TY  - JOUR
AU  - Peric, Mina
AU  - Bataveljic, Danijela
AU  - Bijelic, Dunja
AU  - Milicević, Katarina
AU  - Andjus, Pavle R.
AU  - Bogdanović Pristov, Jelena
AU  - Nikolić, Ljiljana M.
PY  - 2022
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1546
AB  - We describe an approach for studying the physiology of single live cells using the conceptionally novel upright microscope/patch-clamp configuration. Electrophysiology experiments typically require a microscope with the fixed stage position and the motion control of the microscope objective. Here, we demonstrate that a microscope with a z-axis movable stage and a fixed objective can also be efficiently used in combination with the patch-clamp technique. We define a set of underlying principles governing the operation of this microscope/patch-clamp configuration and demonstrate its performance in practice using cultured astrocytes, microglia, and oligodendrocytes. Experimental results show that our custom configuration provides stable recordings, has a high success rate of the whole-cell patch-clamp trials, can be effectively applied to study cellular physiology of glial cells, and provides comparable performance and usability to the commercially available systems. Our system can be easily replicated or adapted to suit the needs of the research groups and can be cost-effective in reducing the investments in purchasing additional equipment. We provide step-by-step instructions on implementing an upright microscope with z-axis movable stage as a routine workhorse for patch-clamping.
PB  - Wiley, Hoboken
T2  - Microscopy Research and Technique
T1  - Approach for patch-clamping using an upright microscope with z-axis movable stage
DO  - 10.1002/jemt.24066
ER  - 

@article{
author = "Peric, Mina and Bataveljic, Danijela and Bijelic, Dunja and Milicević, Katarina and Andjus, Pavle R. and Bogdanović Pristov, Jelena and Nikolić, Ljiljana M.",
year = "2022",
abstract = "We describe an approach for studying the physiology of single live cells using the conceptionally novel upright microscope/patch-clamp configuration. Electrophysiology experiments typically require a microscope with the fixed stage position and the motion control of the microscope objective. Here, we demonstrate that a microscope with a z-axis movable stage and a fixed objective can also be efficiently used in combination with the patch-clamp technique. We define a set of underlying principles governing the operation of this microscope/patch-clamp configuration and demonstrate its performance in practice using cultured astrocytes, microglia, and oligodendrocytes. Experimental results show that our custom configuration provides stable recordings, has a high success rate of the whole-cell patch-clamp trials, can be effectively applied to study cellular physiology of glial cells, and provides comparable performance and usability to the commercially available systems. Our system can be easily replicated or adapted to suit the needs of the research groups and can be cost-effective in reducing the investments in purchasing additional equipment. We provide step-by-step instructions on implementing an upright microscope with z-axis movable stage as a routine workhorse for patch-clamping.",
publisher = "Wiley, Hoboken",
journal = "Microscopy Research and Technique",
title = "Approach for patch-clamping using an upright microscope with z-axis movable stage",
doi = "10.1002/jemt.24066"
}

Peric, M., Bataveljic, D., Bijelic, D., Milicević, K., Andjus, P. R., Bogdanović Pristov, J.,& Nikolić, L. M.. (2022). Approach for patch-clamping using an upright microscope with z-axis movable stage. in Microscopy Research and Technique
Wiley, Hoboken..
https://doi.org/10.1002/jemt.24066

Peric M, Bataveljic D, Bijelic D, Milicević K, Andjus PR, Bogdanović Pristov J, Nikolić LM. Approach for patch-clamping using an upright microscope with z-axis movable stage. in Microscopy Research and Technique. 2022;.
doi:10.1002/jemt.24066 .

Peric, Mina, Bataveljic, Danijela, Bijelic, Dunja, Milicević, Katarina, Andjus, Pavle R., Bogdanović Pristov, Jelena, Nikolić, Ljiljana M., "Approach for patch-clamping using an upright microscope with z-axis movable stage" in Microscopy Research and Technique (2022),
https://doi.org/10.1002/jemt.24066 . .

TY  - JOUR
AU  - Bogdanović Pristov, Jelena
AU  - Nikolić, Ljiljana M.
PY  - 2021
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1472
PB  - Wolters Kluwer Medknow Publications, Mumbai
T2  - Neural Regeneration Research
T1  - Light of the stars: calcium signals light up astrocytes in the presence of autoreactive CD4(+) T cells
EP  - 2396
IS  - 12
SP  - 2395
VL  - 16
DO  - 10.4103/1673-5374.313036
ER  - 

@article{
author = "Bogdanović Pristov, Jelena and Nikolić, Ljiljana M.",
year = "2021",
publisher = "Wolters Kluwer Medknow Publications, Mumbai",
journal = "Neural Regeneration Research",
title = "Light of the stars: calcium signals light up astrocytes in the presence of autoreactive CD4(+) T cells",
pages = "2396-2395",
number = "12",
volume = "16",
doi = "10.4103/1673-5374.313036"
}

Bogdanović Pristov, J.,& Nikolić, L. M.. (2021). Light of the stars: calcium signals light up astrocytes in the presence of autoreactive CD4(+) T cells. in Neural Regeneration Research
Wolters Kluwer Medknow Publications, Mumbai., 16(12), 2395-2396.
https://doi.org/10.4103/1673-5374.313036

Bogdanović Pristov J, Nikolić LM. Light of the stars: calcium signals light up astrocytes in the presence of autoreactive CD4(+) T cells. in Neural Regeneration Research. 2021;16(12):2395-2396.
doi:10.4103/1673-5374.313036 .

Bogdanović Pristov, Jelena, Nikolić, Ljiljana M., "Light of the stars: calcium signals light up astrocytes in the presence of autoreactive CD4(+) T cells" in Neural Regeneration Research, 16, no. 12 (2021):2395-2396,
https://doi.org/10.4103/1673-5374.313036 . .

TY  - JOUR
AU  - Korać Jačić, Jelena
AU  - Nikolić, Ljiljana M.
AU  - Stanković, Dalibor M.
AU  - Opačić, Miloš
AU  - Dimitrijević, Milena
AU  - Savić, Danijela Z
AU  - Grguric-Sipka, Sanja
AU  - Spasojević, Ivan
AU  - Bogdanović Pristov, Jelena
PY  - 2020
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1344
AB  - Upon release in response to stress, epinephrine (Epi) may interact with labile iron pool in human plasma with potentially important (patho)physiological consequences. We have shown that Epi and Fe3+ build stable 1:1 high-spin bidentate complex at physiological pH, and that Epi does not undergo degradation in the presence of iron. However, the interactions of Epi with the more soluble Fe2+, and the impact of iron on biological activity of Epi are still not known. Herein we showed that Epi and Fe2+ build colorless complex which is stable under anaerobic conditions. In the presence of O-2, Epi promoted the oxidation of Fe2+ and the formation of Epi-Fe3+ complex. Cyclic voltammetry showed that mid-point potential of Epi-Fe2+ complex is very low (-582 mV vs. standard hydrogen electrode), which explains catalyzed oxidation of Fe2+. Next, we examined the impact of iron binding on biological performance of Epi using patch clamping in cell culture with constitutive expression of adrenergic receptors. Epi alone evoked an increase of outward currents, whereas Epi in the complex with Fe3+ did not. This implies that the binding of Epi to adrenergic receptors and their activation is prevented by the formation of complex with iron. Pro-oxidative activity of Epi-Fe2+ complex may represent a link between chronic stress and cardiovascular problems. On the other hand, labile iron could serve as a modulator of biological activity of ligands. Such interactions may be important in human pathologies that are related to iron overload or deficiency.
PB  - Elsevier Science Inc, New York
T2  - Free Radical Biology and Medicine
T1  - Ferrous iron binding to epinephrine promotes the oxidation of iron and impedes activation of adrenergic receptors
EP  - 127
SP  - 123
VL  - 148
DO  - 10.1016/j.freeradbiomed.2020.01.001
ER  - 

@article{
author = "Korać Jačić, Jelena and Nikolić, Ljiljana M. and Stanković, Dalibor M. and Opačić, Miloš and Dimitrijević, Milena and Savić, Danijela Z and Grguric-Sipka, Sanja and Spasojević, Ivan and Bogdanović Pristov, Jelena",
year = "2020",
abstract = "Upon release in response to stress, epinephrine (Epi) may interact with labile iron pool in human plasma with potentially important (patho)physiological consequences. We have shown that Epi and Fe3+ build stable 1:1 high-spin bidentate complex at physiological pH, and that Epi does not undergo degradation in the presence of iron. However, the interactions of Epi with the more soluble Fe2+, and the impact of iron on biological activity of Epi are still not known. Herein we showed that Epi and Fe2+ build colorless complex which is stable under anaerobic conditions. In the presence of O-2, Epi promoted the oxidation of Fe2+ and the formation of Epi-Fe3+ complex. Cyclic voltammetry showed that mid-point potential of Epi-Fe2+ complex is very low (-582 mV vs. standard hydrogen electrode), which explains catalyzed oxidation of Fe2+. Next, we examined the impact of iron binding on biological performance of Epi using patch clamping in cell culture with constitutive expression of adrenergic receptors. Epi alone evoked an increase of outward currents, whereas Epi in the complex with Fe3+ did not. This implies that the binding of Epi to adrenergic receptors and their activation is prevented by the formation of complex with iron. Pro-oxidative activity of Epi-Fe2+ complex may represent a link between chronic stress and cardiovascular problems. On the other hand, labile iron could serve as a modulator of biological activity of ligands. Such interactions may be important in human pathologies that are related to iron overload or deficiency.",
publisher = "Elsevier Science Inc, New York",
journal = "Free Radical Biology and Medicine",
title = "Ferrous iron binding to epinephrine promotes the oxidation of iron and impedes activation of adrenergic receptors",
pages = "127-123",
volume = "148",
doi = "10.1016/j.freeradbiomed.2020.01.001"
}

Korać Jačić, J., Nikolić, L. M., Stanković, D. M., Opačić, M., Dimitrijević, M., Savić, D. Z., Grguric-Sipka, S., Spasojević, I.,& Bogdanović Pristov, J.. (2020). Ferrous iron binding to epinephrine promotes the oxidation of iron and impedes activation of adrenergic receptors. in Free Radical Biology and Medicine
Elsevier Science Inc, New York., 148, 123-127.
https://doi.org/10.1016/j.freeradbiomed.2020.01.001

Korać Jačić J, Nikolić LM, Stanković DM, Opačić M, Dimitrijević M, Savić DZ, Grguric-Sipka S, Spasojević I, Bogdanović Pristov J. Ferrous iron binding to epinephrine promotes the oxidation of iron and impedes activation of adrenergic receptors. in Free Radical Biology and Medicine. 2020;148:123-127.
doi:10.1016/j.freeradbiomed.2020.01.001 .

Korać Jačić, Jelena, Nikolić, Ljiljana M., Stanković, Dalibor M., Opačić, Miloš, Dimitrijević, Milena, Savić, Danijela Z, Grguric-Sipka, Sanja, Spasojević, Ivan, Bogdanović Pristov, Jelena, "Ferrous iron binding to epinephrine promotes the oxidation of iron and impedes activation of adrenergic receptors" in Free Radical Biology and Medicine, 148 (2020):123-127,
https://doi.org/10.1016/j.freeradbiomed.2020.01.001 . .

TY  - JOUR
AU  - Bijelic, Dunja D.
AU  - Milicević, Katarina
AU  - Lazarević, Milica N.
AU  - Miljković, Đorđe
AU  - Bogdanović Pristov, Jelena
AU  - Savić, Danijela Z
AU  - Petković, Branka
AU  - Andjus, Pavle R.
AU  - Momcilović, Miljana
AU  - Nikolić, Ljiljana M.
PY  - 2020
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1317
AB  - Interaction between autoreactive immune cells and astroglia is an important part of the pathologic processes that fuel neurodegeneration in multiple sclerosis. In this inflammatory disease, immune cells enter into the central nervous system (CNS) and they spread through CNS parenchyma, but the impact of these autoreactive immune cells on the activity pattern of astrocytes has not been defined. By exploiting naive astrocytes in culture and CNS-infiltrated immune cells (CNS IICs) isolated from rat with experimental autoimmune encephalomyelitis (EAE), here we demonstrate previously unrecognized properties of immune cell-astrocyte interaction. We show that CNS IICs but not the peripheral immune cell application, evokes a rapid and vigorous intracellular Ca(2+)increase in astrocytes by promoting glial release of ATP. ATP propagated Ca(2+)elevation through glial purinergic P2X7 receptor activation by the hemichannel-dependent nucleotide release mechanism. Astrocyte Ca(2+)increase is specifically triggered by the autoreactive CD4(+)T-cell application and these two cell types exhibit close spatial interaction in EAE. Therefore, Ca(2+)signals may mediate a rapid astroglial response to the autoreactive immune cells in their local environment. This property of immune cell-astrocyte interaction may be important to consider in studies interrogating CNS autoimmune disease.
PB  - Wiley, Hoboken
T2  - Journal of Neuroscience Research
T1  - Central nervous system-infiltrated immune cells induce calcium increase in astrocytes via astroglial purinergic signaling
EP  - 2332
IS  - 11
SP  - 2317
VL  - 98
DO  - 10.1002/jnr.24699
ER  - 

@article{
author = "Bijelic, Dunja D. and Milicević, Katarina and Lazarević, Milica N. and Miljković, Đorđe and Bogdanović Pristov, Jelena and Savić, Danijela Z and Petković, Branka and Andjus, Pavle R. and Momcilović, Miljana and Nikolić, Ljiljana M.",
year = "2020",
abstract = "Interaction between autoreactive immune cells and astroglia is an important part of the pathologic processes that fuel neurodegeneration in multiple sclerosis. In this inflammatory disease, immune cells enter into the central nervous system (CNS) and they spread through CNS parenchyma, but the impact of these autoreactive immune cells on the activity pattern of astrocytes has not been defined. By exploiting naive astrocytes in culture and CNS-infiltrated immune cells (CNS IICs) isolated from rat with experimental autoimmune encephalomyelitis (EAE), here we demonstrate previously unrecognized properties of immune cell-astrocyte interaction. We show that CNS IICs but not the peripheral immune cell application, evokes a rapid and vigorous intracellular Ca(2+)increase in astrocytes by promoting glial release of ATP. ATP propagated Ca(2+)elevation through glial purinergic P2X7 receptor activation by the hemichannel-dependent nucleotide release mechanism. Astrocyte Ca(2+)increase is specifically triggered by the autoreactive CD4(+)T-cell application and these two cell types exhibit close spatial interaction in EAE. Therefore, Ca(2+)signals may mediate a rapid astroglial response to the autoreactive immune cells in their local environment. This property of immune cell-astrocyte interaction may be important to consider in studies interrogating CNS autoimmune disease.",
publisher = "Wiley, Hoboken",
journal = "Journal of Neuroscience Research",
title = "Central nervous system-infiltrated immune cells induce calcium increase in astrocytes via astroglial purinergic signaling",
pages = "2332-2317",
number = "11",
volume = "98",
doi = "10.1002/jnr.24699"
}

Bijelic, D. D., Milicević, K., Lazarević, M. N., Miljković, Đ., Bogdanović Pristov, J., Savić, D. Z., Petković, B., Andjus, P. R., Momcilović, M.,& Nikolić, L. M.. (2020). Central nervous system-infiltrated immune cells induce calcium increase in astrocytes via astroglial purinergic signaling. in Journal of Neuroscience Research
Wiley, Hoboken., 98(11), 2317-2332.
https://doi.org/10.1002/jnr.24699

Bijelic DD, Milicević K, Lazarević MN, Miljković Đ, Bogdanović Pristov J, Savić DZ, Petković B, Andjus PR, Momcilović M, Nikolić LM. Central nervous system-infiltrated immune cells induce calcium increase in astrocytes via astroglial purinergic signaling. in Journal of Neuroscience Research. 2020;98(11):2317-2332.
doi:10.1002/jnr.24699 .

Bijelic, Dunja D., Milicević, Katarina, Lazarević, Milica N., Miljković, Đorđe, Bogdanović Pristov, Jelena, Savić, Danijela Z, Petković, Branka, Andjus, Pavle R., Momcilović, Miljana, Nikolić, Ljiljana M., "Central nervous system-infiltrated immune cells induce calcium increase in astrocytes via astroglial purinergic signaling" in Journal of Neuroscience Research, 98, no. 11 (2020):2317-2332,
https://doi.org/10.1002/jnr.24699 . .

TY  - CONF
AU  - Spasić, Slađana
AU  - Nikolić, Ljiljana
AU  - Mutavdžić, Dragosav
AU  - Kartelija, Gordana
AU  - Todorović, Dajana
PY  - 2019
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/2950
PB  - Belgrade: Serbian Physiological Society
C3  - Second Congress of Physiological Sciences of Serbia with International Participation “Current Trends in Physiological Sciences”
T1  - Effect of static magnetic field on fractal complexity on spontaneous neuronal activity in snail
SP  - 180
UR  - https://hdl.handle.net/21.15107/rcub_rimsi_2950
ER  - 

@conference{
author = "Spasić, Slađana and Nikolić, Ljiljana and Mutavdžić, Dragosav and Kartelija, Gordana and Todorović, Dajana",
year = "2019",
publisher = "Belgrade: Serbian Physiological Society",
journal = "Second Congress of Physiological Sciences of Serbia with International Participation “Current Trends in Physiological Sciences”",
title = "Effect of static magnetic field on fractal complexity on spontaneous neuronal activity in snail",
pages = "180",
url = "https://hdl.handle.net/21.15107/rcub_rimsi_2950"
}

Spasić, S., Nikolić, L., Mutavdžić, D., Kartelija, G.,& Todorović, D.. (2019). Effect of static magnetic field on fractal complexity on spontaneous neuronal activity in snail. in Second Congress of Physiological Sciences of Serbia with International Participation “Current Trends in Physiological Sciences”
Belgrade: Serbian Physiological Society., 180.
https://hdl.handle.net/21.15107/rcub_rimsi_2950

Spasić S, Nikolić L, Mutavdžić D, Kartelija G, Todorović D. Effect of static magnetic field on fractal complexity on spontaneous neuronal activity in snail. in Second Congress of Physiological Sciences of Serbia with International Participation “Current Trends in Physiological Sciences”. 2019;:180.
https://hdl.handle.net/21.15107/rcub_rimsi_2950 .

Spasić, Slađana, Nikolić, Ljiljana, Mutavdžić, Dragosav, Kartelija, Gordana, Todorović, Dajana, "Effect of static magnetic field on fractal complexity on spontaneous neuronal activity in snail" in Second Congress of Physiological Sciences of Serbia with International Participation “Current Trends in Physiological Sciences” (2019):180,
https://hdl.handle.net/21.15107/rcub_rimsi_2950 .

TY  - JOUR
AU  - Krizak, Strahinja
AU  - Nikolić, Ljiljana
AU  - Stanić, Marina
AU  - Žižić, Milan
AU  - Zakrzewska, Joanna
AU  - Zivić, Miroslav
AU  - Todorović, Nataša
PY  - 2015
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/869
AB  - We describe here whole-cell currents of droplets prepared from the apical region of growing Phycomyces blakesleeanus sporangiophores. Whole-cell current recordings revealed the osmotically activated, outwardly rectifying, fast inactivating instantaneous current (ORIC) with biophysical properties closely resembling volume-regulated anionic current (VRAC). ORIC is activated under conditions of osmotically induced swelling and shows strong selectivity for anions over cations. In addition, ORIC shows voltage and time-dependent inactivation at positive potentials and recovery from inactivation at negative potentials. ORIC is blocked by anthracene-9-carboxylic acid, an anion channel blocker, in a voltage-dependent manner. This is the first report of the presence of VRAC-like current in an organism outside the chordate lineage.
PB  - Elsevier, Amsterdam
T2  - Research in Microbiology
T1  - Osmotic swelling activates a novel anionic current with VRAC-like properties in a cytoplasmic droplet membrane from Phycomyces blakesleeanus sporangiophores
EP  - 173
IS  - 3
SP  - 162
VL  - 166
DO  - 10.1016/j.resmic.2015.02.004
ER  - 

@article{
author = "Krizak, Strahinja and Nikolić, Ljiljana and Stanić, Marina and Žižić, Milan and Zakrzewska, Joanna and Zivić, Miroslav and Todorović, Nataša",
year = "2015",
abstract = "We describe here whole-cell currents of droplets prepared from the apical region of growing Phycomyces blakesleeanus sporangiophores. Whole-cell current recordings revealed the osmotically activated, outwardly rectifying, fast inactivating instantaneous current (ORIC) with biophysical properties closely resembling volume-regulated anionic current (VRAC). ORIC is activated under conditions of osmotically induced swelling and shows strong selectivity for anions over cations. In addition, ORIC shows voltage and time-dependent inactivation at positive potentials and recovery from inactivation at negative potentials. ORIC is blocked by anthracene-9-carboxylic acid, an anion channel blocker, in a voltage-dependent manner. This is the first report of the presence of VRAC-like current in an organism outside the chordate lineage.",
publisher = "Elsevier, Amsterdam",
journal = "Research in Microbiology",
title = "Osmotic swelling activates a novel anionic current with VRAC-like properties in a cytoplasmic droplet membrane from Phycomyces blakesleeanus sporangiophores",
pages = "173-162",
number = "3",
volume = "166",
doi = "10.1016/j.resmic.2015.02.004"
}

Krizak, S., Nikolić, L., Stanić, M., Žižić, M., Zakrzewska, J., Zivić, M.,& Todorović, N.. (2015). Osmotic swelling activates a novel anionic current with VRAC-like properties in a cytoplasmic droplet membrane from Phycomyces blakesleeanus sporangiophores. in Research in Microbiology
Elsevier, Amsterdam., 166(3), 162-173.
https://doi.org/10.1016/j.resmic.2015.02.004

Krizak S, Nikolić L, Stanić M, Žižić M, Zakrzewska J, Zivić M, Todorović N. Osmotic swelling activates a novel anionic current with VRAC-like properties in a cytoplasmic droplet membrane from Phycomyces blakesleeanus sporangiophores. in Research in Microbiology. 2015;166(3):162-173.
doi:10.1016/j.resmic.2015.02.004 .

Krizak, Strahinja, Nikolić, Ljiljana, Stanić, Marina, Žižić, Milan, Zakrzewska, Joanna, Zivić, Miroslav, Todorović, Nataša, "Osmotic swelling activates a novel anionic current with VRAC-like properties in a cytoplasmic droplet membrane from Phycomyces blakesleeanus sporangiophores" in Research in Microbiology, 166, no. 3 (2015):162-173,
https://doi.org/10.1016/j.resmic.2015.02.004 . .

TY  - JOUR
AU  - Kalauzi, Aleksandar
AU  - Nikolić, Ljiljana M.
AU  - Savić, Danijela Z
AU  - Radotić, Ksenija
PY  - 2015
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/897
AB  - The physiological and biochemical factors that lead to cell death have not been recognized completely. To our knowledge, there are no data on the bioelectric parameters that characterize early period of cell death, as well as on the appearance of related membrane current frequencies. We studied early parameters of glutaraldehyde (GA)-induced cell death, by examining the membrane properties of mouse microglia using the whole-cell patch-clamp technique. In addition, we investigated the GA-induced changes in the membrane current frequency, to see if characteristic frequencies would appear in dying cell. For data analysis, we applied a new approach, an improved multiple moving window length analysis and interval weighted spectra averaging (IWSA). We chose GA for its ability to induce almost instantaneous cell death. The 0.6 % GA did not induce changes in the bioelectric membrane properties of microglia. However, the 3 % GA caused significant decrease of membrane capacitance and resistance accompanied by the prominent increase in the membrane currents and nearly ohmic current response of microglial cells. These data indicate that 3 % GA caused complete loss of the membrane function consequently inducing instantaneous cell death. The membrane function loss was characterized by appearance of the 1.26-4.62 Hz frequency peak in the IWSA spectra, while no significant increase of amplitudes could be observed for cells treated with 0.6 % GA. To our knowledge, this is the first record of a frequency associated with complete loss of the membrane function and thus can be considered as an early indicator of cell death.
PB  - Springer, New York
T2  - Journal of Membrane Biology
T1  - Cell Death Parameters as Revealed by Whole-Cell Patch-Clamp and Interval Weighted Spectra Averaging: Changes in Membrane Properties and Current Frequency of Cultured Mouse Microglial Cells Induced by Glutaraldehyde
EP  - 123
IS  - 1
SP  - 117
VL  - 248
DO  - 10.1007/s00232-014-9748-7
ER  - 

@article{
author = "Kalauzi, Aleksandar and Nikolić, Ljiljana M. and Savić, Danijela Z and Radotić, Ksenija",
year = "2015",
abstract = "The physiological and biochemical factors that lead to cell death have not been recognized completely. To our knowledge, there are no data on the bioelectric parameters that characterize early period of cell death, as well as on the appearance of related membrane current frequencies. We studied early parameters of glutaraldehyde (GA)-induced cell death, by examining the membrane properties of mouse microglia using the whole-cell patch-clamp technique. In addition, we investigated the GA-induced changes in the membrane current frequency, to see if characteristic frequencies would appear in dying cell. For data analysis, we applied a new approach, an improved multiple moving window length analysis and interval weighted spectra averaging (IWSA). We chose GA for its ability to induce almost instantaneous cell death. The 0.6 % GA did not induce changes in the bioelectric membrane properties of microglia. However, the 3 % GA caused significant decrease of membrane capacitance and resistance accompanied by the prominent increase in the membrane currents and nearly ohmic current response of microglial cells. These data indicate that 3 % GA caused complete loss of the membrane function consequently inducing instantaneous cell death. The membrane function loss was characterized by appearance of the 1.26-4.62 Hz frequency peak in the IWSA spectra, while no significant increase of amplitudes could be observed for cells treated with 0.6 % GA. To our knowledge, this is the first record of a frequency associated with complete loss of the membrane function and thus can be considered as an early indicator of cell death.",
publisher = "Springer, New York",
journal = "Journal of Membrane Biology",
title = "Cell Death Parameters as Revealed by Whole-Cell Patch-Clamp and Interval Weighted Spectra Averaging: Changes in Membrane Properties and Current Frequency of Cultured Mouse Microglial Cells Induced by Glutaraldehyde",
pages = "123-117",
number = "1",
volume = "248",
doi = "10.1007/s00232-014-9748-7"
}

Kalauzi, A., Nikolić, L. M., Savić, D. Z.,& Radotić, K.. (2015). Cell Death Parameters as Revealed by Whole-Cell Patch-Clamp and Interval Weighted Spectra Averaging: Changes in Membrane Properties and Current Frequency of Cultured Mouse Microglial Cells Induced by Glutaraldehyde. in Journal of Membrane Biology
Springer, New York., 248(1), 117-123.
https://doi.org/10.1007/s00232-014-9748-7

Kalauzi A, Nikolić LM, Savić DZ, Radotić K. Cell Death Parameters as Revealed by Whole-Cell Patch-Clamp and Interval Weighted Spectra Averaging: Changes in Membrane Properties and Current Frequency of Cultured Mouse Microglial Cells Induced by Glutaraldehyde. in Journal of Membrane Biology. 2015;248(1):117-123.
doi:10.1007/s00232-014-9748-7 .

Kalauzi, Aleksandar, Nikolić, Ljiljana M., Savić, Danijela Z, Radotić, Ksenija, "Cell Death Parameters as Revealed by Whole-Cell Patch-Clamp and Interval Weighted Spectra Averaging: Changes in Membrane Properties and Current Frequency of Cultured Mouse Microglial Cells Induced by Glutaraldehyde" in Journal of Membrane Biology, 248, no. 1 (2015):117-123,
https://doi.org/10.1007/s00232-014-9748-7 . .

TY  - JOUR
AU  - Kesić, Srđan Ž.
AU  - Nikolić, Ljiljana
AU  - Janać, Branka
AU  - Spasić, Slađana
PY  - 2014
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/2398
AB  - The components of complex bioelectrical activity – action potential (AP), interspike interval (ISI) and the quiet interburst interval (IBI), along with the effects of 2.7 mT and 10 mT static magnetic fields, were identified and examined in the spontaneously active Br neuron of the subesophageal ganglion complex of the garden snail Helix pomatia by fractal analysis using Higuchi’s fractal dimension (FD). The normalized mean of the empirical FD distributions of bursting activity of the Br neuron were formed under different experimental conditions: before (Control), during (MF), and after exposure to the static magnetic field (AMF). Using the fractal analysis method for the first time, a separation of the AP, ISI and IBI components was successfully achieved. Our results show that fractal analysis with deconvolution of the normalized mean of the empirical FD distributions into Gaussian functions is a useful tool for revealing the effects of magnetic fields on the complexity of neuronal bioelectric activity and its AP, ISI and IBI components.
PB  - Serbian Biological Society
PB  - Institute for Biological Research "Siniša Stanković", Serbia
PB  - Serbian Biological Society, Institute for BFaculty of Biology, University of Belgrade
PB  - Department of Biology and Ecology, Faculty of Science, University of Novi Sad
PB  - Institute for the Application of Nuclear Energy
T2  - Archives of Biological Sciences
T1  - Using Higuchi’s fractal dimension in fine analysis of the effects of 2.7 mT and 10 mT static magnetic fields on the complex bursting activity of the snail BR neuron
EP  - 572
IS  - 2
SP  - 563
VL  - 66
DO  - 10.2298/ABS1402563K
ER  - 

@article{
author = "Kesić, Srđan Ž. and Nikolić, Ljiljana and Janać, Branka and Spasić, Slađana",
year = "2014",
abstract = "The components of complex bioelectrical activity – action potential (AP), interspike interval (ISI) and the quiet interburst interval (IBI), along with the effects of 2.7 mT and 10 mT static magnetic fields, were identified and examined in the spontaneously active Br neuron of the subesophageal ganglion complex of the garden snail Helix pomatia by fractal analysis using Higuchi’s fractal dimension (FD). The normalized mean of the empirical FD distributions of bursting activity of the Br neuron were formed under different experimental conditions: before (Control), during (MF), and after exposure to the static magnetic field (AMF). Using the fractal analysis method for the first time, a separation of the AP, ISI and IBI components was successfully achieved. Our results show that fractal analysis with deconvolution of the normalized mean of the empirical FD distributions into Gaussian functions is a useful tool for revealing the effects of magnetic fields on the complexity of neuronal bioelectric activity and its AP, ISI and IBI components.",
publisher = "Serbian Biological Society, Institute for Biological Research "Siniša Stanković", Serbia, Serbian Biological Society, Institute for BFaculty of Biology, University of Belgrade, Department of Biology and Ecology, Faculty of Science, University of Novi Sad, Institute for the Application of Nuclear Energy",
journal = "Archives of Biological Sciences",
title = "Using Higuchi’s fractal dimension in fine analysis of the effects of 2.7 mT and 10 mT static magnetic fields on the complex bursting activity of the snail BR neuron",
pages = "572-563",
number = "2",
volume = "66",
doi = "10.2298/ABS1402563K"
}

Kesić, S. Ž., Nikolić, L., Janać, B.,& Spasić, S.. (2014). Using Higuchi’s fractal dimension in fine analysis of the effects of 2.7 mT and 10 mT static magnetic fields on the complex bursting activity of the snail BR neuron. in Archives of Biological Sciences
Serbian Biological Society., 66(2), 563-572.
https://doi.org/10.2298/ABS1402563K

Kesić SŽ, Nikolić L, Janać B, Spasić S. Using Higuchi’s fractal dimension in fine analysis of the effects of 2.7 mT and 10 mT static magnetic fields on the complex bursting activity of the snail BR neuron. in Archives of Biological Sciences. 2014;66(2):563-572.
doi:10.2298/ABS1402563K .

Kesić, Srđan Ž., Nikolić, Ljiljana, Janać, Branka, Spasić, Slađana, "Using Higuchi’s fractal dimension in fine analysis of the effects of 2.7 mT and 10 mT static magnetic fields on the complex bursting activity of the snail BR neuron" in Archives of Biological Sciences, 66, no. 2 (2014):563-572,
https://doi.org/10.2298/ABS1402563K . .

TY  - JOUR
AU  - Kesic, Srdjan
AU  - Nikolić, Ljiljana M.
AU  - Savić, Aleksandar G
AU  - Petković, Branka
AU  - Spasić, Slađana
PY  - 2014
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/786
AB  - Aim of this study was to investigate the application of normalized mean of the empirical Higuchi fractal dimension (FD) distributions, as a new approach to analyze the spontaneous bioelectrical activity of garden snail (Helix pomatia) Br neuron. The effect of ouabain on modulation of Br neuron bursting activity before and after the exposure to 10 mT static magnetic field (SMF) was observed by analyzing the following parameters: action potential (AP), interspike interval (ISI) and interbursting interval (IBI) components. Normalized mean of the empirical FD distributions were formed for the following experimental conditions: Control 1, Ouabain 1, Control 2, SMF 2, ASMF 2, Control 3, SMF 3 and Ouabain ASMF 3. Our main results have shown that ouabain without SMF induced increase in participation of AP and a decrease in participation of IBI components compared to the first control condition. However, in the presence of 10 mT SMF, ouabain-induced changes of measured parameters of Br neuron activity were less pronounced compared to the third control condition. We have shown that normalized mean of the empirical FD distributions is a useful method for detecting the changes in AP, ISI, and IBI components of complex bursting activity in altered physiological states.
PB  - General Physiol And Biophysics, Bratislava
T2  - General Physiology and Biophysics
T1  - Ouabain modulation of snail Br neuron bursting activity after the exposure to 10 mT static magnetic field revealed by Higuchi fractal dimension
EP  - 344
IS  - 3
SP  - 335
VL  - 33
DO  - 10.4149/gpb_2014010
ER  - 

@article{
author = "Kesic, Srdjan and Nikolić, Ljiljana M. and Savić, Aleksandar G and Petković, Branka and Spasić, Slađana",
year = "2014",
abstract = "Aim of this study was to investigate the application of normalized mean of the empirical Higuchi fractal dimension (FD) distributions, as a new approach to analyze the spontaneous bioelectrical activity of garden snail (Helix pomatia) Br neuron. The effect of ouabain on modulation of Br neuron bursting activity before and after the exposure to 10 mT static magnetic field (SMF) was observed by analyzing the following parameters: action potential (AP), interspike interval (ISI) and interbursting interval (IBI) components. Normalized mean of the empirical FD distributions were formed for the following experimental conditions: Control 1, Ouabain 1, Control 2, SMF 2, ASMF 2, Control 3, SMF 3 and Ouabain ASMF 3. Our main results have shown that ouabain without SMF induced increase in participation of AP and a decrease in participation of IBI components compared to the first control condition. However, in the presence of 10 mT SMF, ouabain-induced changes of measured parameters of Br neuron activity were less pronounced compared to the third control condition. We have shown that normalized mean of the empirical FD distributions is a useful method for detecting the changes in AP, ISI, and IBI components of complex bursting activity in altered physiological states.",
publisher = "General Physiol And Biophysics, Bratislava",
journal = "General Physiology and Biophysics",
title = "Ouabain modulation of snail Br neuron bursting activity after the exposure to 10 mT static magnetic field revealed by Higuchi fractal dimension",
pages = "344-335",
number = "3",
volume = "33",
doi = "10.4149/gpb_2014010"
}

Kesic, S., Nikolić, L. M., Savić, A. G., Petković, B.,& Spasić, S.. (2014). Ouabain modulation of snail Br neuron bursting activity after the exposure to 10 mT static magnetic field revealed by Higuchi fractal dimension. in General Physiology and Biophysics
General Physiol And Biophysics, Bratislava., 33(3), 335-344.
https://doi.org/10.4149/gpb_2014010

Kesic S, Nikolić LM, Savić AG, Petković B, Spasić S. Ouabain modulation of snail Br neuron bursting activity after the exposure to 10 mT static magnetic field revealed by Higuchi fractal dimension. in General Physiology and Biophysics. 2014;33(3):335-344.
doi:10.4149/gpb_2014010 .

Kesic, Srdjan, Nikolić, Ljiljana M., Savić, Aleksandar G, Petković, Branka, Spasić, Slađana, "Ouabain modulation of snail Br neuron bursting activity after the exposure to 10 mT static magnetic field revealed by Higuchi fractal dimension" in General Physiology and Biophysics, 33, no. 3 (2014):335-344,
https://doi.org/10.4149/gpb_2014010 . .

TY  - JOUR
AU  - Kesic, S.
AU  - Nikolić, Ljiljana M.
AU  - Janac, Branka
AU  - Spasić, Slađana
PY  - 2014
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/767
AB  - The components of complex bioelectrical activity - action potential (AP), interspike interval (ISI) and the quiet interburst interval (IBI), along with the effects of 2.7 mT and 10 mT static magnetic fields, were identified and examined in the spontaneously active Br neuron of the subesophageal ganglion complex of the garden snail Helix pomatia by fractal analysis using Higuchi's fractal dimension (FD). The normalized mean of the empirical FD distributions of bursting activity of the Br neuron were formed under different experimental conditions: before (Control), during (MF), and after exposure to the static magnetic field (AMF). Using the fractal analysis method for the first time, a separation of the AP, ISI and IBI components was successfully achieved. Our results show that fractal analysis with deconvolution of the normalized mean of the empirical FD distributions into Gaussian functions is a useful tool for revealing the effects of magnetic fields on the complexity of neuronal bioelectric activity and its AP, ISI and IBI components.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - Using Higuchi’s fractal dimension in fine analysis of the effects of 2.7 mt and 10 mt static magnetic fields on the complex bursting activity of the snail br neuron
EP  - 572
IS  - 2
SP  - 563
VL  - 66
DO  - 10.2298/ABS1402563K
ER  - 

@article{
author = "Kesic, S. and Nikolić, Ljiljana M. and Janac, Branka and Spasić, Slađana",
year = "2014",
abstract = "The components of complex bioelectrical activity - action potential (AP), interspike interval (ISI) and the quiet interburst interval (IBI), along with the effects of 2.7 mT and 10 mT static magnetic fields, were identified and examined in the spontaneously active Br neuron of the subesophageal ganglion complex of the garden snail Helix pomatia by fractal analysis using Higuchi's fractal dimension (FD). The normalized mean of the empirical FD distributions of bursting activity of the Br neuron were formed under different experimental conditions: before (Control), during (MF), and after exposure to the static magnetic field (AMF). Using the fractal analysis method for the first time, a separation of the AP, ISI and IBI components was successfully achieved. Our results show that fractal analysis with deconvolution of the normalized mean of the empirical FD distributions into Gaussian functions is a useful tool for revealing the effects of magnetic fields on the complexity of neuronal bioelectric activity and its AP, ISI and IBI components.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Using Higuchi’s fractal dimension in fine analysis of the effects of 2.7 mt and 10 mt static magnetic fields on the complex bursting activity of the snail br neuron",
pages = "572-563",
number = "2",
volume = "66",
doi = "10.2298/ABS1402563K"
}

Kesic, S., Nikolić, L. M., Janac, B.,& Spasić, S.. (2014). Using Higuchi’s fractal dimension in fine analysis of the effects of 2.7 mt and 10 mt static magnetic fields on the complex bursting activity of the snail br neuron. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 66(2), 563-572.
https://doi.org/10.2298/ABS1402563K

Kesic S, Nikolić LM, Janac B, Spasić S. Using Higuchi’s fractal dimension in fine analysis of the effects of 2.7 mt and 10 mt static magnetic fields on the complex bursting activity of the snail br neuron. in Archives of Biological Sciences. 2014;66(2):563-572.
doi:10.2298/ABS1402563K .

Kesic, S., Nikolić, Ljiljana M., Janac, Branka, Spasić, Slađana, "Using Higuchi’s fractal dimension in fine analysis of the effects of 2.7 mt and 10 mt static magnetic fields on the complex bursting activity of the snail br neuron" in Archives of Biological Sciences, 66, no. 2 (2014):563-572,
https://doi.org/10.2298/ABS1402563K . .

TY  - JOUR
AU  - Nikolić, Ljiljana M.
AU  - Todorović, Nataša
AU  - Zakrzewska, Joanna
AU  - Stanić, Marina
AU  - Raus, Snežana Z
AU  - Kalauzi, Aleksandar
AU  - Janac, Branka B
PY  - 2012
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/539
AB  - The spontaneously active Br neuron from the brain-subesophageal ganglion complex of the garden snail Helix pomatia rhythmically generates regular bursts of action potentials with quiescent intervals accompanied by slow oscillations of membrane potential. We examined the involvement of the Na+/K+ pump in modulating its bursting activity by applying a static magnetic field. Whole snail brains and Br neuron were exposed to the 10-mT static magnetic field for 15 min. Biochemical data showed that Na+/K+-ATPase activity increased almost twofold after exposure of snail brains to the static magnetic field. Similarly, P-31 NMR data revealed a trend of increasing ATP consumption and increase in intracellular pH mediated by the Na+/H+ exchanger in snail brains exposed to the static magnetic field. Importantly, current clamp recordings from the Br neuron confirmed the increase in activity of the Na+/K+ pump after exposure to the static magnetic field, as the magnitude of ouabain's effect measured on the membrane resting potential, action potential, and interspike interval duration was higher in neurons exposed to the magnetic field. Metabolic pathways through which the magnetic field influenced the Na+/K+ pump could involve phosphorylation and dephosphorylation, as blocking these processes abolished the effect of the static magnetic field.
PB  - Springer, New York
T2  - Journal of Comparative Physiology A-Neuroethology Sensory Neural and Behavioral Physiology
T1  - Involvement of Na+/K(+)pump in fine modulation of bursting activity of the snail Br neuron by 10 mT static magnetic field
EP  - 540
IS  - 7
SP  - 525
VL  - 198
DO  - 10.1007/s00359-012-0727-0
ER  - 

@article{
author = "Nikolić, Ljiljana M. and Todorović, Nataša and Zakrzewska, Joanna and Stanić, Marina and Raus, Snežana Z and Kalauzi, Aleksandar and Janac, Branka B",
year = "2012",
abstract = "The spontaneously active Br neuron from the brain-subesophageal ganglion complex of the garden snail Helix pomatia rhythmically generates regular bursts of action potentials with quiescent intervals accompanied by slow oscillations of membrane potential. We examined the involvement of the Na+/K+ pump in modulating its bursting activity by applying a static magnetic field. Whole snail brains and Br neuron were exposed to the 10-mT static magnetic field for 15 min. Biochemical data showed that Na+/K+-ATPase activity increased almost twofold after exposure of snail brains to the static magnetic field. Similarly, P-31 NMR data revealed a trend of increasing ATP consumption and increase in intracellular pH mediated by the Na+/H+ exchanger in snail brains exposed to the static magnetic field. Importantly, current clamp recordings from the Br neuron confirmed the increase in activity of the Na+/K+ pump after exposure to the static magnetic field, as the magnitude of ouabain's effect measured on the membrane resting potential, action potential, and interspike interval duration was higher in neurons exposed to the magnetic field. Metabolic pathways through which the magnetic field influenced the Na+/K+ pump could involve phosphorylation and dephosphorylation, as blocking these processes abolished the effect of the static magnetic field.",
publisher = "Springer, New York",
journal = "Journal of Comparative Physiology A-Neuroethology Sensory Neural and Behavioral Physiology",
title = "Involvement of Na+/K(+)pump in fine modulation of bursting activity of the snail Br neuron by 10 mT static magnetic field",
pages = "540-525",
number = "7",
volume = "198",
doi = "10.1007/s00359-012-0727-0"
}

Nikolić, L. M., Todorović, N., Zakrzewska, J., Stanić, M., Raus, S. Z., Kalauzi, A.,& Janac, B. B.. (2012). Involvement of Na+/K(+)pump in fine modulation of bursting activity of the snail Br neuron by 10 mT static magnetic field. in Journal of Comparative Physiology A-Neuroethology Sensory Neural and Behavioral Physiology
Springer, New York., 198(7), 525-540.
https://doi.org/10.1007/s00359-012-0727-0

Nikolić LM, Todorović N, Zakrzewska J, Stanić M, Raus SZ, Kalauzi A, Janac BB. Involvement of Na+/K(+)pump in fine modulation of bursting activity of the snail Br neuron by 10 mT static magnetic field. in Journal of Comparative Physiology A-Neuroethology Sensory Neural and Behavioral Physiology. 2012;198(7):525-540.
doi:10.1007/s00359-012-0727-0 .

Nikolić, Ljiljana M., Todorović, Nataša, Zakrzewska, Joanna, Stanić, Marina, Raus, Snežana Z, Kalauzi, Aleksandar, Janac, Branka B, "Involvement of Na+/K(+)pump in fine modulation of bursting activity of the snail Br neuron by 10 mT static magnetic field" in Journal of Comparative Physiology A-Neuroethology Sensory Neural and Behavioral Physiology, 198, no. 7 (2012):525-540,
https://doi.org/10.1007/s00359-012-0727-0 . .

TY  - JOUR
AU  - Spasić, Slađana
AU  - Nikolić, Ljiljana M.
AU  - Mutavdžić, Dragosav
AU  - Šaponjić, Jasna
PY  - 2011
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/468
AB  - We applied a combination of fractal analysis and Independent Component Analysis (ICA) method to detect the sources of fractal complexity in snail Br neuron activity induced by static magnetic field of 2.7 mT. The fractal complexity of Br neuron activity was analyzed before (Control), during (MF), and after (AMF) exposure to the static magnetic field in six experimental animals. We estimated the fractal dimension (FD) of electrophysiological signals using Higuchi's algorithm, and empirical FD distributions. By using the Principal Component Analysis (PCA) and FastICA algorithm we determined the number of components, and defined the statistically independent components (ICs) in the fractal complexity of signal waveforms. We have isolated two independent components of the empirical FD distributions for each of three groups of data by using FastICA algorithm. ICs represent the sources of fractal waveforms complexity of Br neuron activity in particular experimental conditions. Our main results have shown that there could be two opposite intrinsic mechanisms in single snail Br neuron response to static magnetic field stimulation. We named identified ICs that correspond to those mechanisms - the component of plasticity and the component of elasticity. We have shown that combination of fractal analysis with ICA method could be very useful for the decomposition and identification of the sources of fractal complexity of bursting neuronal activity waveforms.
PB  - Elsevier Ireland Ltd, Clare
T2  - Computer Methods and Programs in Biomedicine
T1  - Independent complexity patterns in single neuron activity induced by static magnetic field
EP  - 218
IS  - 2
SP  - 212
VL  - 104
DO  - 10.1016/j.cmpb.2011.07.006
ER  - 

@article{
author = "Spasić, Slađana and Nikolić, Ljiljana M. and Mutavdžić, Dragosav and Šaponjić, Jasna",
year = "2011",
abstract = "We applied a combination of fractal analysis and Independent Component Analysis (ICA) method to detect the sources of fractal complexity in snail Br neuron activity induced by static magnetic field of 2.7 mT. The fractal complexity of Br neuron activity was analyzed before (Control), during (MF), and after (AMF) exposure to the static magnetic field in six experimental animals. We estimated the fractal dimension (FD) of electrophysiological signals using Higuchi's algorithm, and empirical FD distributions. By using the Principal Component Analysis (PCA) and FastICA algorithm we determined the number of components, and defined the statistically independent components (ICs) in the fractal complexity of signal waveforms. We have isolated two independent components of the empirical FD distributions for each of three groups of data by using FastICA algorithm. ICs represent the sources of fractal waveforms complexity of Br neuron activity in particular experimental conditions. Our main results have shown that there could be two opposite intrinsic mechanisms in single snail Br neuron response to static magnetic field stimulation. We named identified ICs that correspond to those mechanisms - the component of plasticity and the component of elasticity. We have shown that combination of fractal analysis with ICA method could be very useful for the decomposition and identification of the sources of fractal complexity of bursting neuronal activity waveforms.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Computer Methods and Programs in Biomedicine",
title = "Independent complexity patterns in single neuron activity induced by static magnetic field",
pages = "218-212",
number = "2",
volume = "104",
doi = "10.1016/j.cmpb.2011.07.006"
}

Spasić, S., Nikolić, L. M., Mutavdžić, D.,& Šaponjić, J.. (2011). Independent complexity patterns in single neuron activity induced by static magnetic field. in Computer Methods and Programs in Biomedicine
Elsevier Ireland Ltd, Clare., 104(2), 212-218.
https://doi.org/10.1016/j.cmpb.2011.07.006

Spasić S, Nikolić LM, Mutavdžić D, Šaponjić J. Independent complexity patterns in single neuron activity induced by static magnetic field. in Computer Methods and Programs in Biomedicine. 2011;104(2):212-218.
doi:10.1016/j.cmpb.2011.07.006 .

Spasić, Slađana, Nikolić, Ljiljana M., Mutavdžić, Dragosav, Šaponjić, Jasna, "Independent complexity patterns in single neuron activity induced by static magnetic field" in Computer Methods and Programs in Biomedicine, 104, no. 2 (2011):212-218,
https://doi.org/10.1016/j.cmpb.2011.07.006 . .

TY  - JOUR
AU  - Spasić, Slađana
AU  - Nikolić, Ljiljana M.
AU  - Mutavdžić, Dragosav
PY  - 2011
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/457
AB  - In the present work we report a new combination of fractal analysis and some advanced statistical methods and their application for the quantitative detection of the effects of a static magnetic field of 2.7 mT on fractal complexity changes of Br neuron activity in the subesophageal ganglia of the garden snail Helix pomatia. We used factor analysis (FA) in the analysis of the empirical distribution of fractal dimension (FD). FA showed that there are two factors in the empirical distribution of FD. Results indicated that the significant changes in the fractal complexity of Br neuron activity occurred during treatment with a magnetic field, were extended to the post exposure period.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - Effect of a static magnetic field on the fractal complexity of bursting activity of the br neuron in the snail detected by factor analysis
EP  - 183
IS  - 1
SP  - 177
VL  - 63
DO  - 10.2298/ABS1101177S
ER  - 

@article{
author = "Spasić, Slađana and Nikolić, Ljiljana M. and Mutavdžić, Dragosav",
year = "2011",
abstract = "In the present work we report a new combination of fractal analysis and some advanced statistical methods and their application for the quantitative detection of the effects of a static magnetic field of 2.7 mT on fractal complexity changes of Br neuron activity in the subesophageal ganglia of the garden snail Helix pomatia. We used factor analysis (FA) in the analysis of the empirical distribution of fractal dimension (FD). FA showed that there are two factors in the empirical distribution of FD. Results indicated that the significant changes in the fractal complexity of Br neuron activity occurred during treatment with a magnetic field, were extended to the post exposure period.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Effect of a static magnetic field on the fractal complexity of bursting activity of the br neuron in the snail detected by factor analysis",
pages = "183-177",
number = "1",
volume = "63",
doi = "10.2298/ABS1101177S"
}

Spasić, S., Nikolić, L. M.,& Mutavdžić, D.. (2011). Effect of a static magnetic field on the fractal complexity of bursting activity of the br neuron in the snail detected by factor analysis. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 63(1), 177-183.
https://doi.org/10.2298/ABS1101177S

Spasić S, Nikolić LM, Mutavdžić D. Effect of a static magnetic field on the fractal complexity of bursting activity of the br neuron in the snail detected by factor analysis. in Archives of Biological Sciences. 2011;63(1):177-183.
doi:10.2298/ABS1101177S .

Spasić, Slađana, Nikolić, Ljiljana M., Mutavdžić, Dragosav, "Effect of a static magnetic field on the fractal complexity of bursting activity of the br neuron in the snail detected by factor analysis" in Archives of Biological Sciences, 63, no. 1 (2011):177-183,
https://doi.org/10.2298/ABS1101177S . .