TY  - JOUR
AU  - Tommonaro, Giuseppina
AU  - Pejin, Boris
AU  - Iodice, Carmine
AU  - Tafuto, Antonietta
AU  - De Rosa, Salvatore
PY  - 2016
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/995
AB  - The acetylcholinesterase inhibitory and/or antitumour activities of amino-, thio- and ester-derivatives of avarol selected were evaluated for the first time at in vitro conditions. Avarol-3',4'-dithioglycol (1) and avarol-4'-(3)mercaptopropionic acid (3) were shown to be the best inhibitors of the enzyme tested (0.50 mu g and IC50 0.05 mM and 0.50 mu g and IC50 0.12 mM, respectively), while 4'-tryptamine-avarone (9) and avarol-3'-(3)mercaptopropionic acid (2) exhibited the highest cytotoxicity against the human breast T-47D cancer cell line (IC50 0.66 mu g/mL and 1.25 mu g/mL, respectively). According to experimental data obtained, the sesquiterpenoid hydroquinone structure of bioactive avarol derivatives may inspire development of new pharmacologically useful substances to be used in the treatment of Alzheimer's disease and/or human breast tumour.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Enzyme Inhibition and Medicinal Chemistry
T1  - Further in vitro biological activity evaluation of amino-, thio- and ester-derivatives of avarol
EP  - 686
IS  - 4
SP  - 684
VL  - 31
DO  - 10.3109/14756366.2015.1057724
ER  - 

@article{
author = "Tommonaro, Giuseppina and Pejin, Boris and Iodice, Carmine and Tafuto, Antonietta and De Rosa, Salvatore",
year = "2016",
abstract = "The acetylcholinesterase inhibitory and/or antitumour activities of amino-, thio- and ester-derivatives of avarol selected were evaluated for the first time at in vitro conditions. Avarol-3',4'-dithioglycol (1) and avarol-4'-(3)mercaptopropionic acid (3) were shown to be the best inhibitors of the enzyme tested (0.50 mu g and IC50 0.05 mM and 0.50 mu g and IC50 0.12 mM, respectively), while 4'-tryptamine-avarone (9) and avarol-3'-(3)mercaptopropionic acid (2) exhibited the highest cytotoxicity against the human breast T-47D cancer cell line (IC50 0.66 mu g/mL and 1.25 mu g/mL, respectively). According to experimental data obtained, the sesquiterpenoid hydroquinone structure of bioactive avarol derivatives may inspire development of new pharmacologically useful substances to be used in the treatment of Alzheimer's disease and/or human breast tumour.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",
title = "Further in vitro biological activity evaluation of amino-, thio- and ester-derivatives of avarol",
pages = "686-684",
number = "4",
volume = "31",
doi = "10.3109/14756366.2015.1057724"
}

Tommonaro, G., Pejin, B., Iodice, C., Tafuto, A.,& De Rosa, S.. (2016). Further in vitro biological activity evaluation of amino-, thio- and ester-derivatives of avarol. in Journal of Enzyme Inhibition and Medicinal Chemistry
Taylor & Francis Ltd, Abingdon., 31(4), 684-686.
https://doi.org/10.3109/14756366.2015.1057724

Tommonaro G, Pejin B, Iodice C, Tafuto A, De Rosa S. Further in vitro biological activity evaluation of amino-, thio- and ester-derivatives of avarol. in Journal of Enzyme Inhibition and Medicinal Chemistry. 2016;31(4):684-686.
doi:10.3109/14756366.2015.1057724 .

Tommonaro, Giuseppina, Pejin, Boris, Iodice, Carmine, Tafuto, Antonietta, De Rosa, Salvatore, "Further in vitro biological activity evaluation of amino-, thio- and ester-derivatives of avarol" in Journal of Enzyme Inhibition and Medicinal Chemistry, 31, no. 4 (2016):684-686,
https://doi.org/10.3109/14756366.2015.1057724 . .

TY  - JOUR
AU  - Tommonaro, Giuseppina
AU  - Pejin, Boris
AU  - Iodice, Carmine
AU  - Tafuto, Antonietta
AU  - De Rosa, Salvatore
PY  - 2015
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/827
AB  - The acetylcholinesterase inhibitory and/or antitumour activities of amino-, thio-and ester-derivatives of avarol selected were evaluated for the first time at in vitro conditions. Avarol-3',4'-dithioglycol (1) and avarol-4'-(3) mercaptopropionic acid (3) were shown to be the best inhibitors of the enzyme tested (0.50 mu g and IC50 0.05mM and 0.50 mg and IC50 0.12 mM, respectively), while 4'-tryptamine-avarone (9) and avarol-3'-(3) mercaptopropionic acid (2) exhibited the highest cytotoxicity against the human breast T-47D cancer cell line (IC50 0.66 mu g/mL and 1.25 mu g/mL, respectively). According to experimental data obtained, the sesquiterpenoid hydroquinone structure of bioactive avarol derivatives may inspire development of new pharmacologically useful substances to be used in the treatment of Alzheimer's disease and/or human breast tumour.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Enzyme Inhibition and Medicinal Chemistry
T1  - Further in vitro biological activity evaluation of amino-, thio- and ester-derivatives of avarol
EP  - 335
IS  - 2
SP  - 333
VL  - 30
DO  - 10.3109/14756366.2014.913037
ER  - 

@article{
author = "Tommonaro, Giuseppina and Pejin, Boris and Iodice, Carmine and Tafuto, Antonietta and De Rosa, Salvatore",
year = "2015",
abstract = "The acetylcholinesterase inhibitory and/or antitumour activities of amino-, thio-and ester-derivatives of avarol selected were evaluated for the first time at in vitro conditions. Avarol-3',4'-dithioglycol (1) and avarol-4'-(3) mercaptopropionic acid (3) were shown to be the best inhibitors of the enzyme tested (0.50 mu g and IC50 0.05mM and 0.50 mg and IC50 0.12 mM, respectively), while 4'-tryptamine-avarone (9) and avarol-3'-(3) mercaptopropionic acid (2) exhibited the highest cytotoxicity against the human breast T-47D cancer cell line (IC50 0.66 mu g/mL and 1.25 mu g/mL, respectively). According to experimental data obtained, the sesquiterpenoid hydroquinone structure of bioactive avarol derivatives may inspire development of new pharmacologically useful substances to be used in the treatment of Alzheimer's disease and/or human breast tumour.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",
title = "Further in vitro biological activity evaluation of amino-, thio- and ester-derivatives of avarol",
pages = "335-333",
number = "2",
volume = "30",
doi = "10.3109/14756366.2014.913037"
}

Tommonaro, G., Pejin, B., Iodice, C., Tafuto, A.,& De Rosa, S.. (2015). Further in vitro biological activity evaluation of amino-, thio- and ester-derivatives of avarol. in Journal of Enzyme Inhibition and Medicinal Chemistry
Taylor & Francis Ltd, Abingdon., 30(2), 333-335.
https://doi.org/10.3109/14756366.2014.913037

Tommonaro G, Pejin B, Iodice C, Tafuto A, De Rosa S. Further in vitro biological activity evaluation of amino-, thio- and ester-derivatives of avarol. in Journal of Enzyme Inhibition and Medicinal Chemistry. 2015;30(2):333-335.
doi:10.3109/14756366.2014.913037 .

Tommonaro, Giuseppina, Pejin, Boris, Iodice, Carmine, Tafuto, Antonietta, De Rosa, Salvatore, "Further in vitro biological activity evaluation of amino-, thio- and ester-derivatives of avarol" in Journal of Enzyme Inhibition and Medicinal Chemistry, 30, no. 2 (2015):333-335,
https://doi.org/10.3109/14756366.2014.913037 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Iodice, Carmine
AU  - Tommonaro, Giuseppina
AU  - Stanimirović, Bojana
AU  - Ciric, Ana
AU  - Glamočlija, Jasmina
AU  - Nikolic, Milos
AU  - De Rosa, Salvatore
AU  - Soković, Marina
PY  - 2014
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/776
AB  - This work extends in vitro screening of antimicrobial activity of the sesquiterpene hydroquinone avarol, a main secondary metabolite of the Mediterranean sponge species Dysidea avara. The antimicrobial activity was in part evaluated by microdilution method against selected bacterial and fungal strains. Additionally, the screening included evaluation of anti-quorum sensing (anti-QS) effects. At a different extent avarol was proven to be active against all the microorganisms tested (MIC 0.002-0.008 mg/mL and MBC 0.004-0.016 mg/mL; MIC 0.004-0.015 mg/mL and MFC 0.008-0.030 mg/mL; respectively). This marine natural product also showed moderate anti-QS effects, reducing Pseudomonas aeruginosa PAO1 biofilm formation (75%), its twitching and protrusions motilities as well as pyocianin production (39%). According to the best of our knowledge, this is the first report both on avarol anti Gram-negative bacterial activity and anti-QS effects.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Current Pharmaceutical Biotechnology
T1  - Further in vitro Evaluation of Antimicrobial Activity of the Marine Sesquiterpene Hydroquinone Avarol
EP  - 588
IS  - 6
SP  - 583
VL  - 15
DO  - 10.2174/138920101506140910152253
ER  - 

@article{
author = "Pejin, Boris and Iodice, Carmine and Tommonaro, Giuseppina and Stanimirović, Bojana and Ciric, Ana and Glamočlija, Jasmina and Nikolic, Milos and De Rosa, Salvatore and Soković, Marina",
year = "2014",
abstract = "This work extends in vitro screening of antimicrobial activity of the sesquiterpene hydroquinone avarol, a main secondary metabolite of the Mediterranean sponge species Dysidea avara. The antimicrobial activity was in part evaluated by microdilution method against selected bacterial and fungal strains. Additionally, the screening included evaluation of anti-quorum sensing (anti-QS) effects. At a different extent avarol was proven to be active against all the microorganisms tested (MIC 0.002-0.008 mg/mL and MBC 0.004-0.016 mg/mL; MIC 0.004-0.015 mg/mL and MFC 0.008-0.030 mg/mL; respectively). This marine natural product also showed moderate anti-QS effects, reducing Pseudomonas aeruginosa PAO1 biofilm formation (75%), its twitching and protrusions motilities as well as pyocianin production (39%). According to the best of our knowledge, this is the first report both on avarol anti Gram-negative bacterial activity and anti-QS effects.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Current Pharmaceutical Biotechnology",
title = "Further in vitro Evaluation of Antimicrobial Activity of the Marine Sesquiterpene Hydroquinone Avarol",
pages = "588-583",
number = "6",
volume = "15",
doi = "10.2174/138920101506140910152253"
}

Pejin, B., Iodice, C., Tommonaro, G., Stanimirović, B., Ciric, A., Glamočlija, J., Nikolic, M., De Rosa, S.,& Soković, M.. (2014). Further in vitro Evaluation of Antimicrobial Activity of the Marine Sesquiterpene Hydroquinone Avarol. in Current Pharmaceutical Biotechnology
Bentham Science Publ Ltd, Sharjah., 15(6), 583-588.
https://doi.org/10.2174/138920101506140910152253

Pejin B, Iodice C, Tommonaro G, Stanimirović B, Ciric A, Glamočlija J, Nikolic M, De Rosa S, Soković M. Further in vitro Evaluation of Antimicrobial Activity of the Marine Sesquiterpene Hydroquinone Avarol. in Current Pharmaceutical Biotechnology. 2014;15(6):583-588.
doi:10.2174/138920101506140910152253 .

Pejin, Boris, Iodice, Carmine, Tommonaro, Giuseppina, Stanimirović, Bojana, Ciric, Ana, Glamočlija, Jasmina, Nikolic, Milos, De Rosa, Salvatore, Soković, Marina, "Further in vitro Evaluation of Antimicrobial Activity of the Marine Sesquiterpene Hydroquinone Avarol" in Current Pharmaceutical Biotechnology, 15, no. 6 (2014):583-588,
https://doi.org/10.2174/138920101506140910152253 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Iodice, Carmine
AU  - Tommonaro, Giuseppina
AU  - Bogdanović, Gordana
AU  - Kojić, Vesna 
AU  - De Rosa, Salvatore
PY  - 2014
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/779
AB  - The cytotoxicity of 4-leucine-avarone, amino derivative of the sponge Dysidea avara secondary metabolite avarone, was evaluated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide assay in vitro against seven human solid tumours for the first time. The compound tested induced dose-dependent cytotoxic response in all cancer cells showing better activity towards the lung A-549 and colon HT-29 cell lines (IC50 7.40M and 9.62M, respectively) than towards the breast adenocarcinoma ER positive MCF-7 and ER negative MDA-MB-231 cells (IC50 11.64M and 17.31M, respectively), the prostate adenocarcinoma PC-3 and epiteloid cervix carcinoma HeLa cells (IC50 14.24M and 15.54M, respectively). No toxicity was found towards the foetal lung fibroblast MRC-5 cell line at the concentrations used. According to experimental data obtained, the sesquiterpenoid quinone structure of avarone may inspire development of new drug-like substances with improved cytotoxicity on lung cancer in humans.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Further in vitro evaluation of cytotoxicity of the marine natural product derivative 4 '-leucine-avarone
EP  - 350
IS  - 5
SP  - 347
VL  - 28
DO  - 10.1080/14786419.2013.863201
ER  - 

@article{
author = "Pejin, Boris and Iodice, Carmine and Tommonaro, Giuseppina and Bogdanović, Gordana and Kojić, Vesna  and De Rosa, Salvatore",
year = "2014",
abstract = "The cytotoxicity of 4-leucine-avarone, amino derivative of the sponge Dysidea avara secondary metabolite avarone, was evaluated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide assay in vitro against seven human solid tumours for the first time. The compound tested induced dose-dependent cytotoxic response in all cancer cells showing better activity towards the lung A-549 and colon HT-29 cell lines (IC50 7.40M and 9.62M, respectively) than towards the breast adenocarcinoma ER positive MCF-7 and ER negative MDA-MB-231 cells (IC50 11.64M and 17.31M, respectively), the prostate adenocarcinoma PC-3 and epiteloid cervix carcinoma HeLa cells (IC50 14.24M and 15.54M, respectively). No toxicity was found towards the foetal lung fibroblast MRC-5 cell line at the concentrations used. According to experimental data obtained, the sesquiterpenoid quinone structure of avarone may inspire development of new drug-like substances with improved cytotoxicity on lung cancer in humans.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Further in vitro evaluation of cytotoxicity of the marine natural product derivative 4 '-leucine-avarone",
pages = "350-347",
number = "5",
volume = "28",
doi = "10.1080/14786419.2013.863201"
}

Pejin, B., Iodice, C., Tommonaro, G., Bogdanović, G., Kojić, V.,& De Rosa, S.. (2014). Further in vitro evaluation of cytotoxicity of the marine natural product derivative 4 '-leucine-avarone. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 28(5), 347-350.
https://doi.org/10.1080/14786419.2013.863201

Pejin B, Iodice C, Tommonaro G, Bogdanović G, Kojić V, De Rosa S. Further in vitro evaluation of cytotoxicity of the marine natural product derivative 4 '-leucine-avarone. in Natural Product Research. 2014;28(5):347-350.
doi:10.1080/14786419.2013.863201 .

Pejin, Boris, Iodice, Carmine, Tommonaro, Giuseppina, Bogdanović, Gordana, Kojić, Vesna , De Rosa, Salvatore, "Further in vitro evaluation of cytotoxicity of the marine natural product derivative 4 '-leucine-avarone" in Natural Product Research, 28, no. 5 (2014):347-350,
https://doi.org/10.1080/14786419.2013.863201 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Tommonaro, Giuseppina
AU  - Iodice, Carmine
AU  - Tešević, Vele
AU  - Vajs, Vlatka E
AU  - De Rosa, Salvatore
PY  - 2013
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/660
AB  - The phytochemical investigation conducted on a foliose lichen, Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), led to the isolation of a new depsidone in the form of its diacetate derivative which showed a moderate acetylcholinesterase inhibition activity (1 mu g) in vitro. This is the first record of identified depsidone structure in searching for these inhibitors.
PB  - Informa Healthcare, London
T2  - Journal of Enzyme Inhibition and Medicinal Chemistry
T1  - A new depsidone of Lobaria pulmonaria with acetylcholinesterase inhibition activity
EP  - 878
IS  - 4
SP  - 876
VL  - 28
DO  - 10.3109/14756366.2012.677839
ER  - 

@article{
author = "Pejin, Boris and Tommonaro, Giuseppina and Iodice, Carmine and Tešević, Vele and Vajs, Vlatka E and De Rosa, Salvatore",
year = "2013",
abstract = "The phytochemical investigation conducted on a foliose lichen, Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), led to the isolation of a new depsidone in the form of its diacetate derivative which showed a moderate acetylcholinesterase inhibition activity (1 mu g) in vitro. This is the first record of identified depsidone structure in searching for these inhibitors.",
publisher = "Informa Healthcare, London",
journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",
title = "A new depsidone of Lobaria pulmonaria with acetylcholinesterase inhibition activity",
pages = "878-876",
number = "4",
volume = "28",
doi = "10.3109/14756366.2012.677839"
}

Pejin, B., Tommonaro, G., Iodice, C., Tešević, V., Vajs, V. E.,& De Rosa, S.. (2013). A new depsidone of Lobaria pulmonaria with acetylcholinesterase inhibition activity. in Journal of Enzyme Inhibition and Medicinal Chemistry
Informa Healthcare, London., 28(4), 876-878.
https://doi.org/10.3109/14756366.2012.677839

Pejin B, Tommonaro G, Iodice C, Tešević V, Vajs VE, De Rosa S. A new depsidone of Lobaria pulmonaria with acetylcholinesterase inhibition activity. in Journal of Enzyme Inhibition and Medicinal Chemistry. 2013;28(4):876-878.
doi:10.3109/14756366.2012.677839 .

Pejin, Boris, Tommonaro, Giuseppina, Iodice, Carmine, Tešević, Vele, Vajs, Vlatka E, De Rosa, Salvatore, "A new depsidone of Lobaria pulmonaria with acetylcholinesterase inhibition activity" in Journal of Enzyme Inhibition and Medicinal Chemistry, 28, no. 4 (2013):876-878,
https://doi.org/10.3109/14756366.2012.677839 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Iodice, Carmine
AU  - Tommonaro, Giuseppina
AU  - Sabovljević, Marko S
AU  - Bianco, Armandodoriano
AU  - Tešević, Vele
AU  - Vajs, Vlatka E
AU  - De Rosa, Salvatore
PY  - 2012
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/577
AB  - Although the second biggest terrestrial group of plants, bryophytes remain poorly known chemically compared to the angiosperms. In this article, the sugars of the moss Rhodobryum ontariense, an unstudied representative of the medicinally known genus, are reported. The chemical analysis revealed the usual plant sugar sucrose, and a new sugar, fructooligosaccharide 1-kestose, which is reported first not only for the genus Rhodobryum, but also for mosses. The trisaccharides have been scantily reported in bryophytes hitherto. This gives more significance to this study for further investigation of its role in the moss species. The health-promoting effect of 1-kestose is also briefly discussed.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Sugar composition of the moss Rhodobryum ontariense (Kindb.) Kindb.
EP  - 215
IS  - 3
SP  - 209
VL  - 26
DO  - 10.1080/14786419.2010.535163
ER  - 

@article{
author = "Pejin, Boris and Iodice, Carmine and Tommonaro, Giuseppina and Sabovljević, Marko S and Bianco, Armandodoriano and Tešević, Vele and Vajs, Vlatka E and De Rosa, Salvatore",
year = "2012",
abstract = "Although the second biggest terrestrial group of plants, bryophytes remain poorly known chemically compared to the angiosperms. In this article, the sugars of the moss Rhodobryum ontariense, an unstudied representative of the medicinally known genus, are reported. The chemical analysis revealed the usual plant sugar sucrose, and a new sugar, fructooligosaccharide 1-kestose, which is reported first not only for the genus Rhodobryum, but also for mosses. The trisaccharides have been scantily reported in bryophytes hitherto. This gives more significance to this study for further investigation of its role in the moss species. The health-promoting effect of 1-kestose is also briefly discussed.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Sugar composition of the moss Rhodobryum ontariense (Kindb.) Kindb.",
pages = "215-209",
number = "3",
volume = "26",
doi = "10.1080/14786419.2010.535163"
}

Pejin, B., Iodice, C., Tommonaro, G., Sabovljević, M. S., Bianco, A., Tešević, V., Vajs, V. E.,& De Rosa, S.. (2012). Sugar composition of the moss Rhodobryum ontariense (Kindb.) Kindb.. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 26(3), 209-215.
https://doi.org/10.1080/14786419.2010.535163

Pejin B, Iodice C, Tommonaro G, Sabovljević MS, Bianco A, Tešević V, Vajs VE, De Rosa S. Sugar composition of the moss Rhodobryum ontariense (Kindb.) Kindb.. in Natural Product Research. 2012;26(3):209-215.
doi:10.1080/14786419.2010.535163 .

Pejin, Boris, Iodice, Carmine, Tommonaro, Giuseppina, Sabovljević, Marko S, Bianco, Armandodoriano, Tešević, Vele, Vajs, Vlatka E, De Rosa, Salvatore, "Sugar composition of the moss Rhodobryum ontariense (Kindb.) Kindb." in Natural Product Research, 26, no. 3 (2012):209-215,
https://doi.org/10.1080/14786419.2010.535163 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Bianco, Armandodoriano
AU  - Newmaster, S
AU  - Sabovljević, Marko S
AU  - Vujisic, Ljubodrag V
AU  - Tešević, Vele
AU  - Vajs, Vlatka E
AU  - De Rosa, Salvatore
PY  - 2012
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/511
AB  - The chemical composition of Rhodobryum ontariense (Kindb.) Kindb. has not been previously investigated. Fatty acids of this moss were analysed qualitatively and quantitatively with an aim to identify its corresponding pattern. A total of eight fatty acids were identified including two acetylenic ones: 9,12,15-octadecatrien-6-ynoic acid (42.26%), alpha-linolenic acid (20.32%), palmitic acid (14.31%), 9,12-octadecadienoic-6-ynoic acid (13.31%), linoleic acid (5.25%), oleic acid (2.47%), stearic acid (1.14%) and gamma-linolenic acid (0.92%). To our knowledge, this is the first record of acetylenic fatty acids in the genus Rhodobryum. In general, acetylenic fatty acids vary considerably among different moss groups and have been used as a chemotaxonomic character in bryophyte classifications. Other species of Rhodobryum from Asia have been traditionally used in ethno medicine by indigenous cultures. Two fatty acids of those reported here, 9,12,15-octadecatrien-6-ynoic and alpha-linolenic acid, have known cardio protective activity, which supports respective claims of traditional herbal use of these mosses.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Fatty acids of Rhodobryum ontariense (Bryaceae)
EP  - 702
IS  - 8
SP  - 696
VL  - 26
DO  - 10.1080/14786419.2010.550580
ER  - 

@article{
author = "Pejin, Boris and Bianco, Armandodoriano and Newmaster, S and Sabovljević, Marko S and Vujisic, Ljubodrag V and Tešević, Vele and Vajs, Vlatka E and De Rosa, Salvatore",
year = "2012",
abstract = "The chemical composition of Rhodobryum ontariense (Kindb.) Kindb. has not been previously investigated. Fatty acids of this moss were analysed qualitatively and quantitatively with an aim to identify its corresponding pattern. A total of eight fatty acids were identified including two acetylenic ones: 9,12,15-octadecatrien-6-ynoic acid (42.26%), alpha-linolenic acid (20.32%), palmitic acid (14.31%), 9,12-octadecadienoic-6-ynoic acid (13.31%), linoleic acid (5.25%), oleic acid (2.47%), stearic acid (1.14%) and gamma-linolenic acid (0.92%). To our knowledge, this is the first record of acetylenic fatty acids in the genus Rhodobryum. In general, acetylenic fatty acids vary considerably among different moss groups and have been used as a chemotaxonomic character in bryophyte classifications. Other species of Rhodobryum from Asia have been traditionally used in ethno medicine by indigenous cultures. Two fatty acids of those reported here, 9,12,15-octadecatrien-6-ynoic and alpha-linolenic acid, have known cardio protective activity, which supports respective claims of traditional herbal use of these mosses.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Fatty acids of Rhodobryum ontariense (Bryaceae)",
pages = "702-696",
number = "8",
volume = "26",
doi = "10.1080/14786419.2010.550580"
}

Pejin, B., Bianco, A., Newmaster, S., Sabovljević, M. S., Vujisic, L. V., Tešević, V., Vajs, V. E.,& De Rosa, S.. (2012). Fatty acids of Rhodobryum ontariense (Bryaceae). in Natural Product Research
Taylor & Francis Ltd, Abingdon., 26(8), 696-702.
https://doi.org/10.1080/14786419.2010.550580

Pejin B, Bianco A, Newmaster S, Sabovljević MS, Vujisic LV, Tešević V, Vajs VE, De Rosa S. Fatty acids of Rhodobryum ontariense (Bryaceae). in Natural Product Research. 2012;26(8):696-702.
doi:10.1080/14786419.2010.550580 .

Pejin, Boris, Bianco, Armandodoriano, Newmaster, S, Sabovljević, Marko S, Vujisic, Ljubodrag V, Tešević, Vele, Vajs, Vlatka E, De Rosa, Salvatore, "Fatty acids of Rhodobryum ontariense (Bryaceae)" in Natural Product Research, 26, no. 8 (2012):696-702,
https://doi.org/10.1080/14786419.2010.550580 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Iodice, Carmine
AU  - Tommonaro, Giuseppina
AU  - De Rosa, Salvatore
PY  - 2008
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/281
AB  - Eleven new thio-avarol derivatives (3-13) were synthesized. Their antimicrobial, brine shrimp lethality, and free-radical scavenging activities and acetylcholinesterase inhibition, together with 12 already reported semisynthetic thioavarol derivatives (14-25), were evaluated. Structure-activity relationships among these thio derivatives were determined.
PB  - Amer Chemical Soc, Washington
T2  - Journal of Natural Products
T1  - Synthesis and Biological Activities of Thio-avarol Derivatives
EP  - 1853
IS  - 11
SP  - 1850
VL  - 71
DO  - 10.1021/np800318m
ER  - 

@article{
author = "Pejin, Boris and Iodice, Carmine and Tommonaro, Giuseppina and De Rosa, Salvatore",
year = "2008",
abstract = "Eleven new thio-avarol derivatives (3-13) were synthesized. Their antimicrobial, brine shrimp lethality, and free-radical scavenging activities and acetylcholinesterase inhibition, together with 12 already reported semisynthetic thioavarol derivatives (14-25), were evaluated. Structure-activity relationships among these thio derivatives were determined.",
publisher = "Amer Chemical Soc, Washington",
journal = "Journal of Natural Products",
title = "Synthesis and Biological Activities of Thio-avarol Derivatives",
pages = "1853-1850",
number = "11",
volume = "71",
doi = "10.1021/np800318m"
}

Pejin, B., Iodice, C., Tommonaro, G.,& De Rosa, S.. (2008). Synthesis and Biological Activities of Thio-avarol Derivatives. in Journal of Natural Products
Amer Chemical Soc, Washington., 71(11), 1850-1853.
https://doi.org/10.1021/np800318m

Pejin B, Iodice C, Tommonaro G, De Rosa S. Synthesis and Biological Activities of Thio-avarol Derivatives. in Journal of Natural Products. 2008;71(11):1850-1853.
doi:10.1021/np800318m .

Pejin, Boris, Iodice, Carmine, Tommonaro, Giuseppina, De Rosa, Salvatore, "Synthesis and Biological Activities of Thio-avarol Derivatives" in Journal of Natural Products, 71, no. 11 (2008):1850-1853,
https://doi.org/10.1021/np800318m . .