TY  - JOUR
AU  - Beara, Ivana N.
AU  - Lesjak, Marija M.
AU  - Cetojevic-Simin, Dragana D.
AU  - Marjanović, Žaklina
AU  - Ristic, Jelena D.
AU  - Mrkonjic, Zorica O.
AU  - Mimica-Dukic, Neda M.
PY  - 2014
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/780
AB  - The aim of this study was a comprehensive investigation on phenolic profile, antioxidant, anti-inflammatory and cytotoxic activity of the still insufficiently explored black summer truffles (Tuber aestivum Vittad.) and white (Tuber magnatum Pico) truffles. Methanol and water extracts, obtained by maceration and Soxhlet extraction, were examined. Forty-five phenolics was studied using LC-MS/MS: presence of 14 compounds was confirmed, with the most dominant being p-hydroxybenzoic acid, baicalein and kaempferol (T. aestivum), epicatechin and catechin (T. magnatum). Moderate antioxidant activity of both species was determined through several assays. Only T. magnatum showed anti-inflammatory potential by inhibiting COX-1 and 12-LOX pathway products synthesis. Methanol extracts exerted cytotoxicity against some tumour cell lines (HeLa, MCF7, HT-29), besides the prominent activity of water extracts towards breast adenocarcinoma (MCF7). To conclude, these results support further investigations of phytochemicals and biological activity towards verification of nutraceutical use of both species.
PB  - Elsevier Sci Ltd, Oxford
T2  - Food Chemistry
T1  - Phenolic profile, antioxidant, anti-inflammatory and cytotoxic activities of black (Tuber aestivum Vittad.) and white (Tuber magnatum Pico) truffles
EP  - 466
SP  - 460
VL  - 165
DO  - 10.1016/j.foodchem.2014.05.116
ER  - 

@article{
author = "Beara, Ivana N. and Lesjak, Marija M. and Cetojevic-Simin, Dragana D. and Marjanović, Žaklina and Ristic, Jelena D. and Mrkonjic, Zorica O. and Mimica-Dukic, Neda M.",
year = "2014",
abstract = "The aim of this study was a comprehensive investigation on phenolic profile, antioxidant, anti-inflammatory and cytotoxic activity of the still insufficiently explored black summer truffles (Tuber aestivum Vittad.) and white (Tuber magnatum Pico) truffles. Methanol and water extracts, obtained by maceration and Soxhlet extraction, were examined. Forty-five phenolics was studied using LC-MS/MS: presence of 14 compounds was confirmed, with the most dominant being p-hydroxybenzoic acid, baicalein and kaempferol (T. aestivum), epicatechin and catechin (T. magnatum). Moderate antioxidant activity of both species was determined through several assays. Only T. magnatum showed anti-inflammatory potential by inhibiting COX-1 and 12-LOX pathway products synthesis. Methanol extracts exerted cytotoxicity against some tumour cell lines (HeLa, MCF7, HT-29), besides the prominent activity of water extracts towards breast adenocarcinoma (MCF7). To conclude, these results support further investigations of phytochemicals and biological activity towards verification of nutraceutical use of both species.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Food Chemistry",
title = "Phenolic profile, antioxidant, anti-inflammatory and cytotoxic activities of black (Tuber aestivum Vittad.) and white (Tuber magnatum Pico) truffles",
pages = "466-460",
volume = "165",
doi = "10.1016/j.foodchem.2014.05.116"
}

Beara, I. N., Lesjak, M. M., Cetojevic-Simin, D. D., Marjanović, Ž., Ristic, J. D., Mrkonjic, Z. O.,& Mimica-Dukic, N. M.. (2014). Phenolic profile, antioxidant, anti-inflammatory and cytotoxic activities of black (Tuber aestivum Vittad.) and white (Tuber magnatum Pico) truffles. in Food Chemistry
Elsevier Sci Ltd, Oxford., 165, 460-466.
https://doi.org/10.1016/j.foodchem.2014.05.116

Beara IN, Lesjak MM, Cetojevic-Simin DD, Marjanović Ž, Ristic JD, Mrkonjic ZO, Mimica-Dukic NM. Phenolic profile, antioxidant, anti-inflammatory and cytotoxic activities of black (Tuber aestivum Vittad.) and white (Tuber magnatum Pico) truffles. in Food Chemistry. 2014;165:460-466.
doi:10.1016/j.foodchem.2014.05.116 .

Beara, Ivana N., Lesjak, Marija M., Cetojevic-Simin, Dragana D., Marjanović, Žaklina, Ristic, Jelena D., Mrkonjic, Zorica O., Mimica-Dukic, Neda M., "Phenolic profile, antioxidant, anti-inflammatory and cytotoxic activities of black (Tuber aestivum Vittad.) and white (Tuber magnatum Pico) truffles" in Food Chemistry, 165 (2014):460-466,
https://doi.org/10.1016/j.foodchem.2014.05.116 . .