TY  - JOUR
AU  - Filipović, Nenad R.
AU  - Bjelogrlic, Snežana
AU  - Todorović, Tamara R.
AU  - Blagojević, Vladimir A.
AU  - Muller, Christian D.
AU  - Marinković, Aleksandar
AU  - Vujcic, Miroslava
AU  - Janović, Barbara
AU  - Malešević, Aleksandar
AU  - Begović, Nebojša
AU  - Sencanski, Milan
AU  - Minic, Dragica
PY  - 2016
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/972
AB  - A new Ni(II) complex, [Ni(L)(H2O)] (1), with diethyl 3,3'-(2,2'-(1,1'-(pyridine-2,6-diyl) bis(ethan-1-yl-1-ylidene)) bis(hydrazin-1-yl-2-ylidene)) bis(3-oxopropanoate) ligand (H2L) was synthesized as a potential chemotherapeutic agent. Polidentate ligand was coordinated to Ni(II) NNN-tridentately, in dianionic form, while monodentate water coordination completed square-planar geometry around metal. Structure in the solution was determined by NMR spectroscopy and the same coordination mode was observed in the solid state using IR spectroscopy and further verified by DFT calculations and electrochemical studies. Thermal stability of 1 was determined in both air and nitrogen atmosphere. Anticancer activity of 1 was investigated on acute monocytic leukemia (THP-1) and pancreatic adenocarcinoma (AsPC-1) cell lines. On THP-1 cells 1 induced powerful apoptotic response (ED50 = 10 +/- 3 mu M), which was revealed to be only partially caspase-dependent, with activation of caspase-8 as the dominant course. This suggested that experimentally validated covalent binding of 1 to DNA is not the only mechanism responsible for programmed cell death. This was supported with experiments on AsPC-1 cells. Although treatment of those cells with 1 resulted in poor apoptotic response, cell cycle changes showed concentration-dependent shifts indicating a dual mechanism of activity. This study also reviews the results of preliminary biological screening, which demonstrates that 1 displays a unique pattern of anticancer activity with at least two mechanisms involved.
PB  - Royal Soc Chemistry, Cambridge
T2  - RSC Advances
T1  - Ni(II) complex with bishydrazone ligand: synthesis, characterization, DNA binding studies and pro-apoptotic and pro-differentiation induction in human cancerous cell lines
EP  - 108740
IS  - 110
SP  - 108726
VL  - 6
DO  - 10.1039/c6ra24604d
ER  - 

@article{
author = "Filipović, Nenad R. and Bjelogrlic, Snežana and Todorović, Tamara R. and Blagojević, Vladimir A. and Muller, Christian D. and Marinković, Aleksandar and Vujcic, Miroslava and Janović, Barbara and Malešević, Aleksandar and Begović, Nebojša and Sencanski, Milan and Minic, Dragica",
year = "2016",
abstract = "A new Ni(II) complex, [Ni(L)(H2O)] (1), with diethyl 3,3'-(2,2'-(1,1'-(pyridine-2,6-diyl) bis(ethan-1-yl-1-ylidene)) bis(hydrazin-1-yl-2-ylidene)) bis(3-oxopropanoate) ligand (H2L) was synthesized as a potential chemotherapeutic agent. Polidentate ligand was coordinated to Ni(II) NNN-tridentately, in dianionic form, while monodentate water coordination completed square-planar geometry around metal. Structure in the solution was determined by NMR spectroscopy and the same coordination mode was observed in the solid state using IR spectroscopy and further verified by DFT calculations and electrochemical studies. Thermal stability of 1 was determined in both air and nitrogen atmosphere. Anticancer activity of 1 was investigated on acute monocytic leukemia (THP-1) and pancreatic adenocarcinoma (AsPC-1) cell lines. On THP-1 cells 1 induced powerful apoptotic response (ED50 = 10 +/- 3 mu M), which was revealed to be only partially caspase-dependent, with activation of caspase-8 as the dominant course. This suggested that experimentally validated covalent binding of 1 to DNA is not the only mechanism responsible for programmed cell death. This was supported with experiments on AsPC-1 cells. Although treatment of those cells with 1 resulted in poor apoptotic response, cell cycle changes showed concentration-dependent shifts indicating a dual mechanism of activity. This study also reviews the results of preliminary biological screening, which demonstrates that 1 displays a unique pattern of anticancer activity with at least two mechanisms involved.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "RSC Advances",
title = "Ni(II) complex with bishydrazone ligand: synthesis, characterization, DNA binding studies and pro-apoptotic and pro-differentiation induction in human cancerous cell lines",
pages = "108740-108726",
number = "110",
volume = "6",
doi = "10.1039/c6ra24604d"
}

Filipović, N. R., Bjelogrlic, S., Todorović, T. R., Blagojević, V. A., Muller, C. D., Marinković, A., Vujcic, M., Janović, B., Malešević, A., Begović, N., Sencanski, M.,& Minic, D.. (2016). Ni(II) complex with bishydrazone ligand: synthesis, characterization, DNA binding studies and pro-apoptotic and pro-differentiation induction in human cancerous cell lines. in RSC Advances
Royal Soc Chemistry, Cambridge., 6(110), 108726-108740.
https://doi.org/10.1039/c6ra24604d

Filipović NR, Bjelogrlic S, Todorović TR, Blagojević VA, Muller CD, Marinković A, Vujcic M, Janović B, Malešević A, Begović N, Sencanski M, Minic D. Ni(II) complex with bishydrazone ligand: synthesis, characterization, DNA binding studies and pro-apoptotic and pro-differentiation induction in human cancerous cell lines. in RSC Advances. 2016;6(110):108726-108740.
doi:10.1039/c6ra24604d .

Filipović, Nenad R., Bjelogrlic, Snežana, Todorović, Tamara R., Blagojević, Vladimir A., Muller, Christian D., Marinković, Aleksandar, Vujcic, Miroslava, Janović, Barbara, Malešević, Aleksandar, Begović, Nebojša, Sencanski, Milan, Minic, Dragica, "Ni(II) complex with bishydrazone ligand: synthesis, characterization, DNA binding studies and pro-apoptotic and pro-differentiation induction in human cancerous cell lines" in RSC Advances, 6, no. 110 (2016):108726-108740,
https://doi.org/10.1039/c6ra24604d . .

TY  - JOUR
AU  - Obradović, Nina
AU  - Mitrić, Miodrag
AU  - Nikolić, Maria Vesna
AU  - Minic, Dragica
AU  - Mitrović, Nebojša S.
AU  - Ristic, Momcilo M.
PY  - 2009
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/366
AB  - Starting mixtures of ZnO, TiO(2) and MgO (0, 1.25 and 2.5 wt.% MgO) powders were mechanically activated for 15 min in a planetary ball mill. The powders obtained were sintered non-isothermally to temperatures between 800 and 1100 degrees C and then held at those temperatures for 120 min. Analysis of the influence of MgO addition on the synthesis of zinc-titanate ceramics showed that its addition increased slightly the temperature at which the reaction process started, accelerated the reaction and resulted in higher sample densities. These results were correlated with the results of structural characterization using X-ray powder diffraction method and SEM analysis. Also, the results of electric resistivity, capacitance and loss tangent of the sintered samples were obtained.
PB  - Elsevier Science Sa, Lausanne
T2  - Journal of Alloys and Compounds
T1  - Influence of MgO addition on the synthesis and electrical properties of sintered zinc-titanate ceramics
EP  - 277
IS  - 1-2
SP  - 272
VL  - 471
DO  - 10.1016/j.jallcom.2008.03.090
ER  - 

@article{
author = "Obradović, Nina and Mitrić, Miodrag and Nikolić, Maria Vesna and Minic, Dragica and Mitrović, Nebojša S. and Ristic, Momcilo M.",
year = "2009",
abstract = "Starting mixtures of ZnO, TiO(2) and MgO (0, 1.25 and 2.5 wt.% MgO) powders were mechanically activated for 15 min in a planetary ball mill. The powders obtained were sintered non-isothermally to temperatures between 800 and 1100 degrees C and then held at those temperatures for 120 min. Analysis of the influence of MgO addition on the synthesis of zinc-titanate ceramics showed that its addition increased slightly the temperature at which the reaction process started, accelerated the reaction and resulted in higher sample densities. These results were correlated with the results of structural characterization using X-ray powder diffraction method and SEM analysis. Also, the results of electric resistivity, capacitance and loss tangent of the sintered samples were obtained.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Journal of Alloys and Compounds",
title = "Influence of MgO addition on the synthesis and electrical properties of sintered zinc-titanate ceramics",
pages = "277-272",
number = "1-2",
volume = "471",
doi = "10.1016/j.jallcom.2008.03.090"
}

Obradović, N., Mitrić, M., Nikolić, M. V., Minic, D., Mitrović, N. S.,& Ristic, M. M.. (2009). Influence of MgO addition on the synthesis and electrical properties of sintered zinc-titanate ceramics. in Journal of Alloys and Compounds
Elsevier Science Sa, Lausanne., 471(1-2), 272-277.
https://doi.org/10.1016/j.jallcom.2008.03.090

Obradović N, Mitrić M, Nikolić MV, Minic D, Mitrović NS, Ristic MM. Influence of MgO addition on the synthesis and electrical properties of sintered zinc-titanate ceramics. in Journal of Alloys and Compounds. 2009;471(1-2):272-277.
doi:10.1016/j.jallcom.2008.03.090 .

Obradović, Nina, Mitrić, Miodrag, Nikolić, Maria Vesna, Minic, Dragica, Mitrović, Nebojša S., Ristic, Momcilo M., "Influence of MgO addition on the synthesis and electrical properties of sintered zinc-titanate ceramics" in Journal of Alloys and Compounds, 471, no. 1-2 (2009):272-277,
https://doi.org/10.1016/j.jallcom.2008.03.090 . .

TY  - JOUR
AU  - Ivetić, Tamara B.
AU  - Vuković, Z.
AU  - Nikolić, Maria Vesna
AU  - Pavlović, Vladimir B
AU  - Nikolic, J. R.
AU  - Minic, Dragica
AU  - Ristic, M. M.
PY  - 2008
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/238
AB  - Powder mixtures of zinc oxide and tin oxide in the molar ratio, ZnO:SnO2 = 2: 1, were mechanically activated in a planetary ball mill in the time intervals of 0-160 min. The adsorption-desorption isotherms, specific surface area, pore volume and pore size distribution spectra of mechanically activated powder mixtures were established by N-2 adsorption at 77 K. Microstructure analysis was performed using scanning electron microscopy (SEM) and digital pattern recognition (DPR) microstructure quantity analysis. The phase composition of the mixed powders was determined by Xray analysis. Mechanochemical activation of the ZnO-SnO2 system resulted in fine grinding of the starting particles and generation of contacts between them, mass transfer at contacts zones and formation of Zn2SnO4 spinel, which was observed after 40 min of activation.
PB  - Elsevier Sci Ltd, Oxford
T2  - Ceramics International
T1  - Morphology investigation of mechanically activated ZnO-SnO2 system
EP  - 643
IS  - 3
SP  - 639
VL  - 34
DO  - 10.1016/j.ceramint.2007.01.003
ER  - 

@article{
author = "Ivetić, Tamara B. and Vuković, Z. and Nikolić, Maria Vesna and Pavlović, Vladimir B and Nikolic, J. R. and Minic, Dragica and Ristic, M. M.",
year = "2008",
abstract = "Powder mixtures of zinc oxide and tin oxide in the molar ratio, ZnO:SnO2 = 2: 1, were mechanically activated in a planetary ball mill in the time intervals of 0-160 min. The adsorption-desorption isotherms, specific surface area, pore volume and pore size distribution spectra of mechanically activated powder mixtures were established by N-2 adsorption at 77 K. Microstructure analysis was performed using scanning electron microscopy (SEM) and digital pattern recognition (DPR) microstructure quantity analysis. The phase composition of the mixed powders was determined by Xray analysis. Mechanochemical activation of the ZnO-SnO2 system resulted in fine grinding of the starting particles and generation of contacts between them, mass transfer at contacts zones and formation of Zn2SnO4 spinel, which was observed after 40 min of activation.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Ceramics International",
title = "Morphology investigation of mechanically activated ZnO-SnO2 system",
pages = "643-639",
number = "3",
volume = "34",
doi = "10.1016/j.ceramint.2007.01.003"
}

Ivetić, T. B., Vuković, Z., Nikolić, M. V., Pavlović, V. B., Nikolic, J. R., Minic, D.,& Ristic, M. M.. (2008). Morphology investigation of mechanically activated ZnO-SnO2 system. in Ceramics International
Elsevier Sci Ltd, Oxford., 34(3), 639-643.
https://doi.org/10.1016/j.ceramint.2007.01.003

Ivetić TB, Vuković Z, Nikolić MV, Pavlović VB, Nikolic JR, Minic D, Ristic MM. Morphology investigation of mechanically activated ZnO-SnO2 system. in Ceramics International. 2008;34(3):639-643.
doi:10.1016/j.ceramint.2007.01.003 .

Ivetić, Tamara B., Vuković, Z., Nikolić, Maria Vesna, Pavlović, Vladimir B, Nikolic, J. R., Minic, Dragica, Ristic, M. M., "Morphology investigation of mechanically activated ZnO-SnO2 system" in Ceramics International, 34, no. 3 (2008):639-643,
https://doi.org/10.1016/j.ceramint.2007.01.003 . .

TY  - JOUR
AU  - Ivetić, Tamara B.
AU  - Nikolić, Maria Vesna
AU  - Slankamenac, Milos P
AU  - Živanov, M.
AU  - Minic, Dragica
AU  - Nikolić, Pantelija M.
AU  - Ristic, M. M.
PY  - 2007
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/183
AB  - The effects of small amounts (0.5; 1.0 and 1.5 mol. %) of bismuth oxide on the microstructure and electrical properties of ZnO-SnO2 ceramics have been studied. Starting powders of ZnO and SnO2 were mixed in the molar ratio 2:1. After adding Bi2O3 this mixture was mechanically activated for 10 minutes in a planetary ball mill, uniaxially pressed and sintered at 1300 degrees C for 2h. The phase composition of the sintered samples was analyzed by X-Ray Diffraction (ARD) and by Energy Dispersive Spectrometer (EDS). Morphologies were examined by Scanning Electron Microscopy (SEM). An ImpedancelGain Phase Analyzer (HP 4194A) was used to measure the impedance spectra (100Hz - 10MHz) at different temperatures. The electrical DC resistivity/conductivity at different temperatures was measured using a High Resistance Meter (HP 4329A).
PB  - Međunarodni Institut za nauku o sinterovanju, Beograd
T2  - Science of Sintering
T1  - Influence of Bi2O3 on microstructure and electrical properties of ZnO-SnO2 ceramics
EP  - 240
IS  - 3
SP  - 229
VL  - 39
DO  - 10.2298/SOS0703229I
ER  - 

@article{
author = "Ivetić, Tamara B. and Nikolić, Maria Vesna and Slankamenac, Milos P and Živanov, M. and Minic, Dragica and Nikolić, Pantelija M. and Ristic, M. M.",
year = "2007",
abstract = "The effects of small amounts (0.5; 1.0 and 1.5 mol. %) of bismuth oxide on the microstructure and electrical properties of ZnO-SnO2 ceramics have been studied. Starting powders of ZnO and SnO2 were mixed in the molar ratio 2:1. After adding Bi2O3 this mixture was mechanically activated for 10 minutes in a planetary ball mill, uniaxially pressed and sintered at 1300 degrees C for 2h. The phase composition of the sintered samples was analyzed by X-Ray Diffraction (ARD) and by Energy Dispersive Spectrometer (EDS). Morphologies were examined by Scanning Electron Microscopy (SEM). An ImpedancelGain Phase Analyzer (HP 4194A) was used to measure the impedance spectra (100Hz - 10MHz) at different temperatures. The electrical DC resistivity/conductivity at different temperatures was measured using a High Resistance Meter (HP 4329A).",
publisher = "Međunarodni Institut za nauku o sinterovanju, Beograd",
journal = "Science of Sintering",
title = "Influence of Bi2O3 on microstructure and electrical properties of ZnO-SnO2 ceramics",
pages = "240-229",
number = "3",
volume = "39",
doi = "10.2298/SOS0703229I"
}

Ivetić, T. B., Nikolić, M. V., Slankamenac, M. P., Živanov, M., Minic, D., Nikolić, P. M.,& Ristic, M. M.. (2007). Influence of Bi2O3 on microstructure and electrical properties of ZnO-SnO2 ceramics. in Science of Sintering
Međunarodni Institut za nauku o sinterovanju, Beograd., 39(3), 229-240.
https://doi.org/10.2298/SOS0703229I

Ivetić TB, Nikolić MV, Slankamenac MP, Živanov M, Minic D, Nikolić PM, Ristic MM. Influence of Bi2O3 on microstructure and electrical properties of ZnO-SnO2 ceramics. in Science of Sintering. 2007;39(3):229-240.
doi:10.2298/SOS0703229I .

Ivetić, Tamara B., Nikolić, Maria Vesna, Slankamenac, Milos P, Živanov, M., Minic, Dragica, Nikolić, Pantelija M., Ristic, M. M., "Influence of Bi2O3 on microstructure and electrical properties of ZnO-SnO2 ceramics" in Science of Sintering, 39, no. 3 (2007):229-240,
https://doi.org/10.2298/SOS0703229I . .