@article{
author = "Danilović Luković, Jelena and Goč, Sanja and Mitic, Ninoslav and Janković, Tamara",
year = "2022",
abstract = "The carbohydrate portion of proteins and lipids mediates a variety of biological processes. Revealing their
underlying principles is a challenging task that could contribute to a better understanding of many patho/physiological
conditions. On the other hand, the interest in extracellular vesicles (EVs) has increased in recent years due to their
involvement in intercellular communication leading to an array of functional and structural changes in recipient cells.
Their characterization uncovered an exceptional diversity in size, morphology, as well as in membrane and cargo content.
Monitoring/analysis of surface glycosylation of EVs originating from the prostate, termed prostasomes, revealed
their substantial contribution to the complexity of seminal plasma (SP) glycome. Heterogeneity of surface glycans confirm
the existence of several prostasome subpopulations. Presentation of surface glycans on prostasomal membrane is
strongly affected by co-localized membrane-associated glycoproteins and tetraspanins. They appear to be organized in
established/regular distribution patterns on membrane domains. Surface glycans are a component of EVs membrane
that affects its functionality and potentially a distinction marker of prostasome subpopulations. Further understanding
of the complex composition of glycans on EVs might explain the relation of their structure with functional alterations
in distinct patho/physiological conditions.",
publisher = "Faculty of Sciences, Department of Biology, University of Novi Sad, Serbia",
journal = "Biologia Serbica",
title = "Extracellular vesicles in a maze of glycomic complexity",
pages = "32-25",
number = "1",
volume = "44",
doi = "10.5281/zenodo.7075050"
}
