TY  - JOUR
AU  - Ajdzanović, Vladimir Z
AU  - Spasojević, Ivan
AU  - Sosic-Jurjević, Branka T
AU  - Filipović, Branko R
AU  - Trifunović, Svetlana L
AU  - Sekulic, Milka I
AU  - Milošević, Verica Lj.
PY  - 2011
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/482
AB  - A decrease of erythrocyte membrane fluidity can contribute to the pathophysiology of hypertension. Soy products, which are used as alternative therapeutics in some cardiovascular conditions, contain various isoflavones (genistein, daidzein, and their glucosides, genistin and daidzin), which can incorporate cellular membrane and change its fluidity. The aim of this study was to examine the effects of soy extract (which generally corresponds to the soy products of isoflavone composition) on erythrocyte membrane fluidity at graded depths. We used electron paramagnetic resonance spectroscopy and fatty acid spin probes (5-DS and 12-DS), the spectra of which are dependent on membrane fluidity. After being treated with soy extract, erythrocytes showed a significant (P = 0.016) decrease of membrane fluidity near the hydrophilic surface, while there were no significant changes of fluidity in deeper hydrophobic membrane regions. These results suggest that soy products containing high levels of genistein and isoflavone glucosides may not be suitable for use in hypertension because they decrease erythrocyte membrane fluidity.
PB  - Springer, New York
T2  - Journal of Membrane Biology
T1  - The Negative Effect of Soy Extract on Erythrocyte Membrane Fluidity: An Electron Paramagnetic Resonance Study
EP  - 135
IS  - 3
SP  - 131
VL  - 239
DO  - 10.1007/s00232-010-9332-8
ER  - 

@article{
author = "Ajdzanović, Vladimir Z and Spasojević, Ivan and Sosic-Jurjević, Branka T and Filipović, Branko R and Trifunović, Svetlana L and Sekulic, Milka I and Milošević, Verica Lj.",
year = "2011",
abstract = "A decrease of erythrocyte membrane fluidity can contribute to the pathophysiology of hypertension. Soy products, which are used as alternative therapeutics in some cardiovascular conditions, contain various isoflavones (genistein, daidzein, and their glucosides, genistin and daidzin), which can incorporate cellular membrane and change its fluidity. The aim of this study was to examine the effects of soy extract (which generally corresponds to the soy products of isoflavone composition) on erythrocyte membrane fluidity at graded depths. We used electron paramagnetic resonance spectroscopy and fatty acid spin probes (5-DS and 12-DS), the spectra of which are dependent on membrane fluidity. After being treated with soy extract, erythrocytes showed a significant (P = 0.016) decrease of membrane fluidity near the hydrophilic surface, while there were no significant changes of fluidity in deeper hydrophobic membrane regions. These results suggest that soy products containing high levels of genistein and isoflavone glucosides may not be suitable for use in hypertension because they decrease erythrocyte membrane fluidity.",
publisher = "Springer, New York",
journal = "Journal of Membrane Biology",
title = "The Negative Effect of Soy Extract on Erythrocyte Membrane Fluidity: An Electron Paramagnetic Resonance Study",
pages = "135-131",
number = "3",
volume = "239",
doi = "10.1007/s00232-010-9332-8"
}

Ajdzanović, V. Z., Spasojević, I., Sosic-Jurjević, B. T., Filipović, B. R., Trifunović, S. L., Sekulic, M. I.,& Milošević, V. Lj.. (2011). The Negative Effect of Soy Extract on Erythrocyte Membrane Fluidity: An Electron Paramagnetic Resonance Study. in Journal of Membrane Biology
Springer, New York., 239(3), 131-135.
https://doi.org/10.1007/s00232-010-9332-8

Ajdzanović VZ, Spasojević I, Sosic-Jurjević BT, Filipović BR, Trifunović SL, Sekulic MI, Milošević VL. The Negative Effect of Soy Extract on Erythrocyte Membrane Fluidity: An Electron Paramagnetic Resonance Study. in Journal of Membrane Biology. 2011;239(3):131-135.
doi:10.1007/s00232-010-9332-8 .

Ajdzanović, Vladimir Z, Spasojević, Ivan, Sosic-Jurjević, Branka T, Filipović, Branko R, Trifunović, Svetlana L, Sekulic, Milka I, Milošević, Verica Lj., "The Negative Effect of Soy Extract on Erythrocyte Membrane Fluidity: An Electron Paramagnetic Resonance Study" in Journal of Membrane Biology, 239, no. 3 (2011):131-135,
https://doi.org/10.1007/s00232-010-9332-8 . .