TY  - JOUR
AU  - Todorović, Tamara
AU  - Vukašinović, Jelena
AU  - Portalone, Gustavo
AU  - suleiman, sherif
AU  - Gligorijević, Nevenka
AU  - Bjelogrlic, Snezana K.
AU  - Jovanovic, Katarina
AU  - Radulović, Sinisa S
AU  - Andjelkovic, Katarina
AU  - Cassar, Analisse
AU  - Filipović, Nenad
AU  - Schembri-WIsmayer, Pierre
PY  - 2017
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/2027
AB  - Cobaltcomplexeswithsemi-andthiosemicarbazonesof8-quinolinecarboxaldehydehavebeensynthesizedandcharacterizedbyX-raydiffractionanalysis.Thesenovelcomplexesandapreviouslysynthesized cobaltcomplexwithaselenium-basedselenosemicarbazoneligandshowedmyeloiddifferentiationactivity onalltransretinoicacidresistantHL-60acutemyeloidleukaemiacells.Theyalsoshowedvaryinglevelsof cytotoxicityonfivehumantumorcelllines:cervixcarcinomacells(HeLa),lungadenocarcinomacells (A549),colorectaladenocarcinomacells(LS-174),breastcarcinomacells(MDA-MB-361),andchronicmyeloidleukaemia(K562)aswellasonenormalhumancellline:fetallungfibroblastcells(MRC-5).Leukaemia differentiationwasmoststronglyinducedbyametal-freeoxygenligandandtheseleniumligand,whilst thelatterandthecobaltIJII)complexwithanoxygenligandshowedthestrongestdose-dependentcytotoxic activity.Infouroutoffiveinvestigatedtumorcelllines,itwasofthesameorderofmagnitudeascisplatin. Thesebestcompounds,however,hadlowertoxicityonnon-transformedMRC-5cellsthancisplatin.
PB  - RSC Publishing
T2  - MedChemComm
T1  - (Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines
EP  - 111
IS  - 1
SP  - 103
VL  - 8
DO  - https://doi.org/10.1039/c6md00501b
ER  - 

@article{
author = "Todorović, Tamara and Vukašinović, Jelena and Portalone, Gustavo and suleiman, sherif and Gligorijević, Nevenka and Bjelogrlic, Snezana K. and Jovanovic, Katarina and Radulović, Sinisa S and Andjelkovic, Katarina and Cassar, Analisse and Filipović, Nenad and Schembri-WIsmayer, Pierre",
year = "2017",
abstract = "Cobaltcomplexeswithsemi-andthiosemicarbazonesof8-quinolinecarboxaldehydehavebeensynthesizedandcharacterizedbyX-raydiffractionanalysis.Thesenovelcomplexesandapreviouslysynthesized cobaltcomplexwithaselenium-basedselenosemicarbazoneligandshowedmyeloiddifferentiationactivity onalltransretinoicacidresistantHL-60acutemyeloidleukaemiacells.Theyalsoshowedvaryinglevelsof cytotoxicityonfivehumantumorcelllines:cervixcarcinomacells(HeLa),lungadenocarcinomacells (A549),colorectaladenocarcinomacells(LS-174),breastcarcinomacells(MDA-MB-361),andchronicmyeloidleukaemia(K562)aswellasonenormalhumancellline:fetallungfibroblastcells(MRC-5).Leukaemia differentiationwasmoststronglyinducedbyametal-freeoxygenligandandtheseleniumligand,whilst thelatterandthecobaltIJII)complexwithanoxygenligandshowedthestrongestdose-dependentcytotoxic activity.Infouroutoffiveinvestigatedtumorcelllines,itwasofthesameorderofmagnitudeascisplatin. Thesebestcompounds,however,hadlowertoxicityonnon-transformedMRC-5cellsthancisplatin.",
publisher = "RSC Publishing",
journal = "MedChemComm",
title = "(Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines",
pages = "111-103",
number = "1",
volume = "8",
doi = "https://doi.org/10.1039/c6md00501b"
}

Todorović, T., Vukašinović, J., Portalone, G., suleiman, s., Gligorijević, N., Bjelogrlic, S. K., Jovanovic, K., Radulović, S. S., Andjelkovic, K., Cassar, A., Filipović, N.,& Schembri-WIsmayer, P.. (2017). (Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines. in MedChemComm
RSC Publishing., 8(1), 103-111.
https://doi.org/https://doi.org/10.1039/c6md00501b

Todorović T, Vukašinović J, Portalone G, suleiman S, Gligorijević N, Bjelogrlic SK, Jovanovic K, Radulović SS, Andjelkovic K, Cassar A, Filipović N, Schembri-WIsmayer P. (Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines. in MedChemComm. 2017;8(1):103-111.
doi:https://doi.org/10.1039/c6md00501b .

Todorović, Tamara, Vukašinović, Jelena, Portalone, Gustavo, suleiman, sherif, Gligorijević, Nevenka, Bjelogrlic, Snezana K., Jovanovic, Katarina, Radulović, Sinisa S, Andjelkovic, Katarina, Cassar, Analisse, Filipović, Nenad, Schembri-WIsmayer, Pierre, "(Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines" in MedChemComm, 8, no. 1 (2017):103-111,
https://doi.org/https://doi.org/10.1039/c6md00501b . .