonio, Pawlaczyk, Aleksandra, Zelená Pospíšková, Kristýna, de Puit, Marcel, Radotić, Ksenija, Rēpele, Māra, Ristova, Mimoza, Romolo, Francesco Saverio, Šafařík, Ivo, Siketić, Zdravko, Spigulis, Janis, Szynkowska-Jozwik, Malgorzata Iwona, Tsiatsiuyeu, Andrei, Vella, Joanna, Dawson, Lorna, Rödiger, Stefan, Francese, Simona, "Profiling and imaging of forensic evidence – A pan-European forensic round robin study part 1: Document forgery" in Science & Justice, 62, no. 4 (2022):433-447,
https://doi.org/10.1016/j.scijus.2022.06.001 . .