TY  - JOUR
AU  - Anicic, Neda
AU  - Gasic, Uros
AU  - Lu, Feng
AU  - Ciric, Ana
AU  - Ivanov, Marija
AU  - Jevtic, Bojan
AU  - Dimitrijević, Milena
AU  - Anđelković, Boban
AU  - Skoric, Marijana
AU  - Nestorović-Živković, Jasmina M
AU  - Mao, Yingle
AU  - Liu, Jia
AU  - Tang, Chunping
AU  - Soković, Marina
AU  - Ye, Yang
AU  - Misic, Danijela
PY  - 2021
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1485
AB  - Two Balkan Peninsula endemics, Nepeta rtanjensis and N. argolica subsp. argolica, both characterized by specialized metabolite profiles predominated by iridoids and phenolics, are differentiated according to the stereochemistry of major iridoid aglycone nepetalactone (NL). For the first time, the present study provides a comparative analysis of antimicrobial and immunomodulating activities of the two Nepeta species and their major iridoids isolated from natural sources-cis,trans-NL, trans,cis-NL, and 1,5,9-epideoxyloganic acid (1,5,9-eDLA), as well as of phenolic acid rosmarinic acid (RA). Methanol extracts and pure iridoids displayed excellent antimicrobial activity against eight strains of bacteria and seven strains of fungi. They were especially potent against food-borne pathogens such as L. monocytogenes, E. coli, S. aureus, Penicillium sp., and Aspergillus sp. Targeted iridoids were efficient agents in preventing biofilm formation of resistant P. aeruginosa strain, and they displayed additive antimicrobial interaction. Iridoids are, to a great extent, responsible for the prominent antimicrobial activities of the two Nepeta species, although are probably minor contributors to the moderate immunomodulatory effects. The analyzed iridoids and RA, individually or in mixtures, have the potential to be used in the pharmaceutical industry as potent antimicrobials, and in the food industry to increase the shelf life and safety of food products.
PB  - MDPI, Basel
T2  - Pharmaceuticals
T1  - Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources
IS  - 5
VL  - 14
DO  - 10.3390/ph14050414
ER  - 

@article{
author = "Anicic, Neda and Gasic, Uros and Lu, Feng and Ciric, Ana and Ivanov, Marija and Jevtic, Bojan and Dimitrijević, Milena and Anđelković, Boban and Skoric, Marijana and Nestorović-Živković, Jasmina M and Mao, Yingle and Liu, Jia and Tang, Chunping and Soković, Marina and Ye, Yang and Misic, Danijela",
year = "2021",
abstract = "Two Balkan Peninsula endemics, Nepeta rtanjensis and N. argolica subsp. argolica, both characterized by specialized metabolite profiles predominated by iridoids and phenolics, are differentiated according to the stereochemistry of major iridoid aglycone nepetalactone (NL). For the first time, the present study provides a comparative analysis of antimicrobial and immunomodulating activities of the two Nepeta species and their major iridoids isolated from natural sources-cis,trans-NL, trans,cis-NL, and 1,5,9-epideoxyloganic acid (1,5,9-eDLA), as well as of phenolic acid rosmarinic acid (RA). Methanol extracts and pure iridoids displayed excellent antimicrobial activity against eight strains of bacteria and seven strains of fungi. They were especially potent against food-borne pathogens such as L. monocytogenes, E. coli, S. aureus, Penicillium sp., and Aspergillus sp. Targeted iridoids were efficient agents in preventing biofilm formation of resistant P. aeruginosa strain, and they displayed additive antimicrobial interaction. Iridoids are, to a great extent, responsible for the prominent antimicrobial activities of the two Nepeta species, although are probably minor contributors to the moderate immunomodulatory effects. The analyzed iridoids and RA, individually or in mixtures, have the potential to be used in the pharmaceutical industry as potent antimicrobials, and in the food industry to increase the shelf life and safety of food products.",
publisher = "MDPI, Basel",
journal = "Pharmaceuticals",
title = "Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources",
number = "5",
volume = "14",
doi = "10.3390/ph14050414"
}

Anicic, N., Gasic, U., Lu, F., Ciric, A., Ivanov, M., Jevtic, B., Dimitrijević, M., Anđelković, B., Skoric, M., Nestorović-Živković, J. M., Mao, Y., Liu, J., Tang, C., Soković, M., Ye, Y.,& Misic, D.. (2021). Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources. in Pharmaceuticals
MDPI, Basel., 14(5).
https://doi.org/10.3390/ph14050414

Anicic N, Gasic U, Lu F, Ciric A, Ivanov M, Jevtic B, Dimitrijević M, Anđelković B, Skoric M, Nestorović-Živković JM, Mao Y, Liu J, Tang C, Soković M, Ye Y, Misic D. Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources. in Pharmaceuticals. 2021;14(5).
doi:10.3390/ph14050414 .

Anicic, Neda, Gasic, Uros, Lu, Feng, Ciric, Ana, Ivanov, Marija, Jevtic, Bojan, Dimitrijević, Milena, Anđelković, Boban, Skoric, Marijana, Nestorović-Živković, Jasmina M, Mao, Yingle, Liu, Jia, Tang, Chunping, Soković, Marina, Ye, Yang, Misic, Danijela, "Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources" in Pharmaceuticals, 14, no. 5 (2021),
https://doi.org/10.3390/ph14050414 . .